4-allylanisole |

Last updated: 27/08/2025
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(Also known as: p-allylanisole; methyl chavicol; estragol; estragole; 4-allylmethoxybenzene) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate |
Ecotoxicity |
Human health |
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A naturally occurring chemical that acts as a beetle repellent when applied to trees by signalling a food and habitat source |
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Bark beetles including the southern pine beetle (Dendroctonus frontalis) |
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Conifer trees |
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- |
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- |
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- |
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Not approved |
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Not applicable |
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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4-allylanisole is an isomer of anethole |
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C₁₀H₁₂O |
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COC1=CC=C(C=C1)CC=C |
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- |
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ZFMSMUAANRJZFM-UHFFFAOYSA-N |
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InChI=1S/C10H12O/c1-3-4-9-5-7-10(11-2)8-6-9/h3,5-8H,1,4H2,2H3 |
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Yes |
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Insecticide; Semiochemical |
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Plant-derived substance; Pheromone |
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- |
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Natural |
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Contact |
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Produced by certain conifer trees in response to wounding or poor environmental conditions and is also present in large quantities in certain herbs such as basil, tarragon, fennel and tarragon |
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Forestry |
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Bark beetles including the southern pine beetle (Dendroctonus frontalis) |
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Conifer trees |
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- |
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140-67-0 |
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205-427-8 |
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- |
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062150 |
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8815 |
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148.2 |
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- |
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1-methoxy-4-(2-propenyl)benzene |
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4-allyl-1-methoxybenzene |
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- |
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FEMA=2411; FLAVIS=01.015 |
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- |
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Not applicable |
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Not applicable |
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Not known |
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Not applicable |
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- |
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Colourless liquid with an aniseed odour |
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Current |
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1990s, discovered; 2001, first registered USA |
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For agriculture the substance is supplied in a variety of formulations including wettable powders, emulsifiable concentrates and seed treatments. It is typically used as a foliar spray or soil drench |
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4-Allylanisole is produced commercially through chemical synthesis using anethole and methanol. Anethole is isomerised to produce 4-allylanisole. This process involves the rearrangement of the molecular structure of anethole to form 4-allylanisole. The crude 4-allylanisole is purified using techniques such as distillation to remove impurities and obtain a high-purity product for formulation. It may also be produced from the fractional distillation of oil of turpentine. The process involves fractional distillation of the oil of turpentine to isolate 4-allylanisole. |
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While exact CO₂e values are not published for specific pheromones, some general information is available. The PHERA reported that biotechnological production (e.g. yeast fermentation) of pheromones can reduce GHG emissions by up to 90% compared to traditional chemical synthesis and GHG emissions are typically in the 5 to 10 kg CO₂e per kg of pheromone produced. Other sources suggest that small scale pheromone synthesis typically has emissions in the range 1 – 3 kg CO₂e per kg of pheromone produced. |
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178 |
at 25 °C |
Moderate |
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216 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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2.95 X 1003 |
Calculated |
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3.47 |
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High |
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0.965 |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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> 1230 |
Rat |
Moderate |
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R2 R = Peer reviewed scientific publications 2 = Unverified data of unknown source Toxic |
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R2 R = Peer reviewed scientific publications 2 = Unverified data of unknown source Toxic |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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> 1230 |
Rat |
Moderate |
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5000 |
Rabbit |
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Intraperitoneal LD₅₀ = 1030 mg kg⁻¹ |
Rat |
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Exposure may occur via skin or inhalation - PPE/PPC advised |
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Carcinogen |
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Endocrine disruptor |
?Possibly, status not identified |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
?Possibly, status not identified |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
✓Yes, known to cause a problem |
✓Yes, known to cause a problem |
?Possibly, status not identified |
Eye irritant |
Phototoxicant |
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✓Yes, known to cause a problem |
No data found |
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May cause dermatitis May cause gastrointestinal irritation with nausea, vomiting and diarrhoea Genotoxic CLP data - suspected carcinogen |
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Flammable Incompatible with strong oxidizing agents |
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Health: H302, H315, H317, H319, H341, H351 Environment: H412 |
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Not listed (Not listed) |
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4-allylanisole |
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Record last updated: |
27/08/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |