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Ipflufenoquin (Ref: NF-180)
Last updated: 14/03/2024
(Not known by any other names)

SUMMARY
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
High alert:
Persistent
Ecotoxicity
Moderate alert:
Fish acute ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Earthworms acute ecotoxicity: Moderate; Earthworms chronic ecotoxicity: Moderate
Human health
Low alert
GENERAL INFORMATION
Description
A fungicide that offers protection against a wide range of plant diseases
Example pests controlled
Grey mold; Scab, Rice blast
Example applications
Apples; Pears; Almonds
Efficacy & activity
Efficacy and crop safety has been evaluated in a number of countries including Australia and France
Availability status
Novel
Introduction & key dates
2022, first registered in USA
UK regulatory status
UK COPR regulatory status
Not approved
Date COPR inclusion expires
Not applicable
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Pending
Dossier rapporteur/co-rapporteur
Netherlands
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
Canada, Australia, USA
Chemical structure
Isomerism
None
Chemical formula
C₁₉H₁₆F₃NO₂
Canonical SMILES
CC1=C(C=C2C=CC(=C(C2=N1)F)F)OC3=C(C(=CC=C3)F)C(C)(C)O
Isomeric SMILES
Not applicable
International Chemical Identifier key (InChIKey)
DSXOWZNZGWXWMX-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C19H16F3NO2/c1-10-15(9-11-7-8-13(21)17(22)18(11)23-10)25-14-6-4-5-12(20)16(14)19(2,3)24/h4-9,24H,1-3H3
2D structure diagram/image available?
Yes
General status
Pesticide type
Fungicide
Substance groups
Quinoline fungicide
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Dihydroorotate dehydrogenase (DHODH) inhibitor
CAS RN
1314008-27-9
EC number
No data found
CIPAC number
1000
US EPA chemical code
-
PubChem CID
-
CLP index number
No data found
Molecular mass
347.33
PIN (Preferred Identification Name)
2-(2-[(7,8-difluoro-2-methylquinolin-3-yl)oxy]-6-fluorophenyl)propan-2-ol
IUPAC name
2-(2-[(7,8-difluoro-2-methyl-3-quinolyl)oxy]-6-fluorophenyl)propan-2-ol
CAS name
2-[(7,8-difluoro-2-methyl-3-quinolinyl)oxy]-6-fluoro-α,α-dimethylbenzenemethanol
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
Not applicable
Herbicide Resistance Class (WSSA MoA class)
Not applicable
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
52
Examples of recorded resistance
None identified
Physical state
Pale yellow crystalline solid
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • Nippon-Soda Co. Ltd
  • Nisso America
  • AgNova Technologies Pty Ltd
Example products using this active
  • MIGIWA Fungicide
  • Kinoprol 20 SC
Formulation and application details
Usually supplied as a liquid suspension concentrate
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
9.2
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
- - -
Melting point (°C)
114
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
165
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
-
Degradation point (°C)
- - -
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
- - -
Log P
- - -
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
1.3904
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
Dissociation constant pKa) at 25 °C
2.18
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
-
-
Vapour pressure at 20 °C (mPa)
7.76 X 10-03
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
2.93 X 10-04
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Non-volatile
Volatilisation as max % of applied dose lost
From plant surface
- - -
From soil surface
- - -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
Max at 234.5nm = 32990
p4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
-
Surface tension (mN m⁻¹)
- - -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
790
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Very persistent
DT₅₀ (lab at 20 °C)
790
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Very persistent
DT₅₀ (field)
226
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Persistent
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
-
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
-
DT₅₀ modelling endpoint
- - -
Note
Australian Dossier 2024: Lab studies DT₅₀ (normalised) range 428 to1903 days; Field studies DT₅₀ (measured) range 28 to 767 days.
Dissipation rate RL₅₀ (days) on plant matrix
Value
3.89 - -
Note
P4 at 25 °C
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
10.3
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Moderately fast
Note
8.7-12.0 days at 40°N
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Stable
Note
Stable at all relevant pH values
Water-sediment DT₅₀ (days)
533
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Stable
Water phase only DT₅₀ (days)
33
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Stable
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
- - -
Koc (mL g⁻¹)
-
Notes and range
-
Freundlich
Kf (mL g⁻¹)
-
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Slightly mobile
Kfoc (mL g⁻¹)
988
1/n
0.9
Notes and range
Australian Dossier 2024
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.37 Calculated Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
1.39 X 10-01 Calculated -
Note
-
Potential for particle bound transport index
Medium Calculated -
Potential for loss via drain flow
Slightly mobile Calculated -
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
- - -
Bio-concentration factor
BCF (l kg⁻¹)
73
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
(whole fish)
Low potential
CT₅₀ (days)
- -
Known metabolites

None

ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rat
Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
- - -
Birds - Acute LD₅₀ (mg kg⁻¹)
> 2000
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Low
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
- - -
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
> 500
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Eisenia andrei corr
Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
33
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Eisenia andrei as EC10 corr
Moderate
Soil micro-organisms
- - -
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Non-target plants
> 100
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
10 crop species
Vegetative vigour, ER25
as g ha⁻¹
-
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 107
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps) Mortality g ha⁻¹
> 300
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Aphidius rhopalosiphi
-
Beneficial insects (Predatory mites) Mortality g ha⁻¹
> 300
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Typhlodromus pyri
-
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
4.0
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Cyprinodon variegatus marine species
Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)
- - -
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
> 2.5
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Daphnia magna
Moderate
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
> 98.0
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
> 4.6
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Lemna gibba
Moderate
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
> 2.6
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Skeletonema costatum
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 2000
P5 P = Other non-EU, UK or US Governments and Regulators
5 = Verified data used for regulatory purposes
Rat
Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
- - -
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.048
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Rat SF=100 Australia
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
1.2
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
Rat SF=100 Australia
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
-
Occupational
-
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
Elimination is usually complete within 96 hrs. Biliary excretion is extensive (>50%)
P4 P = Other non-EU, UK or US Governments and Regulators
4 = Verified data
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database)
0 = No data
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
XNo, known not to cause a problem
No data found
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
No data found
?Possibly, status not identified
XNo, known not to cause a problem
Eye irritant Phototoxicant  
XNo, known not to cause a problem
No data found  
General human health issues
No information available
Handling issues
Property
Value and interpretation
General
Not highly flammable
Not explosive or oxidising
CLP classification 2013
-
WHO Classification
Not listed (Not listed)
UN Number
-
Waste disposal & packaging
-
Shelf-life, storage, stability and reactivity
Stable for at least 2 years under standard ambient conditions
TRANSLATIONS
Language
Name
English
ipflufenoquin
French
ipflufénoquine
German
-
Danish
-
Italian
-
Spanish
-
Greek
-
Polish
-
Swedish
-
Hungarian
-
Dutch
-
Norwegian
-

Record last updated: 14/03/2024
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242