Ponazuril (Ref: Bay Vi 9143)
Last updated: 26/04/2021
(Also known as: Toltrazuril sulfone)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A medicinal drug, which is an active metabolite of toltrazuril, used to treat protozoal myeloencephalitis (EPM) in horses, caused by Sarcocystis neurona and coccidia in small mammals.
Current
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Horses; Cats; Dogs; Piglets; Cattle; Goats; Llamas
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C₁₈H₁₄F₃N₃O₆S
CC1=C(C=CC(=C1)N2C(=O)NC(=O)N(C2=O)C)OC3=CC=C(C=C3)S(=O)(=O)C(F)(F)F
No data
VBUNOIXRZNJNAD-UHFFFAOYSA-N
InChI=1S/C18H14F3N3O6S/c1-10-9-11(24-16(26)22-15(25)23(2)17(24)27)3-8-14(10)30-12-4-6-13(7-5-12)31(28,29)18(19,20)21/h3-9H,1-2H3,(H,22,25,26)
Yes
Coccidiostat, Antiparasitic, Antiprotozoal
Triazinetrione
>95%
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Synthetic
Acts by inhibiting mitochondrial respirayion and nuclear pyrimidine synthesis in the parasite
[Mitochondrial respiration, Inhibitor]
69004-04-2
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QP51AJ04
Antiprotozoals: Triazines
No
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457.38
1-methyl-3-(3-methyl-4-(4-(trifluoromethylsulfonyl)phenoxy)phenyl)-1,3,5-triazinane-2,4,6-trione
1-methyl-3-(3-methyl-4-(4-(trifluoromethylsulfonyl)phenoxy)phenyl)-1,3,5-triazinane-2,4,6-trione
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Off-white coloured powder
Marquis
Bayer Corporation
No UK national authorisation
Not applicable
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93.3
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500
Very persistent
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General literature cites the subtsance as being highly persistent with a DT₅₀ of > 1 year
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
980
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
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980
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Rat
Moderate
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Eliminated via the faeces
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
No data found
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause gastro-intestinal disturbance including vomiting and diarrhoea
Not explosive Incompatible with oxidising agents Will emit toxic gases when heated to decomposition including hydrocyanic acid and hydrogen fluoride
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NL (Not listed)
None allocated
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ponazuril
ponazuril
Ponazuril
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Ponazurilo
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242