Yohimbine
Last updated: 21/06/2023
(Also known as: quebrachin)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A veterinary drug extracted from the evergreen Yohimbe tree (Pausinystalia johimbe ) used to reverse sedation in some mammals
Current
1896, first extracted
Dogs; Deer; Elk; Elephants
Isomeric
C₂₁H₂₆N₂O₃
COC(=O)C1C(CCC2C1CC3C4=C(CCN3C2)C5=CC=CC=C5N4)O
COC(=O)[C@H]1[C@H](CC[C@@H]2[C@@H]1C[C@H]3C4=C(CCN3C2)C5=CC=CC=C5N4)O
BLGXFZZNTVWLAY-SCYLSFHTSA-N
InChI=1S/C21H26N2O3/c1-26-21(25)19-15-10-17-20-14(13-4-2-3-5-16(13)22-20)8-9-23(17)11-12(15)6-7-18(19)24/h2-5,12,15,17-19,22,24H,6-11H2,1H3/t12-,15-,17-,18-,19+/m0/s1
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
yohimbine
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Plant derived substance: Indole alkaloid
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Natural
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[Alpha-2C adrenergic receptor, Agonist]
146-48-5
205-672-0
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QV03AB93
Therapeutic products: Antidoes
No
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354.44
17α-hydroxy-yohimban-16α-carboxylic acid methyl ester
methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylate
17-hydroxyyohimban-16-carboxylic acid methyl ester
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Solid
Yobine
Akorn Animal Health
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241
Moderate
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241
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5.37 X 1002
Calculated
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2.73
Moderate
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Soil adsorption and mobility
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None
Terrestrial ecotoxicology
43
Mouse
High
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HUMAN HEALTH AND PROTECTION
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43
Mouse
High
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Intraperitoneal LD₅₀ = 16 mg kg⁻¹
Mouse
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Subcutaneous LD₅₀ = 37 mg kg⁻¹
Mouse
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Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
No data found
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
May cause anxiety May cause CNS depression May increase heart rate May be harmful if absorbed through the skin
May generate toxic or irritating fumes if heated to decomposition IMDG Transport Hazard Class 6.1
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Not listed (Not listed)
UN1544
Packaging Group II (moderate danger)
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yohimbine
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Record last updated:
21/06/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242