Precocene II |

Last updated: 27/08/2025
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(Also known as: precocene 2 ; ageratochromene) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate |
Ecotoxicity |
Human health |
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A botanically derived insect growth regulator used to control a range of insects. Also reported to have some fungicidal activity |
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Cockroaches; Aphids; Beetles; Fleas and ticks |
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Not approved |
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Not applicable |
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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None |
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C₁₃H₁₆O₃ |
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CC1(C=CC2=CC(=C(C=C2O1)OC)OC)C |
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No data |
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PTIDGSWTMLSGAH-UHFFFAOYSA-N |
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InChI=1S/C13H16O3/c1-13(2)6-5-9-7-11(14-3)12(15-4)8-10(9)16-13/h5-8H,1-4H3 |
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Yes |
Cambridge Crystallographic Data Centre diagrams |
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Common Name |
Relationship |
Link |
precocene II |
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Insecticide; Fungicide; Insect Growth Regulator |
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Plant-derived substance |
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Natural |
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Inhibits juvenile hormone biosynthesis |
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Compound derived from oil obtained from the annual bedding plant Ageratum houstonianum. It is also found in various botanical essential oils |
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General pest management |
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Cockroaches; Aphids; Beetles; Fleas and ticks |
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644-06-4 |
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211-408-5 |
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12565 |
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220.27 |
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6,7-dimethoxy-2,2-dimethylchromene |
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6,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran |
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Not applicable |
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Not applicable |
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Not known |
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Not applicable |
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Pale yellow crystals |
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Current |
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- Cayman Chemicals USA
- Hubei Wande Chemicals China
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Usually supplied as an emulsifiable concentrate and liquid prducts for use as foliar sprays |
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Precocene II is typically produced through a chemical synthesis process. One common method involves the alkylation of 2,2-dimethyl-2H-chromene (also known as 1,2,4-benzotriol), which is a precursor for precocene II. The alkylated intermediate is then subjected to cyclization. This step forms the core chromene structure of precocene II. The final product is purified, often through recrystallization or chromatography, to obtain pure precocene II. |
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While exact GHG emission figures for precocene II are not available, very rough estimates based on similar production processes suggest a very rough value of 4.8-5.8 tonnes CO₂e per kg of product, depending on process efficiency, energy source, and waste treatment. |
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46 |
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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8.51 X 1002 |
Calculated |
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2.93 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
Moderate |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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Soil adsorption and mobility |
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Known soil and groundwater metabolites |
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None
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6,7-dimethoxy2,2-dimethyl-chroman3,4-diol |
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Insects |
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Terrestrial ecotoxicology |
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> 3500 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rat |
Low |
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HUMAN HEALTH AND PROTECTION |
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High (class III) |
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> 3500 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Rat |
Low |
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Carcinogen |
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Endocrine disruptor |
No data found |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data |
No data found |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
No data found |
No data found |
No data found |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
?Possibly, status not identified |
?Possibly, status not identified |
No data found |
Eye irritant |
Phototoxicant |
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?Possibly, status not identified |
No data found |
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Possible kidney, liver and bladder toxicant May cause irritation of the digestive tract |
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Prevent generation of dust |
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Not listed (Not listed) |
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Store in the dark at 0-4 DegC for short term and at -20 DegC for long term. |
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precocene II |
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precocene II |
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Record last updated: |
27/08/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |