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cadusafos (Ref: FMC 67825)
** ebufos ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Cadufos is an organophosphate insecticide and nematicide that is not approved for use in the EU. It has a moderate aquatic solubility, is very volatile and moderately mobile. It can be persistent in both soil and water systems. Cadufos is highly toxic to mammals and there is also some concern regarding its tendency to bioaccumulate. It is highly toxic to birds and earthworms, and moderately toxic to honeybees and most aquatic organisms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for cadusafos

Description: A organophosphate insecticide used to control various nematodes and soil-borne insects

Example pests controlled: Nematodes; Wireworms; Cutworms

Example applications: Bananas; Citrus; Maize; Potatoes; Sugarcane

Efficacy & activity: -

Availability status: Current

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Greece
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with 2 chiral centres
Chemical formula C10H23O2PS2
Canonical SMILES CCC(C)SP(=O)(OCC)SC(C)CC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) KXRPCFINVWWFHQ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H23O2PS2/c1-6-9(4)14-13(11,12-8-3)15-10(5)7-2/h9-10H,6-8H2,1-5H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Nematicide
Substance group Organophosphate
Minimum active substance purity 900 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Broad spectrum activity with contact and stomach action. Cholinesterase inhibitor.
CAS RN 95465-99-9
EC number -
CIPAC number 682
US EPA chemical code 128864
PubChem CID 91752
Molecular mass (g mol-1) 270.39
PIN (Preferred Identification Name) S,S-di(butan-2-yl) O-ethyl phosphorodithioate
IUPAC name S,S-di-sec-butyl O-ethyl phosphorodithioate
CAS name O-ethyl S,S-bis(1-methylpropyl) phosphorodithioate
Other status information Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Culex pipiens quinquefasciatus
Physical state Clear liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically -
Example products using this active
  • Ruby SC
  • Apache
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often supplied as a capsule suspension which is mixed with water and used as a spray but also available in other formulations.


ENVIRONMENTAL FATE

for cadusafos

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 245 A5 - @ 25 DegC Moderate
Solubility - In organic solvents at 20oC (mg l-1) 125000 A5 - Heptane -
250000 A5 - Methanol -
Miscible A5 - Xylene -
Miscible A5 - Acetone -
Melting point (oC) None observed A3 -
Boiling point (oC) 115 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.08 X 1003 Calculated -
Log P 3.85 A5 High
Bulk density (g ml-1)/Specific gravity 1.05 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 119.6 A5 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 0.132 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.88 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.62 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 224nm = 884, no significant absorbance >= 290nm A5 -
Surface tension (mN m-1) 42.2 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 38 A5 Moderately persistent
DT50 (lab at 20oC) 56.7 A5 Moderately persistent
DT50 (field) 39 A5 Moderately persistent
DT90 (lab at 20oC) 188 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 50.9-51.6 days, DT90 range 169.1-206.8 days, n=5 at 20 DegC, field studies DT50 range 12-59 days, European soils
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 26.2 R4 -
Note Published literature RL50 range 23.0-29.0 days, 2 field crops, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 174 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable at pH 5 to pH9, 25 degC.
Water-sediment DT50 (days) 215 A5 Slow
Water phase only DT50 (days) 37 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 3.8 A5 Moderately mobile
Kfoc 227
1/n 0.99
Notes and range EU dossier Kf range 2-6 mL/g, Kfoc range 144-351 mL/g, 1/n range 0.97-1.00, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
methyl-2-butyl sulfone Soil   0.08   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
carbon dioxide - Soil (Aerobic) - -
(2RS,3RS)-3,4-dihydroxybutane-2-sulfonic acid - Rat (Urinary, hydroxylated form) - -
(2RS,3RS)-2-hydroxy-3-(methylsulfonyl)butanic acid)
Note: Transient metabolite
- Plant - -
(2RS,3RS)-3-(methylsulfonyl)butan-2-ol - Plant; Rat - -
S,S-(2RS)-dibutan-2-yl hydrogen phosphorodothioate
(Ref: FMC 78115)
Note: Possible cholinesterase inhibition activity
- Plant; Water - -
S-[(2RS)-butan-2-yl]dihydrogen phosphorothioate
(Ref: FMC 78123)
Note: Possible cholinesterase inhibition activity
- Plant; Water - -
(RS)-[S-[(2RS)-butan-2-yl]S-ethyl hydrogen phosphorodithioate]
(Ref: FMC 78135)
- Water - -


ECOTOXICOLOGY

for cadusafos

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 220 A5 Whole fish Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 30.1 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 0.067 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 16.1 A5 Colinus virginianus High
Birds - Short term dietary (LC50/LD50) 10.8 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.13 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.0052 A3 Oncorhynchus mykiss, 95 day High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.00075 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00023 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.032 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 4.3 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 1.08 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) 2.07 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 7.2 A4 Eisenia foetida High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 1.8 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 3.75 48 hour
A5 Aphidius rhopalosiphi
-
% Effect 100 Mortality
Dose: 5000 kg ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 44.4 7 day
A5 Typhlodromus pyri
-
% Effect 100 Mortality
Dose: 5000 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 50 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 0.00005 A5 Aquatic invertebrates -
NOEAEC mg l-1 0.00125 A4 Aquatic community, recovery from advserse direct effects -


HUMAN HEALTH AND PROTECTION

for cadusafos

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 30.1 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 10.7 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.026 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0004 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.003 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.0007 A2 Rat, 90 day, SF=100 -
Dermal penetration studies (%) 100 A3 default -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational No unacceptable risk if PPE/PPC is used
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=0.45 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R26/27
T - Toxic: R25
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S13, S36/37, S45, S63
WHO Classification Ib - Highly hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number 3018
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group II (medium danger)


TRANSLATIONS

for cadusafos

Language Name
English cadusafos
French cadusafos
German Cadusafos
Danish cadusafos
Italian cadusafos
Spanish cadusafos
Greek -
Slovenian kadusafos
Polish kadusafos
Swedish -
Hungarian -
Dutch -

Record last updated: Tuesday 07 August 2018
Contact: aeru@herts.ac.uk