Quizalofop-P-tefuryl (Ref: UBI C4874 )

Quizalofop-P-tefuryl (Ref: UBI C4874 )	Last updated: 13/11/2025
(Also known as: pantera)

SUMMARY

Hazard alerts

The following Pesticide Hazard Tricolour (PHT) alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement. The alerts for Highly Hazardous Pesticides (HHPs) are based on applying the FAO/WHO (Type 1) and the PAN (Type II) criteria to PPDB data. Further details on the HHP indicators are given in the tables below. Neither the PHT nor the HHP hazard alerts take account of usage patterns or exposure, thus they do not represent risk.

PHT: Environmental fate	PHT: Ecotoxicity	PHT: Human health	Highly Hazardous Pesticide
Environmental fate Moderate alert: Drainflow: Slightly mobile	Ecotoxicity High alert: Daphnia acute ecotoxicity: High	Human health High alert: Reproduction/development effects	Highly Hazardous Pesticide (HHP) Type II alert

GENERAL INFORMATION

Description

A herbicide for the control of annual and perennial grass and broadleaved weeds in a variety of crops

Example pests controlled

Bentgrass; Volunteer cereals; Perennial ryegrass; Italian ryegrass; Couch

Example applications

Sugarbeet; Fodder beet; Winter and spring OSR; Potatoes; Combining peas; Field beans; Other pulses; Linseed; Sunflowers

Efficacy & activity

GB regulatory status

GB COPR regulatory status

Approved

Date COPR inclusion expires

30/11/2028

GB LERAP status

None

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

Croatia/Austria

Date EC 1107/2009 inclusion expires

28/02/2027

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
	✓	✓		✓	✓		✓	✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
			✓	✓	✓		✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓			✓		✓	✓		✓

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Australia; Morocco

Chemical structure

Isomerism

A chiral molecule. Quizalofop-P-tefuryl is the more biologically active enantimer of the racemate quizalofop-tefuryl.

Chemical formula

C₂₂H₂₁ClN₂O₅

Canonical SMILES

CC(C(=O)OCC1CCCO1)OC2=CC=C(C=C2)OC3=CN=C4C=C(C=CC4=N3)Cl

Isomeric SMILES

No data

International Chemical Identifier key (InChIKey)

BBKDWPHJZANJGB-IKJXHCRLSA-N

International Chemical Identifier (InChI)

InChI=1S/C22H21ClN2O5/c1-14(22(26)28-13-18-3-2-10-27-18)29-16-5-7-17(8-6-16)30-21-12-24-20-11-15(23)4-9-19(20)25-21/h4-9,11-12,14,18H,2-3,10,13H2,1H3

2D structure diagram/image available?

Yes

General status

Pesticide type

Herbicide

Substance groups

Aryloxyphenoxypropionate herbicide

Minimum active substance purity

954 g kg⁻¹

Known relevant impurities

EU 2025 dossier - None declared

Substance origin

Synthetic

Mode of action

Systemic, absorbed through leaves and translocated. Acetyl CoA carboxylase inhibitor (ACCase) - distrupts fatty acid biosynthesis and lipid formation.

CAS RN

200509-41-7

Alternative/old CAS RN

119738-06-6

EC number

414-200-4

CIPAC number

641.266

US EPA chemical code

PubChem CID

86175

Molecular mass

428.89

PIN (Preferred Identification Name)

[(2E)-oxolan-2-yl]methyl (2R)-2-{4-[(6-chloroquinoxalin-2-yl)oxy]phenoxy}propanoate

IUPAC name

(RS)-tetrahydrofurfuryl (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionate

CAS name

(tetrahydro-2-furanyl)methyl (2R)-2-(4-((6-chloro-2-quinoxalinyl)oxy)phenoxy)propanoate

Global Governance status: Listed (✓) under

UK Poisons List Order 1972	Rotterdam Convention	Montreal Protocol
XNo The Poisons List Order 1972	XNo Rotterdam Convention	XNo Montreal Protocol
Stockholm Convention	OSPAR	EU Water Framework Directive
XNo Stockholm Convention	XNo OSPAR	XNo EU Water Framework Directive

Relevant Environmental Water Quality Standards

Forever chemical

Highly Hazardous Pesticide (HHP)

Type I

Type II

Yes [; ; ]

Other status information

Marine pollutant

Herbicide Resistance Class (HRAC MoA class)

Herbicide Resistance Class (WSSA MoA class)

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Echinochloa crus-galli, Sorghum sudanese

Physical state

White solid when pure, technical material is an orange waxy solid

Related substances & organisms

quizalofop

quizalofop-ethyl

quizalofop-P-ethyl

Commercial

Property

Value

Availability status

Current

Introduction & key dates

1989, introduced

Example manufacturers & suppliers of products using this active now or historically

Certis
Crompton Specialities
Nissan

Example products using this active

Panarex
Pantera

Formulation and application details

Often supplied as an emulsifiable concentrate that is used as a foliar spray via a tractor mounted sprayer

Commercial production

Quizalofop-P-tefuryl is commercially produced through a chiral transesterification process where the ethyl ester intermediate (R)-2-[4-(6-chloroquinoxalin-2-yloxy)phenoxy]propionate, synthesised via etherification of 2,6-dichloroquinoxaline with hydroquinone followed by stereoselective alkylation with an (S)-2-halopropionate, is reacted with tetrahydrofurfuryl alcohol in the presence of dibutyltin oxide catalyst, yielding the active compound.

Impact on climate of production and use

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C at pH 7 (mg l⁻¹)

0.708

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

652000

Toluene

12000

Hexane

64000

Methanol

221000

Acetone

Melting point (°C)

58.3

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

219

Flashpoint (°C)

132

Octanol-water partition coefficient at pH 7, 20 °C

2.09 X 10⁰⁴

Calculated

Log P

4.32

High

Fat solubility of residues

Solubility

Soluble

Data type

Regulatory data based on LogP

Density (g ml⁻¹)

1.28

Dissociation constant pKa) at 25 °C

No dissociation

Vapour pressure at 20 °C (mPa)

1.6 X 10^-02

at 25 °C

Low volatility

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

0.0097

at 25 °C

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

From soil surface

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

Neutral solution 238nm = 15171, 334nm = 5782
Acidic solution 238 nm = 15169, 334nm = 5815
Basic solution 238 nm= 15081, 334nm = 5733

Surface tension (mN m⁻¹)

at 20 °C 98.9%

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Not readily biodegradable

Soil degradation (days) (aerobic)

DT₅₀ (typical)

0.3

Non-persistent

DT₅₀ (lab at 20 °C)

0.3

Non-persistent

DT₅₀ (field)

0.82

Non-persistent

DT₉₀ (lab at 20 °C)

1.41

Non-persistent

DT₉₀ (field)

6.26

DT₅₀ modelling endpoint

Note

EU 2025 dossier lab studies DT₅₀ (normalised) range 0.1-2.4 days, DT₉₀ (measured) range 0.23-5.0 days, Soils=11; field studies DT₅₀ (measured) range 0.03-1.2 days, DT₉₀ (measured) range 0.6-4.1 days, Soils=5

Dissipation rate RL₅₀ (days) on plant matrix

Value

0.6

Note

Mung bean, whole plant, n=1

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

3.1

Note

Published literature RL₅₀ range 0.7-5.6 days, 2 field grown crops, various matrices, n=2

Aqueous photolysis DT₅₀ (days) at pH 7

Value

0.6

Fast

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

17.8

Non-persistent

Note

pH sensitive: DT₅₀ 7.6 days at pH 5, 0.3 days at pH 9, all at 22-25 °C

Water-sediment DT₅₀ (days)

0.08

Fast

Water phase only DT₅₀ (days)

0.15

Fast

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

Slightly mobile

K_oc (mL g⁻¹)

2000

Notes and range

EU 2025 dossier - substance degrades rapidly in aerobic soils to the acid.

Freundlich

K_f (mL g⁻¹)

Slightly mobile

K_foc (mL g⁻¹)

2000

¹/_n

Notes and range

Due to the rapid hydrolysis of quizalofop-P-tefuryl adsborption studies not possible. K_oc value expected to be similar to quizalofop-P-ethyl (1024 – 3078 mL g⁻¹)

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

-0.06

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

9.30 X 10^-05

Calculated

Note

Potential for particle bound transport index

Low

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

2.7

Calculated using the Atkinson method. Assumed 1.5E+06 OH/cm³, 12 hr. EU trigger for long-range transport is DT₅₀ in air <2 days.

Below the level of concern for long-range air transport

Bio-concentration factor

BCF (l kg⁻¹)

340

Whole fish

Threshold for concern

CT₅₀ (days)

0.94

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

quizalofop (Ref: CGA 287422)

Major fraction

1.00

hydroxy quizalofop (Ref: CGA 294972)

Major fraction

0.326

dihydroxy quinoxaline (Ref: CGA 294970)

Major fraction

0.181

hydroxy-quinoxaline

Minor fraction

0.058

tetrahydrofurfuryl alcohol

Major fraction

0.595

tetrahydrofuroic acid

Minor fraction

0.093

quizalofop phenol

Minor fraction

Known groundwater metabolites

Metabolite

EC SANCO/221/2000 relevancy

ADI (mg kg⁻¹ bodyweight day⁻¹)

WHO drinking water guidance value (μg L⁻¹ day⁻¹)

quizalofop (Ref: CGA 287422)

Not relevant

0.01

hydroxy quizalofop (Ref: CGA 294972)

Not relevant

dihydroxy quinoxaline (Ref: CGA 294970)

Not relevant

tetrahydrofurfuryl alcohol

Not relevant

tetrahydrofuroic acid

Not relevant

hydroxy-quinoxaline

Not relevant

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

quizalofop (Ref: CGA 287422)

Surface water; Sediment; Rat; Plant

hydroxy quizalofop (Ref: CGA 294972)

Surface water; Sediment; Rat; Plant

dihydroxy quinoxaline (Ref: CGA 294970)

Surface water; Sediment; Rat; Plant

quizalofop phenol

Surface water; Sediment; Rat; Plant

tetrahydrofurfuryl alcohol

Surface water; Sediment

tetrahydrofuroic acid

Surface water; Sediment

hydroxyquinoxaline

Surface water; Sediment

quizalofop-pentanoic acid

Animal

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

1012

Rat

Moderate

Mammals - Short term dietary NOEL

(mg kg⁻¹)

> 125

Rat

Moderate

(ppm diet)

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

16.9

Rat Reproductive NOAEL

Moderate

Birds - Acute LD₅₀ (mg kg⁻¹)

> 2150

Colinus virginianus

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 258.6 mg kg bw⁻¹ day⁻¹

Anas platyrhynchos

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

68.7

Anas platyrhynchos NOEC

Moderate

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹ dw soil)

> 500

Eisenia foetida corr

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹ dw soil)

Soil micro-organisms

Nitrogen transformation: No significant adverse effect

Dose: 0.667 mg kg⁻¹ soil 28 Day

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

6.2

Seedling emergence ER₅₀ (g ha⁻¹)

236.4

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 40

Apis mellifera

Moderate

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

16.8

Apis mellifera

Moderate

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings) as % Mortality at 100 g ha⁻¹

83.9

Chrysoperla carnea

Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹, Std lab test

< 100

Aphidius rhopalosiphi

Moderate

Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹, Std lab test

< 100

Typhlodromus pyri

Moderate

Beneficial insects (Ground beetles) as % Mortality at 100 g ha⁻¹

Poecilus cupreus

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

0.23

Lepomis macrochirus

Moderate

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

> 0.008

Daphnia magna

High

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹) (EC₅₀, Static with renewal)

4.394

Lemna gibba

Moderate

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹) (NOEC, Static with renewal)

0.87

Lemna gibba

Moderate

Algae - Acute (growth rate, fresh; mg l⁻¹) (72 hr ErC₅₀, Static)

> 1.452

Navicula pelliculosa

Moderate

Algae - Chronic (growth rate, fresh; mg l⁻¹)

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

1012

Rat

Moderate

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

> 2000

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 3.9

Rat 4 hr (nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.013

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.1

Rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.01

Rat SF=100

Dermal penetration studies (%)

3-26

concentration dependent

Dangerous Substances Directive 76/464

Exposure Routes

Public

Moderate risk to bystanders

Occupational

Operators should use PPE/PPC
Low risk to other workers for proposed conditions of use

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

0.1

EU Dir 89/778/EC limit

Mammalian dose elimination route and rate

Urinary excretion was 35-48% in females and 12-41% in males within 7 days after dosage

Health issues

Specific human health issues (hazard-based)

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

No data found

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

Respiratory tract irritant

Skin irritant

Skin sensitiser

No data found

Eye irritant

Phototoxicant

General human health issues

Moderately toxic
Liver toxicant
CLP data - suspected carcinogen

Handling issues

Property

Value and interpretation

General

Not explosive or oxidising
IMDG Transport Hazard Class 9
Not expected to auto-ignite at temps<400 DegC; Not highly flammable

CLP classification 2013

Health: H302, H351, H361fd, H373
Environment: H400, H410

WHO Classification

II (Moderately hazardous)

UN Number

UN3077

Waste disposal & packaging

Packaging Group III (minor danger)

Shelf-life, storage, stability and reactivity

Stability may be affected by light

TRANSLATIONS

Language

Name

English

quizalofop-P-tefuryl

French

quizalofop-P-tefuryl

German

Quizalofop-P-tefuryl

Danish

quizalofop-P-tefuryl

Italian

quizalofop-P-tefuryl

Spanish

quizalofop-P-teruril

Greek

Polish

kwizalofop-P-tefurylowy

Swedish

Hungarian

quinzalofop-P-tefuril

Dutch

Norwegian

Record last updated:	13/11/2025
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242