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Monocrotophos (Ref: ENT 27129)
Last updated: 04/03/2020
(Also known as: azadrin; corophos; OMS 834)

GENERAL INFORMATION
Description
Used to control sucking and chewing pests typically on cotton, citrus and many other crops
Example pests controlled
Aphids; Common mites; Ticks; Spiders; Caterpillars
Example applications
Cotton; Palms; Ornamental conifers; Ornamental shrubs and flowers; Peanuts; Sugarcane; Citrus; Olives
Efficacy & activity
-
Availability status
Unknown
Introduction & key dates
-
UK regulatory status
UK approval status
Not approved
EC Regulation 1107/2009 (repealing 91/414)
EC Directive 91/414 Status
Not approved
Dossier rapporteur/co-rapporteur
Italy
Date inclusion expires
Expired
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
Yes
Approved for use (✓) or known to be used (#) in the following EU-27 Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
                 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
                 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
                 
Also used in
Also used in
-
Chemical structure
Isomerism
-
Chemical formula
C₇H₁₄NO₅P
Canonical SMILES
C/C(=C\C(=O)NC)/OP(=O)(OC)OC
Isomeric SMILES
No data
International Chemical Identifier key (InChIKey)
KRTSDMXIXPKRQR-AATRIKPKSA-N
International Chemical Identifier (InChI)
InChI=1S/C7H14NO5P/c1-6(5-7(9)8-2)13-14(10,11-3)12-4/h5H,1-4H3,(H,8,9)/b6-5+
2D structure diagram/image available?
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name Relationship Link
monocrotophos -
General status
Pesticide type
Insecticide, Acaricide
Substance group
Organophosphate
Minimum active substance purity
-
Known relevant impurities
-
Substance origin
Synthetic
Mode of action
Broad spectrum, systemic with stomach and contact action. Acetylcholinesterase (AChE) inhibitor.
CAS RN
6923-22-4
EC number
230-042-7
CIPAC number
287
US EPA chemical code
058903
PubChem CID
5371562
Molecular mass
223.16
PIN (Preferred Identification Name)
dimethyl (2E)-4-(methylamino)-4-oxobut-2-en-2-yl phosphate
IUPAC name
dimethyl (E)-1-methyl-2-(methylcarbamoyl)vinyl phosphate
CAS name
dimethyl (1E)-1-methyl-3-(methylamino)-3-oxo-1-propenyl phosphate
Other status information
PIC Annex III; Marine Pollutant; Rotterdam Convention (Class Ib)
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Classification (HRAC)
Not applicable
Herbicide Resistance Classification (WSSA)
Not applicable
Insecticide Resistance Classification (IRAC)
1B
Fungicide Resistance Classification (FRAC)
Not applicable
Examples of recorded resistance
Bemisia tabaci, Boophilus microplus, Cacopsylla pyri, Earias vittella, Lygus hesperus, Spodoptera littoralis, many others
Physical state
Colourless crystals when pure reddish-brown as technical substance
Related substances & organisms
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • Nuvacron
  • Crisodrin
  • Monophos
  • Monodrin
  • Phoskill
Example products using this active
  • BASF
  • AgroCare
  • King Tech Corp
  • United Phosphorus
UK LERAP status
No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details
Available as a water soluble concentrate and ULV formulation
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
818000
E3 E = Manufacturers safety data sheets
3 = Unverified data of known source
High
Solubility - In organic solvents at 20 °C (mg l⁻¹)
700000
Q2 Q = Miscellaneous internet resources
2 = Unverified data of unknown source
Acetone
-
1000000
Q2 Q = Miscellaneous internet resources
2 = Unverified data of unknown source
Methanol
-
10000
E3 E = Manufacturers safety data sheets
3 = Unverified data of known source
Toluene
-
292000
E3 E = Manufacturers safety data sheets
3 = Unverified data of known source
Ethanol
-
Melting point (°C)
54
G3 G = Extension Toxicology network database EXTOXNET (click here )
3 = Unverified data of known source
-
Boiling point (°C)
- - -
Degradation point (°C)
- - -
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
6.03 X 10-01 Calculated -
Log P
-0.22
G3 G = Extension Toxicology network database EXTOXNET (click here )
3 = Unverified data of known source
Low
Bulk density (g ml⁻¹)
1.16
Q2 Q = Miscellaneous internet resources
2 = Unverified data of unknown source
-
Dissociation constant pKa) at 25 °C
- - -
-
Vapour pressure at 20 °C
0.29
G3 G = Extension Toxicology network database EXTOXNET (click here )
3 = Unverified data of known source
Low volatility
Henry's law constant at 25 °C
- - -
GUS leaching potential index
4.02 Calculated High leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
8.78 X 10-01 Calculated -
Note
-
Potential for particle bound transport index
Low Calculated -
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
- - -
Surface tension (mN m⁻¹)
- - -
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
7
G3 G = Extension Toxicology network database EXTOXNET (click here )
3 = Unverified data of known source
Non-persistent
DT₅₀ (lab at 20 °C)
- - -
DT₅₀ (field)
30
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Moderately persistent
DT₉₀ (lab at 20 °C)
- - -
DT₉₀ (field)
- - -
DT₅₀ modelling endpoint
- - -
Note
Literature values for soil DT₅₀ range 1-35 days
Dissipation rate RL₅₀ on plant matrix
Value
5.0
R4 R = Peer reviewed scientific publications
