Niclosamide-olamine
Last updated: 10/01/2024
(Also known as: niclosamide ethanolamine salt)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
 
A largely obsolete antiparasitic control agent for humans and animals
Used for treating tape worm infections. Also used to control aquatic pests (Aquatic snails; Sea lamprey)
Horses; Ruminants; Cats; Dogs; Sheep; Poultry; Aquatic Situations
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Not approved
Not applicable
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Not applicable
Not applicable
No
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
None
C₁₅H₁₅Cl₂N₃O₅
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XYCDHXSQODHSLG-UHFFFAOYSA-N
InChI=1S/C13H8Cl2N2O4.C2H7NO/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15;3-1-2-4/h1-6,18H,(H,16,19);4H,1-3H2
Yes
Cambridge Crystallographic Data Centre diagrams
Fungicide, Molluscicide, Nematicide, Veterinary substance, Teniacide
Chloronitrophenol molluscidie
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Synthetic
Respiratory & stomach action. Acts by uncoupling oxidative phosphorylation in the tapeworm
1420-04-8
No data found
599
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No data found
388.203
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide—2-aminoethan-1-ol (1/1)
2′,5-dichloro-4′-nitrosalicylanilide - 2-aminoethanol (1:1)
5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide compound with 2-aminoethanol (1:1)
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Not applicable
Not applicable
Not applicable
Not applicable
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Available in a variety of formulations for oral administration as a veterinary treatment and as an emulsifiable concentrate for aquatic use.
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91.0
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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155
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
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1.26 X 1004
Calculated
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4.1
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
High
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Soil adsorption and mobility
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Cannot be calculated
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None
Terrestrial ecotoxicology
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HUMAN HEALTH AND PROTECTION
High (class III)
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May be absorbed through the skin or mucous membranes
EU MRL pesticide database 
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Some metabolism, metabolites and unchanged parent lost mainly via the faeces
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
May cause gastrointestinal problems, anorexia, irritability & alopecia Salts may cause occular irritation Harmful if swallowed
Avoid formation of dust IMDG Transport Hazard Class 9
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U (Unlikely to present an acute hazard)
UN3077
Packaging Group III (minor danger)
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niclosamide-olamine
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Record last updated:
10/01/2024
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242