Nemadectin |
![]() Last updated: 24/08/2025 |
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(Also known as: S541A; LL-F28249 aplha) |
Hazard alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.
Environmental fate | Ecotoxicity | Human health |
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A naturally occurring substance with broad-spectrum antiparasitic properties | |
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Shown to be efficacy against the natural canine-infecting helminth parasitic worms and ivermectin-resistant barber's pole worm (Haemonchus contortus) in sheep | |
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Dogs; Sheep | |
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GB regulatory status |
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Not applicable | ||
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Not applicable | ||
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No UK approval for use as a plant protection agent |
EC Regulation 1107/2009 (repealing 91/414) |
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Additional information |
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Chemical structure |
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Nemadectin exhibits extensive stereoisomerism, including both optical and geometrical isomerism, due to its large, complex ring system and multiple stereocentres. | |
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C₃₆H₅₂O₈ | |
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CC1CC(=CCC2CC(CC3(O2)CC(C(C(O3)C(=CC(C)C)C)C)O)OC(=O)C4C=C(C(C5C4(C(=CC=C1)CO5)O)O)C)C | |
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C[C@@H]\1C/C(=C/C[C@@H]2C[C@@H](C[C@@]3(O2)C[C@@H]([C@@H]([C@H](O3)/C(=C/C(C)C)/C)C)O)OC(=O)[C@@H]4C=C([C@H]([C@@H]5[C@]4(/C(=C/C=C1)/CO5)O)O)C)/C | |
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YNFMRVVYUVPIAN-AQUURSMBSA-N | |
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InChI=1S/C36H52O8/c1-20(2)13-24(6)32-25(7)30(37)18-35(44-32)17-28-16-27(43-35)12-11-22(4)14-21(3)9-8-10-26-19-41-33-31(38)23(5)15-29(34(39)42-28)36(26,33)40/h8-11,13,15,20-21,25,27-33,37-38,40H,12,14,16-19H2,1-7H3/b9-8+,22-11+,24-13+,26-10+/t21-,25-,27+,28-,29-,30-,31+,32+,33+,35-,36+/m0/s1 | |
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Yes |
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Common Name | Relationship | Link |
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nemadectin | - | ![]() |
General status |
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Nematicide; Insecticide; Antibiotic; Veterinary substance | |
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Micro-organism derived substance | |
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Natural | |
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Nemadectin is a natural substance produced by Streptomyces microflavus and Streptomyces griseus | |
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Pest management | |
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Shown to be efficacy against the natural canine-infecting helminth parasitic worms and ivermectin-resistant barber's pole worm (Haemonchus contortus) in sheep | |
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Dogs; Sheep | |
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102130-84-7 | |
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612.80 | |
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(1'R,2R,4S,4'S,5S,6S,8'R,10'E,13'R,14'E,16'E,20'R,21'R,24'S)-4,21',24'-trihydroxy-5,11',13',22'-tetramethyl-6-[(2E)-4-methyl-2-penten-2-yl]-3,4,5,6-tetrahydro-2'H-spiro[pyran-2,6'-[3,7,19]trioxatetracyclo[15.6.1.1~4,8~.0~20,24~]pentacosa[10,14,16,22]tetraen]-2'-one | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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White solid |
Commercial |
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Nemadectin is commercially produced through a fermentation process using Streptomyces cyaneogriseus subspecies noncyanogenus The production involves cultivating this microorganism under controlled conditions optimised for yield, including nutrient-rich media and precise temperature and pH settings. After fermentation, the compound is extracted and purified for use. | |||
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As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below. | ||||||||||
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Known metabolites |
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Terrestrial ecotoxicology |
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Aquatic ecotoxicology |
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General |
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Mainly excreted in the faeces | Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source |
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Health issues |
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Possible liver toxicant at high doses |
Handling issues |
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IMDG Transport Hazard Class 6.1 | |||
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Not listed (Not listed) | |||
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UN2588 | |||
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Packaging Group III (minor danger) | |||
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nemadectin | ||
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nemadectin | ||
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nemadectina | ||
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Record last updated: | 24/08/2025 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |