Looplure (Ref: ENT 33266) |

Last updated: 23/08/2025
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(Also known as: Straight Chain Lepidopteran Pheromone; Cabbage looper moth sex pheromone; Tomato looper moth sex pheromone; Z7-12Ac; Cabblemone) |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate |
Ecotoxicity |
Human health |
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A volatile substance that is classed as a Straight Chain Lepidoptera pheromone (SCLP) and used as an insect attractant |
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Tomato looper moths (Chrysodeixis chalcites) |
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Vegetables; Tomatoes |
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- |
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- |
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- |
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Not approved |
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Not applicable |
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved |
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Not applicable |
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Not applicable |
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Not applicable |
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No |
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ATAustria |
BEBelgium |
BGBulgaria |
CYCyprus |
CZCzech Republic |
DEGermany |
DKDenmark |
EEEstonia |
ELGreece |
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ESSpain |
FIFinland |
FRFrance |
HRCroatia |
HUHungary |
IEIreland |
ITItaly |
LTLithuania |
LULuxembourg |
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LVLatvia |
MTMalta |
NLNetherlands |
PLPoland |
PTPortugal |
RORomania |
SESweden |
SISlovenia |
SKSlovakia |
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ISIceland |
NONorway |
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Looplure exhibits geometrical isomerism due to the presence of a double bond at the 7th carbon in its 12-carbon chain. This double bond allows for cis-trans (Z/E) isomerism, where the Z-isomer (cis) has both substituents on the same side of the double bond, which is the biologically active form. The E-isomer (trans) has a different spatial configuration and is significantly less biologically effective. The specificity and efficacy of looplure in pest control depend entirely on this precise Z-configuration, as it matches the olfactory receptors of target insects. |
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C₁₄H₂₆O₂ |
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CCCCC=CCCCCCCOC(=O)C |
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CCCC/C=C\CCCCCCOC(=O)C |
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MUZGQHWTRUVFLG-SREVYHEPSA-N |
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InChI=1S/C14H26O2/c1-3-4-5-6-7-8-9-10-11-12-13-16-14(2)15/h6-7H,3-5,8-13H2,1-2H3/b7-6- |
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Yes |
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Insecticide; Semiochemical |
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Pheromone |
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- |
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- |
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Natural |
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Functions as an insect attractant - mating disrupter |
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Originally extracted from virgin female tomato looper moths (Chrysodeixis chalcites) and female cabbage looper moths (Trichoplusia ni) |
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Crop protection |
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Tomato looper moths (Chrysodeixis chalcites) |
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Vegetables; Tomatoes |
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Suitable for use in all farming systems where approved for use in that country |
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14959-86-5 |
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239-031-1 |
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- |
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- |
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- |
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226.36 |
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- |
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(E)-7-dodecen-1-yl acetate |
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(E)-7-dodecen-1-ol acetate |
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- |
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- |
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- |
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Not applicable |
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Not applicable |
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Not known |
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Not applicable |
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- |
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Colourless to pale yellow liquid |
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Current |
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1966, isolation published |
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- |
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- |
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Usually supplied in slow release formulations and devices |
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Looplure is commercially produced through a multi-step synthetic process that typically involves a nucleophilic substitution reaction, where a Grignard reagent derived from a protected bromohydrin reacts with (Z)-2-hepten-1-yl acetate in the presence of a copper(I) iodide catalyst. This method ensures the formation of the desired (Z)-isomer, which is critical for biological activity. |
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While exact CO₂e values are not published for specific pheromones, some general information is available. The PHERA reported that biotechnological production (e.g. yeast fermentation) of pheromones can reduce GHG emissions by up to 90% compared to traditional chemical synthesis and GHG emissions are typically in the 5 to 10 kg CO₂e per kg of pheromone produced. Other sources suggest that small scale pheromone synthesis typically has emissions in the range 1 – 3 kg CO₂e per kg of pheromone produced. |
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0.568 |
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Low |
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- |
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- |
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- |
- |
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- |
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- |
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3.63 X 1005 |
Calculated |
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5.56 |
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High |
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- |
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. |
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- |
Soil adsorption and mobility |
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None
Terrestrial ecotoxicology |
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13230 |
Rat |
Low |
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- |
- |
- |
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- |
- |
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- |
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> 2500 |
No adverse effects identified or expected |
Low |
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> 1000 |
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source Expert judgement |
Low |
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- |
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> 100 |
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source Expert judgement |
Low |
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> 100 |
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source Oncorhynchus mykiss |
Low |
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- |
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- |
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> 100 |
No adverse effects identified or expected |
Low |
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HUMAN HEALTH AND PROTECTION |
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Low (class I) |
- |
- |
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13230 |
Rat |
Low |
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2025 |
Rabbit |
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> 4.5 |
Rat |
- |
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Carcinogen |
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Endocrine disruptor |
XNo, known not to cause a problem |
A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative |
XNo, known not to cause a problem |
Reproduction / development effects |
Acetyl cholinesterase inhibitor |
Neurotoxicant |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
Respiratory tract irritant |
Skin irritant |
Skin sensitiser |
XNo, known not to cause a problem |
XNo, known not to cause a problem |
No data found |
Eye irritant |
Phototoxicant |
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XNo, known not to cause a problem |
No data found |
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No adverse human health issues identified |
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Not explosive or oxisiding |
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- |
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Not listed (Not listed) |
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Not regulated |
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looplure |
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Record last updated: |
23/08/2025 |
Contact: |
aeru@herts.ac.uk |
Please cite as: |
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |