Sucralfate
Last updated: 26/04/2021
(Also known as: sulfated disaccharide, aluminium salt)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
Used for the prevention and treatment of ulcers in the mouth, esophagous, stomach, and intestines
Current
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Cats; Dogs
Isomeric
C₁₂H₅₄Al₁₆O₇₅S₈
C(C1C(C(C(C(O1)OC2(C(C(C(O2)OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O
C([C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@]2([C@H]([C@@H]([C@H](O2)OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])COS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al])OS(=O)(=O)O[Al].O.O.O.O.O.O.O.O.O.O.O.O.O.O.O.O
MNQYNQBOVCBZIQ-JQOFMKNESA-A
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Yes
Medicinal drug: anti-ulcer
Disaccharides
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Synthetic
Acts as a stomach acid buffer
[Pepsin, Inhibitor], [Fibroblast growth factor 2, Agonist], [Pro-epidermal growth factor, Inducer], [Fibrinogen alpha chain, Antagonist], [Fibrinogen beta chain, Antagonist], [Fibrinogen gamma chain, Antagonist]
54182-58-0
259-018-4
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QA02BX02
Drugs for peptic ulcers and gastro-oesophageal reflux disease
No
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974.74
hexadeca-µ-hydroxytetracosahydroxy(µ8-91,3,4,6-tetra-O-sulfo-β-Dfructofuranosyl-a-D-glucopyranoside tetrakis(hydrogen sulfato)8-)))hexadecaaluminum
hexadeca-µ-hydroxytetracosahydroxy(µ8-91,3,4,6-tetra-O-sulfo-β-Dfructofuranosyl-a-D-glucopyranoside tetrakis(hydrogen sulfato)8-)))hexadecaaluminum
aluminium sucrose octasulphate
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White to yellow coloured amorphous powder
Antepsin
Idis pharma
No approved directly for animals - used under the 'prescribing cascade'
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Carafate
Generic product - multiple producers
No approved directly for animals - used under the 'prescribing cascade'
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
V3 Rat 12000
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Low
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HUMAN HEALTH AND PROTECTION
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V3 Rat 12000
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Low
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Intraperitoneal LD₅₀ > 4000 mg kg⁻¹
Rat
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Subcutaneous LD₅₀ > 12000 mg kg⁻¹
Rat
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Excreted mainly unchanged in the faeces in 24 hours
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
XNo, known not to cause a problem
No data found
 
May cause consipation Possible kidney toxicant
No information available
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NL (Not listed)
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sucralfate
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sucralfato
sucralfato
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Record last updated:
26/04/2021
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242