Cinmethylin (Ref: BAS 684 H) |
![]() Last updated: 14/01/2023 |
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(Also known as: WL 95481; cinch; SD 95481) |
SUMMARY |
Cinmethylin is a selective, pre-emergence herbicide used mainly for rice and cereal crops. It is moderately soluble in water, is quite volatile and, based on its chemical properties, it is non-mobile and would not be expected to leach to groundwater. It may be persistent in both soil and aquatic systems. It is not susceptible to hydrolysis. It is not acutely toxic to mammals but it is an eye and skin irritant. It shows a moderate level of toxicity to birds, fish and daphnia. |
Data alerts |
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate | Ecotoxicity | Human health |
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A pre-emergence herbicide used to control annual grasses and broad -eaved weeds | |
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Barnyard grass; Velvetleaf; Crabgrass; Pigweed; Annual ryegrass; Black grass; Annual meadow grass and annual dicots | |
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Rice; Soybeans; Cereals including winter wheat, winter barley; Winter oilseed rape | |
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Efficacy established via field trials | |
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Current | |
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1989 |
UK regulatory status |
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Pending - approval anticipated | ||
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Not applicable | ||
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EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Additional information |
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Australia |
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Chemical structure |
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A chiral molecule with three stereocenters. The technical material is an isomeric mixture. | |
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C₁₈H₂₆O₂ | |
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CC1=CC=CC=C1COC2CC3(CCC2(O3)C)C(C)C | |
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No data | |
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QMTNOLKHSWIQBE-UHFFFAOYSA-N | |
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InChI=1S/C18H26O2/c1-13(2)18-10-9-17(4,20-18)16(11-18)19-12-15-8-6-5-7-14(15)3/h5-8,13,16H,9-12H2,1-4H3/t16-,17+,18-/m1/s1 | |
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Yes |
General status |
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Herbicide, Other substance | |
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Biocide | |
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Cineole compound; Unclassified herbicide | |
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>940 g kg⁻¹ | |
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UK HSE Dossier: BAS 4539586 (1SR,2RS,4RS)-1-methyl-4-(pro-pan-2-yl)-7--oxa-bicyclo2.2.1-heptan-2-ol: 4.0 g kg⁻¹; Toluene: 0.5 g kg⁻¹ | |
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Synthetic | |
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Selective, systemic, absorbed by roots and translocated. Disrupts the meristemic development in shoots and roots of susceptible weeds. | |
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87818-31-3 | |
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402-410-9 | |
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None allocated | |
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128837 | |
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91745 | |
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603-093-00-1 | |
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274.40 | |
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rac-(1R,2S,4S)-1-methyl-2-[(2-methylphenyl)methoxy]-4-(propan-2-yl)-7-oxabicyclo[2.2.1]heptane | |
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rac-(1R,2S,4S)-1-methyl-4-(1-methylethyl)-2-((2-methylphenyl)methoxy)-7-oxabicyclo[2.2.1]heptane | |
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rel-(1R,2S,4S)-1-methyl-4-(1-methylethyl)-2-((2-methylphenyl)methoxy)-7-oxabicyclo[2.2.1]heptane | |
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Risk of spray drift; Registered Under REACH | |
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- | |
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Q | |
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30 | |
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Not applicable | |
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Not applicable | |
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- | |
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Dark orange liquid, colourless in pure form |
Formulations |
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Usually supplied as an emusifiable concentrate or as granules for use as a foliar spray |
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58 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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Miscible | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Acetone5 = Verified data used for regulatory purposes |
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Miscible | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Ethyl acetate5 = Verified data used for regulatory purposes |
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Miscible | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK n-Heptane5 = Verified data used for regulatory purposes |
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Miscible | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Methanol5 = Verified data used for regulatory purposes |
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Decomposes before melting | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK solidifies at -56 °C5 = Verified data used for regulatory purposes |
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330 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
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None observed <400 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
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- | - | - | ||||||||
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3.16 X 1004 | Calculated | - | |||||||
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4.5 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
High | ||||||||
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1.014 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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n/a | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
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No dissociation | |||||||||||
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8.1 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Moderately volatile | ||||||||
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3.2 X 10-02 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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pH 6.8: 209nm=8671.6, 262nm=269.0 pH 6.0: 196nm=22072.9, 208nm=8774.2, 263nm=327.9 pH 1.8: 9nm=12125.9, 208nm=8768;3, 263nm=327.9 pH 12.1: 215nm: 6017.6, 263nm=312.7 |
AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
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50.3 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 20 °C 99%5 = Verified data used for regulatory purposes |
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Degradation |
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Not readily biodegradable | ||||||||||
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93.6 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Moderately persistent | |||||||
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93.6 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Moderately persistent | ||||||||
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22.4 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Non-persistent | ||||||||
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231.9 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Persistent | ||||||||
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111.5 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
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11.1 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK normalised5 = Verified data used for regulatory purposes |
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UK HSE dossier 2020: Lab studies DT₅₀ (measured) range 18.5-93.6 days; DT₉₀ (measured)range 63.5-541.4 days, Soils= 4; Field studies DT₅₀ (measured) range 2.5-207.6 days, DT₉₀ (measured) range 18.2-207.6 days, Soils=11; Literature values DT₅₀ range 23-75 days; slower in paddy fields | ||||||||||
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41.8 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Stable | |||||||
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Stable | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Stable | |||||||
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Stable pH 3 to pH 11 at 25 °C. | ||||||||||
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39.2 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Moderately fast | ||||||||
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7.0 | AG4 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 4 = Verified data |
Moderately fast |
Soil adsorption and mobility |
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- | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
Non-mobile | |||||||
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6850 | ||||||||||
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Other data source: 300 mL g⁻¹ (US3) | ||||||||||
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4.6 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Moderately mobile | |||||||
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317.9 | ||||||||||
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0.97 | ||||||||||
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UK HSE Dossier 2020: kf range 1.9-13.5 mL g⁻¹, Kfoc range 266.5-510.1 mL g⁻¹, 1/n range 0.94-1.00, Soils=5 | ||||||||||
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None |
Fate indices |
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2.02 | Calculated | Transition state | ||||||||||||||||||||||||||
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6.88 X 10-02 | Calculated | - | |||||||||||||||||||||||||
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Medium | Calculated | - | ||||||||||||||||||||||||||
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Non-mobile | Calculated | - | ||||||||||||||||||||||||||
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677 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
Threshold for concern | |||||||||||||||||||||||||
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1.12 | - |
Known metabolites |
None
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Terrestrial ecotoxicology |
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> 2000 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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- | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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30 | - | |||||||||
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> 3776 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Colinus virginianus5 = Verified data used for regulatory purposes |
Low | ||||||||
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- | - | - | ||||||||
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99.1 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Colinus virginianus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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- | - | - | ||||||||
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43.63 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Eisenia andrei5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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67.0 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Folsomia foetida5 = Verified data used for regulatory purposes |
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31.3 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Ryegrass5 = Verified data used for regulatory purposes ER₅₀ vegetative vigour as g ha⁻¹ |
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- | - | - | |||||||||
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> 200 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Apis mellifera5 = Verified data used for regulatory purposes |
Low | |||||||
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> 200 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Apis mellifera5 = Verified data used for regulatory purposes |
Low | ||||||||
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143.2 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Apis mellifera5 = Verified data used for regulatory purposes |
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> 272 | AG3 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Bombus terrestris as BAS684 02 H3 = Unverified data of known source |
Low | |||||||
Data based on preparation | |||||||||||
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112 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Aphidius rhopalosiphii5 = Verified data used for regulatory purposes |
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629.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Typhlodromus pyri5 = Verified data used for regulatory purposes |
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Aquatic ecotoxicology |
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> 5.75 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Cyprinus carpio5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.59 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Pimephales promelas5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 10.68 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.29 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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- | - | - | ||||||||
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0.089 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Lemna gibba5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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23.04 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Pseudokirchneriella subcapitata5 = Verified data used for regulatory purposes |
Low | ||||||||
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- | - | - |
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General |
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High (class III) | - | - | ||||||||
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> 2000 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Rat5 = Verified data used for regulatory purposes |
Low | ||||||||
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5000 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Rat5 = Verified data used for regulatory purposes |
- | ||||||||
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> 5.3 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Rat 4 hr (nose only)5 = Verified data used for regulatory purposes |
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0.08 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Dog SF=1005 = Verified data used for regulatory purposes |
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0.3 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Rat SF=1005 = Verified data used for regulatory purposes |
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0.21 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Rat SF=1005 = Verified data used for regulatory purposes |
- | ||||||||
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0.06 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK Dog SF=1005 = Verified data used for regulatory purposes |
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0.4-22.0 | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK concentration dependent5 = Verified data used for regulatory purposes |
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No unacceptable risks identified for proposed pattern of use | |||||||||
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No unacceptable risks identified for proposed pattern of use | ||||||||||
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Rapid excretion via both the urine and faeces | AG5 AG = Chemicals Regulation Division, Health and Safety Executive (HSE), UK 5 = Verified data used for regulatory purposes |
- |
Health issues |
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Gastrointestinal or liver toxicant May damage nasal cavity |
Handling issues |
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Not explosive or oxidising Not expected to autoignite; Not highly flammable |
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Health: H332 Environment: H410 |
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III (Slightly hazardous) | |||
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cinmethylin | ||
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cinméthyline | ||
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cynmetylina | ||
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Record last updated: | 14/01/2023 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |