Hydrolysed proteins	Last updated: 14/02/2026
(Not known by any other names)

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Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate	PHT: Ecotoxicity	PHT: Human health	Highly Hazardous Pesticide
		Human health Low alert

GENERAL INFORMATION

Description	Used mainly as a bait trap for adults flying insects in trees
Example pests controlled	Olive and fruit flies (Bactrocera oleae, Ceratitis capitata, Rhagoletis cerasi) and other species of Diptera flies and mosquitoes
Example applications	Olive trees; Citrus; Fruit trees including, apple, pears and plum; Figs; Walnuts; Blueberries
Efficacy & activity	Field trials have demonstrated strong attractant effects
Appearance and life cycle	-
Taxonomic classification	-

GB regulatory status

GB COPR regulatory status	Not approved
Date COPR inclusion expires	Withdrawn
GB LERAP status	No UK approval for use as a plant protection agent

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status	Approved
Dossier rapporteur/co-rapporteur	Spain/Greece
Date EC 1107/2009 inclusion expires	30/04/2039
EU Candidate for substitution (CfS)	No
Listed in EU database	Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States	ATAustria BEBelgium BGBulgaria CYCyprus CZCzech Republic DEGermany DKDenmark EEEstonia ELGreece       ✓         ✓ ESSpain FIFinland FRFrance HRCroatia HUHungary IEIreland ITItaly LTLithuania LULuxembourg ✓   ✓       ✓     LVLatvia MTMalta NLNetherlands PLPoland PTPortugal RORomania SESweden SISlovenia SKSlovakia   ✓     ✓
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries	ISIceland NONorway

Additional information

Also used in	Egypt; Morocco

Chemical structure

Isomerism	Not applicable
Chemical formula	-
Canonical SMILES	-
Isomeric SMILES	-
International Chemical Identifier key (InChIKey)	-
International Chemical Identifier (InChI)	-
2D structure diagram/image available?	No

General status

Biopesticide type		Insecticide; Attractant
Substance groups		Unclassified pesticide; Plant- and animal-derived
Minimum active substance purity		Product dependent 252-360 g kg⁻¹
Known relevant impurities		-
Substance origin		Natural; Complex mixture
Mode of action		Attractant - odour associated with emissions of volatile substances
Substance source		Sourced mainly from whey, casein, soy and collagen
Mixture composition		Hydrolysed proteins are defined not by a single molecule but by a mixture of peptides, free amino acids, and residual protein fragments produced through enzymatic or acid hydrolysis. Their pesticidal activity is tied to volatile amino acid breakdown products (attractants), peptide based feeding stimulants, and in some cases chemosensory disruption. Peptides are the dominant fraction (approx. 40–70% of dry material), free amino acids, a key bioactive class account for 10-30%. There are also small amounts of ammoniacal and volatile nitrogen compounds as well as residual intact proteins.
Uses		Crop protection
Target pests		Olive and fruit flies (Bactrocera oleae, Ceratitis capitata, Rhagoletis cerasi) and other species of Diptera flies and mosquitoes
Target host		Olive trees; Citrus; Fruit trees including, apple, pears and plum; Figs; Walnuts; Blueberries
Farming system suitability		-
CAS RN		-
EC number		-
CIPAC number		901
US EPA chemical code		-
PubChem CID		-
Molecular mass		-
Chemical name		hydrolysed proteins
PIN (Preferred Identification Name)		-
IUPAC name		-
CAS name		-
Global Governance status: Listed (✓) under		UK Poisons List Order 1972 Rotterdam Convention Montreal Protocol XNo The Poisons List Order 1972 XNo Rotterdam Convention XNo Montreal Protocol Stockholm Convention OSPAR EU Water Framework Directive XNo Stockholm Convention XNo OSPAR XNo EU Water Framework Directive
Relevant Environmental Water Quality Standards		-
Forever chemical		-
Highly Hazardous Pesticide (HHP)	Type I	-
	Type II	-
Other status information		-
Herbicide Resistance Class (HRAC MoA class)		Not applicable
Herbicide Resistance Class (WSSA MoA class)		Not applicable
Insecticide Resistance Class (IRAC MoA class)		Not known
Fungicide Resistance Class (FRAC MOA class)		Not applicable
Examples of recorded resistance		-
Physical state		Dark brown liquid comprised of amino acids and peptides

Commercial

Property	Value
Availability status	Current
Introduction & key dates	Circa 2008-2009, first products registered
Example manufacturers & suppliers of products using this active now or historically	Bioiberica, Spain CPCM
Example products using this active	Biocebo Pick-up Blouz
Formulation and application details	Used in insect traps
Commercial production	Produced by enzymatic hydrolysis of whole protein sources by proteolytic enzymes under controlled conditions, followed by post-hydrolysis processing to isolate the protein hydrolysates
Impact on climate of production and use	-

ENVIRONMENTAL FATE

Property		Value	Source; quality score; and other information	Interpretation
Solubility - In water at 20 °C at pH 7 (mg l⁻¹)		1000000	A3 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 3 = Unverified data of known source	High
Solubility - In organic solvents at 20 °C (mg l⁻¹)		-	-	-
Melting point (°C)		-	-	-
Boiling point (°C)		100	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data approx. value	-
Degradation point (°C)		-	-	-
Flashpoint (°C)		-	-	-
Octanol-water partition coefficient at pH 7, 20 °C	P	-	-	-
	Log P	-	-	-
Fat solubility of residues	Solubility	-	-	-
	Data type	-	-	-
Density (g ml⁻¹)		1.14	A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 4 = Verified data	-
Dissociation constant pKa) at 25 °C		-	-	-
		-
Vapour pressure at 20 °C (mPa)		-	-	-
Henry's law constant at 25 °C (Pa m³ mol⁻¹)		-	-	-
Volatilisation as max % of applied dose lost	From plant surface	-	-	-
	From soil surface	-	-	-
Maximum UV-vis absorption L mol⁻¹ cm⁻¹		-	-	-
Surface tension (mN m⁻¹)		-	-	-

Degradation

Property		Value	Source; quality score; and other information	Interpretation
General biodegradability		Highly biodegradable
Soil degradation (days) (aerobic)	DT₅₀ (typical)	-	-	-
	DT₅₀ (lab at 20 °C)	-	-	-
	DT₅₀ (field)	-	-	-
	DT₉₀ (lab at 20 °C)	-	-	-
	DT₉₀ (field)	-	-	-
	DT₅₀ modelling endpoint	-	-	-
	Note	-
Dissipation rate RL₅₀ (days) on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL₅₀ (days) on and in plant matrix	Value	-	-	-
	Note	-
Aqueous photolysis DT₅₀ (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7	Value	-	-	-
	Note	-
Water-sediment DT₅₀ (days)		-	-	-
Water phase only DT₅₀ (days)		-	-	-
Sediment phase only DT₅₀ (days)		-	-	-
Air degradation		As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀		-

Soil adsorption and mobility

Property		Value	Source; quality score; and other information	Interpretation
Linear	Kd (mL g⁻¹)	-	-	-
	Koc (mL g⁻¹)	-
	Notes and range	-
Freundlich	Kf (mL g⁻¹)	-	-	-
	Kfoc (mL g⁻¹)	-
	1/n	-
	Notes and range	-
pH sensitivity		-

Known metabolites

None

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property		Value	Source; quality score; and other information	Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		-	-	-
Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Birds - Acute LD₅₀ (mg kg⁻¹)		-	-	-
Birds - Short term dietary LC₅₀ (mg kg⁻¹ bw d⁻¹)		-	-	-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)		-	-	-
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)		-	-	-
Soil micro-organisms		-	-	-
Collembola	Acute LC₅₀ (mg kg⁻¹)	-	-	-
	Chronic NOEC (mg kg⁻¹)	-	-	-
Non-target plants	Vegetative vigour ER₅₀ (g ha⁻¹)	-	-	-
	Seedling emergence ER₅₀ (g ha⁻¹)	-	-	-
Honeybees (Apis spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Chronic	-	-	-
	Notes	-
Bumblebees (Bombus spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
		-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
		-
Mason bees (Osmia spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
Other bee species (1)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Other bee species (2)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Beneficial insects (Ladybirds)		-	-	-
Beneficial insects (Lacewings)		-	-	-
Beneficial insects (Parasitic wasps)		-	-	-
Beneficial insects (Predatory mites)		-	-	-
Beneficial insects (Ground beetles)		-	-	-
Beneficial insects (Butterflies)	Contact	-	-	-
	Notes	-
	Oral	-	-	-
	Notes	-

Aquatic ecotoxicology

Property		Value	Source; quality score; and other information	Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)		-	-	-
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)		-	-	-
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)		-	-	-
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)		-	-	-
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)		-	-	-
Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹)		-	-	-
Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)		-	-	-
Algae - Acute (growth rate, fresh; mg l⁻¹)		-	-	-
Algae - Chronic (growth rate, fresh; mg l⁻¹)		-	-	-
Mesocosm study data	NOEAEC mg l⁻¹	-	-	-
	NOEAEC mg l⁻¹	-	-	-
Marine bivalves		-	-	-

Regulatory Threshold Levels (RTLs) used to calculate Total Applied Toxicity (TAT)

Species group	RTL	Notes
Mammals	No data	No data for acute and chronic mammals
Birds	No data	No data for acute and chronic birds
Soil organisms	No data	No data for acute and chronic earthworms
Terrestrial plants	No data	No data for non-target plants vegetative vigour and seedling emergence
Pollinators	No data	No data for contact and oral honeybees
Arthropods	No data	No data for parasitic wasps and predatory mites
Fish	No data	No data for temperate acute and chronic fish
Aquatic invertebrates	No data	No data for temperate acute and chronic aquatic invertebrates
Aquatic plants	No data	No data for free-floating plants, rooted plants, acute and chronic algae

HUMAN HEALTH AND PROTECTION

General

Property		Value	Source; quality score; and other information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		-	-	-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		-	-	-
Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)		-	-	-
Mammals - Inhalation LC₅₀ (mg l⁻¹)		-	-	-
Other Mammal toxicity endpoints		-	-	-
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)		None allocated	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)		None allocated	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)		None allocated	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)		None allocated	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes	-
Dermal penetration studies (%)		10-50%	A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes concentration dependent	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Routes	Public	Very low risk to bystanders and residents
	Occupational	Very low occupational risk
Mammalian dose elimination route and rate		-	-	-

Health issues

Specific human health issues (hazard-based)		Carcinogen Genotoxic Endocrine disruptor XNo, known not to cause a problem A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data XNo, known not to cause a problem Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant XNo, known not to cause a problem XNo, known not to cause a problem XNo, known not to cause a problem Respiratory tract irritant Skin irritant Skin sensitiser XNo, known not to cause a problem No data found XNo, known not to cause a problem Eye irritant Phototoxicant   No data found No data found
General human health issues		No information available

Handling issues

Property	Value and interpretation
General	Not explosive or oxidising Oily black, thick smoke may be produced in a fire May be unstable in contact with bases Corrosive vapours may be produced during decomopsition
CLP classification 2013	-
WHO Classification	Not listed (Not listed)
UN Number	Not regulated
Waste disposal & packaging	-
Shelf-life, storage, stability and reactivity	-

TRANSLATIONS

Language	Name
English	hydrolysed proteins
French	-
German	-
Danish	-
Italian	-
Spanish	-
Greek	-
Polish	-
Swedish	-
Hungarian	-
Dutch	-
Norwegian	-

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Record last updated:	14/02/2026
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242

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