Albendazole
Last updated: 14/09/2023
(Also known as: SLA 3505; SKF-62979)
A potent anthelmintic insecticide. It has a low aqueous solubility. Little has been published regarding its behaviour in the environment or its toxicity to fauna and flora. It is moderately toxic to humans and may cause reproduction or fertility problems. .
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Primary use is as a topical pesticide for livestock for control of parasites in particular various worm infestations.
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1977, UK
Domestic and farm animals including cattle & sheep
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C₁₂H₁₅N₃O₂S
CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC
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HXHWSAZORRCQMX-UHFFFAOYSA-N
InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
albendazole
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Insecticide, Antiparasitic, Anthelmintic
Benzimidazole
>98%
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Synthetic
Causes degenerative alterations in parasite cell walls, inhibiting tubulin polymerization which results in the loss of cytoplasmic microtubules.
[Tubulin alpha-3 chain, antagonist], [Tubulin beta-2C chain, antagonist], [Fumarate reductase flavoprotein subunit, antagonist]
54965-21-8
259-414-7
None allocated
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2082
QP52AC11
Antiparasitic products, insecticides & repellents: Anthelmintics
No
Allowed substance (Table 1: Ruminants)
265.33
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methyl N-(6-propylsulfanyl-1H-benzimidazol-2-yl)carbamate
5-(propylthio)-1H-benzimidazol-2-yl, methyl ester carbamic acid
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Off-white crystalline powder
Albenil 2.5% SC Oral Suspension
Virbac Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Albensure 10% Oral Supension
Animax Ltd
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Endospec SC Oral Suspension
Cross Vetpharm Group
UK National authorisation
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Ovispec SC Oral Suspension
Janssen-Cilag Ltd
UK National authorisation (IC)
Prescription only medicine to be authorised by suitably qualified person (POM-VPS)
Usually administered orally as tablets or solution
0.56
R4 R = Peer reviewed scientific publications 4 = Verified data
Low
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209
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1.86 X 1001
Calculated
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1.27
Low
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10.26
R4 R = Peer reviewed scientific publications 4 = Verified data
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pKa(2) = 2.80
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Soil adsorption and mobility
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Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Non-mobile
17650
Literature range 7800-27500
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Known soil and groundwater metabolites
None
albendazole sulfoxide
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Human (Liver)
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albendazole sulfone
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Human (Liver)
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Terrestrial ecotoxicology
1320
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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1320
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Rat
Moderate
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Intravenous LD₅₀ = 265 mg kg⁻¹
Rat
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0.005
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
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Rapidly metabolised and lost via (probably) biliary excretion. Little is found in the urine.
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Carcinogen
Endocrine disruptor
No data found
A3 A = Chromosome aberration (EFSA database) 3 = Negative
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E1 E = Unspecified genotoxicity type (miscellaneous data source) 1 = Positive
?Possibly, status not identified
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Mutagenic potential Possible tetragenic effect Possible liver toxicant
No information available
Health: H315, H319, H335, H360, H361 Environment: H400, H410
Not listed (Not listed)
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albendazole
albendazole
Albendazol
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albendazol
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albendazol
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Record last updated:
14/09/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242