Menadione (Ref: MSB) |
Last updated: 11/05/2024
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(Also known as: menadione sodium bisulphite; menadione sodium bisulfite; menadione sodium hydrogen sulfgite; vikasol trihydrate; vitamin K3) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate |
Ecotoxicity |
Human health |
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A plant-derived substance used to increase the growth of many plants including tomatoes and alfalfa callus. Substance may also have novel applications |
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Enhances growth |
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Tomatoes; Alfalfa callus; Mungbeans |
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Current |
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1940, first approved US |
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- |
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Not approved |
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Not applicable |
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No UK approval for use as a pesticide |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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None |
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C₁₁H₁₅NaO₈S |
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CC1(CC(=O)C2=CC=CC=C2C1=O)S(=O)(=O)[O-].[Na+] |
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- |
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XDPFHGWVCTXHDX-UHFFFAOYSA-M |
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InChI=1S/C11H10O5S.Na/c1-11(17(14,15)16)6-9(12)7-4-2-3-5-8(7)10(11)13;/h2-5H,6H2,1H3,(H,14,15,16);/q;+1/p-1 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
menadione |
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Plant Growth Regulator |
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Polycyclic aromatic ketone compound; Plant-derived substance |
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Natural |
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Effects auxin metabolism |
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Menadione is a natural product found in various plants including Asplenium yoshinagae and Allium stipitatum |
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It is an intermediate in the chemical synthesis of vitamin K |
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Crop production - Growth |
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- |
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Tomatoes; Alfalfa callus; Mungbeans |
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- |
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57414-02-5 |
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204-987-0 |
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- |
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- |
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4055 |
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330.29 |
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- |
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2-methylnaphthalene-1,4-dione sodium salt |
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1,2,3,4-tetrahydro-2-methyl-1,4-dioxo-2-naphthalenesulfonic acid sodium salt |
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- |
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- |
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Not known |
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Not known |
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Not applicable |
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Not applicable |
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- |
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Yellowish white crystalline hygroscopic powder |
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50000 |
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High |
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102 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Decomposed by sunlight |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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1250 |
Rat |
Moderate |
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Non-toxic |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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1250 |
Rat |
Moderate |
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1830 |
Mouse (as TDLo) |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
✓Yes, known to cause a problem |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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Kidney and liver toxicant May weaken the immune system May cause allergic reactions and eczema Blood coagulant Rare incidences of neonatal brain/liver damage and neonatal death have been reported |
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Protect from moisture |
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Not listed (Not listed) |
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menadione |
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bisulfite sodique de menadione |
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bisulfito sodico de menadiona |
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Record last updated: |
11/05/2024 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |