Spinetoram J (Ref: XDE-175-J )

Spinetoram J (Ref: XDE-175-J )	Last updated: 24/02/2026
(Not known by any other names)

Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate	PHT: Ecotoxicity	PHT: Human health	Highly Hazardous Pesticide
Environmental fate Moderate alert: Potential for particle bound transport: Medium		Human health Moderate alert: Reproduction/development effects	Highly Hazardous Pesticide (HHP) Type II alert

GENERAL INFORMATION

Description

A natural fermentation-derived substance with activity against a wide range of common insect pests

Example pests controlled

Apple moth; Grapevine moth; Codling moth; Oriental fruit moth; Western flower thrip; Pear & cherry slugs

Example applications

Fruit including grapes, apples, pears, apricots, cherries, plums, peaches

Efficacy & activity

Appearance and life cycle

Taxonomic classification

GB regulatory status

GB COPR regulatory status

Not approved

Date COPR inclusion expires

Withdrawn

GB LERAP status

No UK approval for use as a plant protection agent

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Not approved

Dossier rapporteur/co-rapporteur

Croatia/Spain

Date EC 1107/2009 inclusion expires

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
	✓	✓	✓		✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓		✓	✓	✓				✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
		✓	✓		✓		✓

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

USA (pending)

Chemical structure

Isomerism

Spinetoram J is the major component of spinetoram technical material. It is not an isomer of spinetoram but contains an extra methyl group.

Chemical formula

C₄₂H₆₉NO₁₀

Canonical SMILES

CCC1CCCC(C(C(=O)C2=CC3C(C2CC(=O)O1)CCC4C3CC(C4)OC5C(C(C(C(O5)C)OC)OCC)OC)C)OC6CCC(C(O6)C)N(C)C

Isomeric SMILES

CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@@H]3[C@H]([C@@H]2CC(=O)O1)CC[C@H]4[C@H]3C[C@@H](C4)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OCC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C

International Chemical Identifier key (InChIKey)

GOENIMGKWNZVDA-RWGFPKGXSA-N

International Chemical Identifier (InChI)

InChI=1S/C42H69NO10/c1-10-27-13-12-14-35(53-37-18-17-34(43(6)7)24(4)49-37)23(3)38(45)33-21-31-29(32(33)22-36(44)51-27)16-15-26-19-28(20-30(26)31)52-42-41(47-9)40(48-11-2)39(46-8)25(5)50-42/h21,23-32,34-35,37,39-42H,10-20,22H2,1-9H3/t23-,24-,25+,26-,27+,28-,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+/m1/s1

2D structure diagram/image available?

Yes

General status

Biopesticide type

Insecticide

Substance groups

Spinosyn insecticide

Minimum active substance purity

>95%

Known relevant impurities

EU dossier - none declared

Substance origin

Semi-synthetic

Mode of action

Shows high residual, contact and ingestion activity. Nicotinic acetylcholine receptor (nAChR) channel blocker - site I

Substance source

Uses

Crop protection

Target pests

Apple moth; Grapevine moth; Codling moth; Oriental fruit moth; Western flower thrip; Pear & cherry slugs

Target host

Fruit including grapes, apples, pears, apricots, cherries, plums, peaches

Farming system suitability

CAS RN

187166-40-1

EC number

803-245-9

CIPAC number

802

US EPA chemical code

110008

PubChem CID

24795086

CLP index number

No data found

Molecular mass

748.0

PIN (Preferred Identification Name)

IUPAC name

(1S,2R,5R,7R,9R,10S,14R,15S,19S)-15-[(2R,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-7-[(2R,3R,4R,5S,6S)-4-ethoxy-3,5-dimethoxy-6-methyloxan-2-yl]oxy-19-ethyl-14-methyl-20-oxatetracyclo[10.10.0.02,10.05,9]docos-11-ene-13,21-dione

CAS name

Global Governance status: Listed (✓) under

UK Poisons List Order 1972	Rotterdam Convention	Montreal Protocol
XNo The Poisons List Order 1972	XNo Rotterdam Convention	XNo Montreal Protocol
Stockholm Convention	OSPAR	EU Water Framework Directive
XNo Stockholm Convention	XNo OSPAR	XNo EU Water Framework Directive

Relevant Environmental Water Quality Standards

Forever chemical

Highly Hazardous Pesticide (HHP)

Type I

Type II

Yes []

Other status information

PAN listed Highly Hazardous Chemical

Herbicide Resistance Class (HRAC MoA class)

Not applicable

Herbicide Resistance Class (WSSA MoA class)

Not applicable

Insecticide Resistance Class (IRAC MoA class)

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Physical state

Off-white solid

Related substances & organisms

spinetoram

Commercial

Property

Value

Availability status

Current

Introduction & key dates

2007, first registered USA

Example manufacturers & suppliers of products using this active now or historically

Dow AgroSciences
BOC Sciences

Example products using this active

Delegate
Radiant

Formulation and application details

Spinetoram J is not formulated as a standalone, isolated product, but rather as the major component (roughly 3:1 ratio with spinetoram L) in the technical material and commercial pesticide formulations.

Commercial production

Spinetoram J is not manufactured through a single chemical synthesis but through a semi synthetic upgrade of natural spinosyns produced by Saccharopolyspora spinosa. The process begins with microbial fermentation, where a genetically modified strain is engineered to block a specific O methylation step, causing the organism to accumulate the precursor 5,6 dihydrospinosyn J. This fermentation product is then subjected to selective chemical modification, most notably 3′ O ethylation, to yield spinetoram J as one of the two active components of commercial spinetoram. The resulting semi synthetic molecule is purified to agrochemical grade and blended with spinetoram L to form the final insecticidal active ingredient.

Impact on climate of production and use

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C at pH 7 (mg l⁻¹)

29.0

as spinetoram

Moderate

Solubility - In organic solvents at 20 °C (mg l⁻¹)

250000

Methanol

250000

Acetone

250000

Xylene

61000

n-Heptane

Melting point (°C)

Boiling point (°C)

803.5

Degradation point (°C)

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

1.23 X 10⁰⁴

Calculated

Log P

4.09

High

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

Dissociation constant pKa) at 25 °C

Vapour pressure at 20 °C (mPa)

5.7 X 10^-02

as spinetoram

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

4.0 X 10^-03

as spinetoram

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Neutral soln.: 245nm=12200
Acidic soln.: 247nm=12400
Basic soln.: 247nm=12400

Surface tension (mN m⁻¹)

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

16.1

as spinetoram

Non-persistent

DT₅₀ (lab at 20 °C)

16.1

as spinetoram

Non-persistent

DT₅₀ (field)

2.8

as spinetoram

Non-persistent

DT₉₀ (lab at 20 °C)

87.0

as spinetoram

Moderately persistent

DT₉₀ (field)

31.1

as spinetoram

DT₅₀ modelling endpoint

Note

EU dossier for spinetoram Lab studies DT₅₀ range 5-86.9 days, DT₉₀ range 27.1-420.0 days, additional study 72881 days; Field studies XDE-175-J: DT₅₀ range 0.03-2.49 days, DT₉₀ 1.6-25.7, XDE-175-L: DT₅₀ range 0.07-2.0, DT₉₀ range 0.51-7.91 days; Manufacturer published data gives field studies DT₅₀ 3-5 days, lab studies DT₅₀ 13-21 days

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

0.4

as spinetoram

Fast

Note

DT₅₀ 0.3-0.5 days summer sunlight 40 Deg N

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Stable

as spinetoram

Stable

Note

Stable pH 5 to pH 9 at 25 °C

Water-sediment DT₅₀ (days)

273

as spinetoram

Slow

Water phase only DT₅₀ (days)

5.1

as spinetoram

Moderately fast

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

37.3

Non-mobile

K_oc (mL g⁻¹)

22836

Notes and range

EU dossier for spinetoram K_d range 12-61 mL g⁻¹, K_oc range 1470-5490, soils=10; Manufacturer published data K_oc = 1800-43873 mL g⁻¹

Freundlich

K_f (mL g⁻¹)

Slightly mobile

K_foc (mL g⁻¹)

2544

¹/_n

0.949

Notes and range

EU dossier for spinetoram K_f range 8.6-43.8 mL g⁻¹, K_foc range 1263-6257 mL g⁻¹, ¹/_n range 0.83-1.11, Soils=10

pH sensitivity

Known metabolites

None

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

Birds - Short term dietary LC₅₀ (mg kg⁻¹ bw d⁻¹)

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)

Soil micro-organisms

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

Seedling emergence ER₅₀ (g ha⁻¹)

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps)

Beneficial insects (Predatory mites)

Beneficial insects (Ground beetles)

Beneficial insects (Butterflies)

Contact

Notes

Oral

Notes

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹)

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)

Algae - Acute (growth rate, fresh; mg l⁻¹)

Algae - Chronic (growth rate, fresh; mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

Regulatory Threshold Levels (RTLs)

Note: These RTLs have been calculated using the regulatory approach used in the European Union and based on ecotoxocity values in the PPDB.

Species group

RTL

Notes

Mammals

No data

No data for acute and chronic mammals

Birds

No data

No data for acute and chronic birds

Soil organisms

No data

No data for acute and chronic earthworms

Terrestrial plants

No data

No data for non-target plants vegetative vigour and seedling emergence

Pollinators

No data

No data for contact and oral honeybees

Arthropods

No data

No data for parasitic wasps and predatory mites

Fish

No data

No data for temperate acute and chronic fish

Aquatic invertebrates

No data

No data for temperate acute and chronic aquatic invertebrates

Aquatic plants

No data

No data for free-floating plants, rooted plants, acute and chronic algae

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

Mammals - Short Term Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Long Term (Chronic) Oral NOAEL (mg kg⁻¹ bw d⁻¹)

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

> 5000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.0

Rat 4 hr

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.025

as spinetoram

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.1

as spinetoram

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.0065

as spinetoram

Dermal penetration studies (%)

5-11

concentration dependent

Dangerous Substances Directive 76/464

Exposure Routes

Public

Acceptable for proposed uses

Occupational

Acceptable for proposed uses

Mammalian dose elimination route and rate

85% eliminated via the faeces majority of which is lost in the first 24hrs

Health issues

Specific human health issues (hazard-based)

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

Potential for slow accumulation in the body
Possible thyroid toxicant
Weak sensitiser

Handling issues

Property

Value and interpretation

General

Not explosive or oxidising
Not expected to auto-ignite; Not highly flammable

CLP classification 2013

Health: H317, H361
Environment: H400, H410

WHO Classification

U (Unlikely to present an acute hazard)

UN Number

Waste disposal & packaging

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

spinetoram J

French

German

Danish

Italian

Spanish

espinetoram J

Greek

Polish

Swedish

Hungarian

Dutch

Norwegian

Record last updated:	24/02/2026
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242

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