4 = Verified data
-
Note
Published literature RL₅₀ range 2.4-7.8 days, 2 field grown crops, various matrices, n=2
Dissipation rate RL₅₀ on and in plant matrix
Value
3.7
R4 R = Peer reviewed scientific publications
4 = Verified data
-
Note
Published literature RL₅₀ range 1.3-14.5 days, 10 field grown crops, various matrices, n=11
Aqueous photolysis DT₅₀ (days) at pH 7
Value
26
P3 P = Other governments and regulators
3 = Unverified data of known source
Slow
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
134
P3 P = Other governments and regulators
3 = Unverified data of known source
Persistent
Note
-
Water-sediment DT₅₀ (days)
- - -
Water phase only DT₅₀ (days)
- - -
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
P3 P = Other governments and regulators
3 = Unverified data of known source
Mobile
Koc
19
Notes and range
Literature values for Koc range 0.9-30.8 mL g⁻¹
Freundlich
Kf
- - -
Kfoc
-
1/n
-
Notes and range
-
pH sensitivity
-
ECOTOXICOLOGY
Property
Value
Source; quality score; and other information
Interpretation
Bio-concentration factor
BCF (l kg⁻¹)
Low risk
Q3 Q = Miscellaneous internet resources
3 = Unverified data of known source
Based on LogP < 3
Low risk
CT₅₀ (days)
- -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
14
F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
4 = Verified data
Rat
High
Mammals - Short term dietary NOEL
(mg kg⁻¹)
- - -
(ppm diet)
- -
Birds - Acute LD₅₀ (mg kg⁻¹)
> 0.94
G3 G = Extension Toxicology network database EXTOXNET (click here )
3 = Unverified data of known source
Colinus virginianus
High
Birds - Short term dietary (LC₅₀/LD₅₀)
- - -
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
> 7.0
G3 G = Extension Toxicology network database EXTOXNET (click here )
3 = Unverified data of known source
Oncorhynchus mykiss
Moderate
Fish - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
0.023
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Daphnia magna
High
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
- - -
Non-target plants
- - -
- - -
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
- - -
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
0.02
R4 R = Peer reviewed scientific publications
4 = Verified data
High
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other pollinators (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
1.1
R4 R = Peer reviewed scientific publications
4 = Verified data
Megachile rotundata
Moderate
Mode of exposure
Contact
Other pollinators (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
35
R4 R = Peer reviewed scientific publications
4 = Verified data
Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
- - -
Other soil macro-organisms
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
- - -
Other arthropod (1)
LR₅₀ g ha⁻¹
- - -
% Effect
- - -
Other arthropod (2)
LR₅₀ g ha⁻¹
- - -
% Effect
- - -
Soil micro-organisms
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
14
F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
4 = Verified data
Rat
High
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
157
J4 J = Pesticide Action Network database (click here )
4 = Verified data
Rat
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
- - -
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.0006
F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
4 = Verified data
JMPR 1995
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
0.002
F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment )
4 = Verified data
JMPR 1995
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
- - -
Dermal penetration studies (%)
- - -
Dangerous Substances Directive 76/464
List I; List II - -
Exposure Routes
Public
Minimal risk from food residues
Exposure by general public unlikely
Occupational
Full protective clothing required including respirator to minimise operator and worker exposure
May be absorbed through skin
European MRLs
EU MRL pesticide database 
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database)
3 = Negative
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E1 E = Unspecified genotoxicity type (miscellaneous data source)
1 = Positive
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
?Possibly, status not identified
Yes, known to cause a problem
Yes, known to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
XNo, known not to cause a problem
Yes, known to cause a problem
No data found
Eye irritant Phototoxicant  
Yes, known to cause a problem
No data found  
General human health issues
Highly toxic orally
Handling issues
Property
Value and interpretation
General
Corrosive
IMDG Transport Code is 6.1
CLP classification 2013
Health: H300, H311; H330; H340
Environment: H400, H410
EC Risk Classification
T+ : Very toxic: R26/28, R68
T - Toxic: R24
N - Dangerous for the environment: R50, R53
EC Safety Classification
S1/2, S36/37, S45, S60, S61
WHO Classification
Ib (Highly hazardous / Highly hazardous)
UN Number
2783
Waste disposal & packaging
-
TRANSLATIONS
Language
Name
English
monocrotophos
French
monocrotophos
German
Monocrotophos
Danish
-
Italian
-
Spanish
monocrotofos
Greek
-
Polish
monokrotofos
Swedish
-
Hungarian
-
Dutch
-

Record last updated: 04/03/2020
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242