Ciclosporin A |
Last updated: 19/01/2024 |
(Also known as: cicylosporin; ciclosporin) |
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A steroid-sparing immunosuppressant veterinary medication | |
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Current | |
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Used to treat some inflammatory illnesses especially skin conditions such as psoriasis and dermatitis as well as nflammatory conditions such as ulcerative colitis and rheumatoid arthritis | |
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Cats; Dogs; Horses |
Approval status |
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Approved | |
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Approved |
Chemical structure |
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Isomeric | |
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C₆₂H₁₁₁N₁₁O₁₂ | |
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CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)CC=CC)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C | |
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CCC1C(=O)N(CC(=O)N(C(C(=O)NC(C(=O)N(C(C(=O)NC(C(=O)NC(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N(C(C(=O)N1)C(C(C)C/C=C/C)O)C)C(C)C)C)CC(C)C)C)CC(C)C)C)C)C)CC(C)C)C)C(C)C)CC(C)C)C)C | |
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PMATZTZNYRCHOR-IMVLJIQESA-N | |
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InChI=1S/C62H111N11O12/c1-25-27-28-40(15)52(75)51-56(79)65-43(26-2)58(81)67(18)33-48(74)68(19)44(29-34(3)4)55(78)66-49(38(11)12)61(84)69(20)45(30-35(5)6)54(77)63-41(16)53(76)64-42(17)57(80)70(21)46(31-36(7)8)59(82)71(22)47(32-37(9)10)60(83)72(23)50(39(13)14)62(85)73(51)24/h25,27,34-47,49-52,75H,26,28-33H2,1-24H3,(H,63,77)(H,64,76)(H,65,79)(H,66,78)/b27-25+ | |
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Yes |
General status |
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Medicinal drug | |
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Unclassified medicinal drug | |
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Synthetic | |
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Calcineurin inhibitor | |
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[Calcium signal-modulating cyclophilin ligand, Binder], [Calcineurin subunit B type 2, Inhibitor], [Peptidyl-prolyl cis-trans isomerase A, inhibitor], [Peptidyl-prolyl cis-trans isomerase F, mitochondrial, Binder] | |
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59865-13-3 | |
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611-907-1 | |
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5284373 | |
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Antiineoplastic & immunomodulating agents: Calcineurin inhibitors; Sensory organs: Other ophthalomologicals | |
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QL04AD01; QS01XA18 | |
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No | |
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30-ethyl-33-[(E)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone | |
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30-ethyl-33-[(E)-1-hydroxy-2-methylhex-4-enyl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21-di(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone | |
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White powdery solid |
Formulations |
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Atopica 10 mg soft capsules for dogs | Elanco GmbH | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | ||||||
Cyclavance 100 mg/ml Oral Solution for Dogs and Cats | Virbac | GB National authorisation | Prescription only medicine to be authorised by a veterinarian (POM-V) | |||||||
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Often formulated as capsules or liquids for oral administration |
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28.6 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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148 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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8.32 X 1002 | Calculated | - | |||||||
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2.92 | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Degradation |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
Soil adsorption and mobility |
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Fate indices |
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Known metabolites |
None
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Terrestrial ecotoxicology |
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1480 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
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Aquatic ecotoxicology |
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General |
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1480 | Q3 Q = Miscellaneous data from online sources Rat3 = Unverified data of known source |
Moderate | ||||||||
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Metabolised by liver and elminated via bile in around 24 hrs | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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CLP data - known carcinogen May cause stomach disturbance, contractions and diarrhea May elevate blood pressure |
Handling issues |
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Incompatible with strong oxidising agents | |||
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Health: H302, H350, H360fd | |||
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Not listed (Not listed) | |||
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Not registered | |||
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Store at 25 DegC. Do not refridgerate. Generally chemically stable |
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ciclosporin A | ||
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Record last updated: | 19/01/2024 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |