Cinidon-ethyl (Ref: BAS 615H)

Cinidon-ethyl (Ref: BAS 615H)	Last updated: 24/10/2025
(Also known as: cinidon-ethyl)

SUMMARY

Cinidon-ethyl is a post-emergence herbicide. It has a low aqueous solubility, is relatively volatile with a low tendency to leach to groundwater. It is slightly mobile. It is not persistent in soil or water systems. Cinidon-ethyl has a low mammalian toxicity and is not expected to bioaccumulate. It is moderately toxic to earthworms but more toxic to aquatic organisms. It is relatively non- toxic to honeybees.

Hazard alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. These hazard alerts do not take account of usage patterns or exposure, thus do not represent risk.

Environmental fate	Ecotoxicity	Human health	Highly Hazardous Pesticide
Environmental fate Moderate alert: Drainflow: Slightly mobile; Potential for particle bound transport: Medium	Ecotoxicity Moderate alert: Fish chronic ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Daphnia chronic ecotoxicity: Moderate	Human health Moderate alert: Possible Carcinogen; Reproduction/development effects	Highly Hazardous Pesticide (HHP) Type II alert

GENERAL INFORMATION

Description

A herbicide for post-emergence control of annual broadleaved weeds

Example pests controlled

Nettles; Docks; Chickweed; Groundsel

Example applications

Cereals including wheat, rye, triticale

Efficacy & activity

GB regulatory status

GB COPR regulatory status

Not approved

Date COPR inclusion expires

Expired

GB LERAP status

No UK approval for use as a plant protection agent

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Not approved

Dossier rapporteur/co-rapporteur

Hungary/UK

Date EC 1107/2009 inclusion expires

Expired

EU Candidate for substitution (CfS)

Not applicable

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece

ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg

LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Chemical structure

Isomerism

Cinidon-ethyl exhibits geometrical isomerism, specifically existing in E- and Z-forms due to the configuration around its double bond.

Chemical formula

C₁₉H₁₇Cl₂NO₄

Canonical SMILES

CCOC(=O)C(=CC1=C(C=CC(=C1)N2C(=O)C3=C(C2=O)CCCC3)Cl)Cl

Isomeric SMILES

CCOC(=O)/C(=C/C1=C(C=CC(=C1)N2C(=O)C3=C(C2=O)CCCC3)Cl)/Cl

International Chemical Identifier key (InChIKey)

NNKKTZOEKDFTBU-YBEGLDIGSA-N

International Chemical Identifier (InChI)

InChI=1S/C19H17Cl2NO4/c1-2-26-19(25)16(21)10-11-9-12(7-8-15(11)20)22-17(23)13-5-3-4-6-14(13)18(22)24/h7-10H,2-6H2,1H3/b16-10-

2D structure diagram/image available?

Yes

General status

Pesticide type

Herbicide

Substance groups

Dicarboximide herbicide

Minimum active substance purity

940 g kg⁻¹

Known relevant impurities

EU dossier - None declared

Substance origin

Synthetic

Mode of action

Contact action, selective and acts by protox-inhibition

CAS RN

142891-20-1

EC number

604-318-6

CIPAC number

598

US EPA chemical code

Not listed

PubChem CID

5851439

CLP index number

616-107-00-6

Molecular mass

394.3

PIN (Preferred Identification Name)

ethyl (2Z)-2-chloro-3-[2-chloro-5-(1,3-dioxo-1,3,4,5,6,7-hexahydro-2H-isoindol-2-yl)phenyl]prop-2-enoate

IUPAC name

ethyl (Z)-2-chloro-3-[2-chloro-5-(cyclohex-1-ene-1,2-dicarboximido)phenyl]acrylate

CAS name

ethyl (2Z)-2-chloro-3-[2-chloro-5-(1,3,4,5,6,7-hexahydro-1,3-dioxo-2H-isoindol-2-yl)phenyl]-2-propenoate

Listed (✓) under

UK Poisons List Order 1972	Rotterdam Convention	Montreal Protocol
XNo The Poisons List Order 1972	XNo Rotterdam Convention	XNo Montreal Protocol
Stockholm Convention	OSPAR	EU Water Framework Directive
XNo Stockholm Convention	XNo OSPAR	XNo EU Water Framework Directive

Relevant Environmental Water Quality Standards

Forever chemical

Highly Hazardous Pesticide (HHP)

Type I

Type II

Yes [; ]

Other status information

Herbicide Resistance Class (HRAC MoA class)

Herbicide Resistance Class (WSSA MoA class)

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Physical state

White crystalline powder

Commercial

Property

Value

Availability status

Current

Introduction & key dates

1990s, first synthesised; 1999, key studies published; 2001, first European approvals; 2012, phased out EU

Example manufacturers & suppliers of products using this active now or historically

BASF
Nufarm

Example products using this active

Lotus
Bingo
Orbit
Solar

Formulation and application details

Usually supplied as an emulsifiable concentrate

Commercial production

Cinidon-ethyl is produced commercially through a multi-step synthesis involving aromatic substitution and esterification reactions. The process begins with the preparation of a substituted phthalimide intermediate, which is then coupled with a chlorinated phenylpropenoic acid derivative. This coupling forms the core structure of cinidon-ethyl. The final step involves esterification with ethanol to enhance solubility and formulation stability. The synthesis is carried out under controlled conditions to ensure high purity and yield.

Impact on climate of production and use

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C at pH 7 (mg l⁻¹)

0.057

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

213000

Acetone

8000

Methanol

84000

Toluene

2000

n-Heptane

Melting point (°C)

112.5

Boiling point (°C)

360

Degradation point (°C)

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

2.51 X 10⁰⁵

Calculated

Log P

5.4

High

Fat solubility of residues

Solubility

Data type

Density (g ml⁻¹)

1.4

Dissociation constant pKa) at 25 °C

Not applicable

No dissociation

Vapour pressure at 20 °C (mPa)

0.01

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

6.91 X 10^-02

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

290nm = 11000, 300nm = 5800

Surface tension (mN m⁻¹)

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

1.3

Non-persistent

DT₅₀ (lab at 20 °C)

1.3

Non-persistent

DT₅₀ (field)

DT₉₀ (lab at 20 °C)

Non-persistent

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

EU dossier Lab studies DT₅₀ range 0.6-1.9 days, DT₉₀ range 6-22 days

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

Note

Aqueous photolysis DT₅₀ (days) at pH 7

Value

2.3

Moderately fast

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

1.5

Non-persistent

Note

pH sensitive: DT₅₀ 5 days at pH 5, 54 mins at pH 9 all at 20 °C

Water-sediment DT₅₀ (days)

0.2

Fast

Water phase only DT₅₀ (days)

0.1

Fast

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

K_oc (mL g⁻¹)

Notes and range

Freundlich

K_f (mL g⁻¹)

87.7

Slightly mobile

K_foc (mL g⁻¹)

3262

¹/_n

Notes and range

EU dossier Soils=4

pH sensitivity

Adsorption decreases as pH increases

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

0.06

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

1.93 X 10^-04

Calculated

Note

Potential for particle bound transport index

Medium

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

2.5

Calculated using the Atkinson method. EU trigger for long-range transport is DT₅₀ in air <2 days.

Below the level of concern for long-range air transport

Bio-concentration factor

BCF (l kg⁻¹)

Whole fish

Low potential

CT₅₀ (days)

Not available

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

(Z)-2-chloro-3-(2-chloro-5-(1,3,dioxo-4,5,6,7-tertahydroisoindol-2-yl)phenyl)acrylic acid

Major fraction

0.600

(Z)-2-chloro-3-(2-chloro-5-(((2-hydroxycarbonyl)cyclohexen-1-yl)carbonylamino)phenyl)acrylic acid

Major fraction

0.460

2-(N-(3-((1Z)-2-carboxy-2-chlorovinyl)-4-chlorophenyl)carbamoy)--hydroxycyclohex-1-enecarboxylic acid

Major fraction

0.210

cinidon (free acid)

Major fraction

Known groundwater metabolites

None

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

cyclohexene-1,2-dicarboxylic acid

615M20

Water (a=Hydrolysis), (b=Photolysis)

a=0.599 @ pH7; b=0.794

ethyl (2Z)-3-(3-amino-6-chlorophenyl)-2-chloroprop-2-enoate

615M16

Water (a=Hydrolysis), (b=Photolysis)

a=0.249 @ pH7; b=0.143

(Z)-2-chloro-3-[2-chloro-5-(((2-hydroxycarbonyl)cyclohexen-1-yl)carbonylamino)phenyl]acrylic acid ethyl ester

615M07

Water (Hydrolysis)

0.261 @ pH7

cyclohexene-1,2-dicarboxylic anhydride

615M21

Water (Hydrolysis)

0.241 @ pH9

(2Z)-3-(3-amino-6-chlorophenyl)-2-chloroprop-2-enoic acid

615M10

Water (Hydrolysis)

0.349 @ pH9

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2200

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2000

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 5000 ppm

Colinus virginianus

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)

> 1000

Low

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: Field rate 28 Day

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

Seedling emergence ER₅₀ (g ha⁻¹)

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 200

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 200

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps)

0% Mortality at dose 50 g ha⁻¹

Aphidius rhopalosiphi

Beneficial insects (Predatory mites)

9.8% Mortality at dose 50 g ha⁻¹

Typhlodromus pyri corr

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

200

Oncorhynchus mykiss

Low

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

1.0

Oncorhynchus mykiss

Moderate

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

59.2

Daphnia magna

Moderate

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

0.11

Daphnia magna

Moderate

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹) (EbC50 (biomass))

0.174

Lemna gibba

Moderate

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)

Algae - Acute (growth rate, fresh; mg l⁻¹) (EbC50 (biomass))

0.015

Raphidocelis subcapitata

Moderate

Algae - Chronic (growth rate, fresh; mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

> 2200

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

> 2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

5.3

Rat

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.01

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

None allocated

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

Not applicable

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.02

Dermal penetration studies (%)

Dangerous Substances Directive 76/464

Exposure Routes

Public

Minimal risk of dietary exposure

Occupational

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

Mammalian dose elimination route and rate

Health issues

Specific human health issues (hazard-based)

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

No data found

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

No data found

General human health issues

CLP data - suspected carcingen

Handling issues

Property

Value and interpretation

General

Not explosive or oxidising
IMDG Transport Hazard Class 9
Not expected to auto-ignite; Not highly flammable

CLP classification 2013

Health: H317, H351
Environment: H400, H410

WHO Classification

Not listed (Not listed)

UN Number

UN3077

Waste disposal & packaging

Packaging Group III (minor danger)

Shelf-life, storage, stability and reactivity

TRANSLATIONS

Language

Name

English

cinidon-ethyl

French

cinidon-ethyl

German

Cinidon-ethyl

Danish

cinidon ethyl

Italian

cinidon etile

Spanish

cinidon etil

Greek

Polish

cinidon etylowy

Swedish

cinidonetyl

Hungarian

kinidon-etil

Dutch

Norwegian

Record last updated:	24/10/2025
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242