L-ascorbic acid |
![]() Last updated: 10/06/2022 |
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(Also known as: Vitamin C; ascorbic acid; 3-oxo-1-gulofuranolactone) |
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Substance with fungicide and bactericide action against Phytophthora infestans in potatoes, fusarium in ornamentals and botrytis in greenhouse tomatoes | |
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Current | |
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2011, as pesticide; first discovered 18thC | |
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UK regulatory status |
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Approved | ||
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30/09/2024 | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Netherlands | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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30/09/2024 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Chemical structure |
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Ascorbic acid exists as two enantiomers commonly refrred to as L-ascorbic acide and D-ascorbic acid. The L-isomer is the more common. | |
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C₆H₈O₆ | |
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C(C(C1C(=C(C(=O)O1)O)O)O)O | |
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C([C@@H]([C@@H]1C(=C(C(=O)O1)O)O)O)O | |
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CIWBSHSKHKDKBQ-JLAZNSOCSA-N | |
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InChI=1S/C6H8O6/c7-1-2(8)5-3(9)4(10)6(11)12-5/h2,5,7-10H,1H2/t2-,5+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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L-ascorbic acid | - | ![]() |
General status |
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Fungicide, Bactericide | |
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Unclassified pesticide | |
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>990 g kg⁻¹ | |
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EU dossier - methanol <3g kg⁻¹; heavy metals 0.01g kg⁻¹ | |
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Natural | |
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Systemic, protective, stimulates the natural defence mechanisms and wound healing processes in plants | |
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A naturally occurring substance that can be isolated from synergistic vitamin C complexes found in living nutrient sources | |
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Manufactered for commercial use from corn or refined sugar | |
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Crop protection | |
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Phytophthora infestans, fusarium spp. in ornamentals and botrytis spp. | |
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Various crops including potatoes, tomatoes and ornamentals | |
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50-81-7 | |
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200-066-2 | |
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774 | |
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176.1 | |
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(5R)-[(1S)-1,2-dihydroxyethyl]-3,4-dihydroxyfuran-2(5H)-one | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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NC | |
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White powder |
Formulations |
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Usually supplied as a soluble liquid |
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330000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Ether5 = Verified data used for regulatory purposes |
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Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Benzene5 = Verified data used for regulatory purposes |
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Insoluble | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Chloroform5 = Verified data used for regulatory purposes |
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50000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Propylene glycol5 = Verified data used for regulatory purposes |
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190 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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190 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.32 X 10-02 | Calculated | - | |||||||
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-1.88 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low | ||||||||
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pH 6.4: max @ 265nm pH 2: max @ 245nm |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Not surface active | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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15 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source |
Fast | ||||||||
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Soil adsorption and mobility |
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Other known metabolites |
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ascorbate-2-sulphate | - | Humans | - | - | |||||
oxalic acid | - | Humans | - | - | |||||
dehydroascorbic acid | - | Humans | - | - |
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Terrestrial ecotoxicology |
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11900 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
Low | ||||||||
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> 250 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Gallus domesticus as NOEL3 = Unverified data of known source |
Moderate | ||||||||
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> 1000 | Q2 Q = Miscellaneous internet resources Expert judgement2 = Unverified data of unknown source |
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> 4.5 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera3 = Unverified data of known source |
Moderate | |||||||
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> 15.9 | A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera3 = Unverified data of known source |
Moderate | ||||||||
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> 0.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Aphidius rhopalosiphi5 = Verified data used for regulatory purposes |
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9.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Typhlodromus pyri5 = Verified data used for regulatory purposes |
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> 17 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Poecilus cupreus5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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> 2000 | Q2 Q = Miscellaneous internet resources Unknown species2 = Unverified data of unknown source |
Low | ||||||||
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2000 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Oreochromis niloticus 3 = Unverified data of known source |
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General |
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Low (class I) | - | - | ||||||||
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11900 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
Low | ||||||||
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Intravenous LD₅₀ = 518 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Mouse3 = Unverified data of known source |
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Subcutaneous LD₅₀ = 10000 mg kg⁻¹ | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) Rat3 = Unverified data of known source |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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None allocated | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Considered safe | |||||||||
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Considered safe | ||||||||||
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Readily absorbed and excreted mainly in the urine in humans and via the lungs in rats and guinea pigs | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Excessive consumption may cause diarrhoea and behavioural effects |
Handling issues |
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Not explosive or oxidising Not expected to autoignite; Not highly flammable |
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Health: H315, H318, H319 | |||
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NL (Not listed) | |||
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None | |||
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L-ascorbic acid | ||
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acide ascorbique | ||
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acidum ascorbicum | ||
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acido ascorbico | ||
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Record last updated: | 10/06/2022 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |