(Also known as: toxaphene; polychlorocamphene; chlorocamphene; toxafeen; octachlorocamphene)
SUMMARY
Camphechlor is an obsolete insecticide and acaricide. It has a low aqueous solubility, is quite volatile and moderately mobile. Based on its chemical properties, it has a high risk of leaching to groundwater. It is not expected to be persistent in soil but may be persistent in water systems. Camphechlor is highly toxic to mammals and is likely to bioaccumulate. It is highly toxic to birds and most aquatic organisms.
Data alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: Drainflow: Moderately mobile; Potential for particle bound transport: Medium
Ecotoxicity High alert: Birds acute ecotoxicity: High; Fish acute ecotoxicity: High; Fish chronic ecotoxicity: High; Daphnia acute ecotoxicity: High; Bees acute contact ecotoxicity: High
Human health High alert: Mammals acute toxicity: High; Carcinogen; Reproduction/development effects
GENERAL INFORMATION
Description
An obsolete insecticide that was often used in conjunction with other active substances to control a wide range on insects on crops and livestock
Example pests controlled
Lygus bugs; Aphids; Spidermites; Ticks; Fleas; Mange mites; Lice; Scab mites; Grasshoppers; Armyworms; Cutworms
Example applications
Cotton; Ornamentals; Pineapples; Corn and small grains; Vegetables; Oilseeds; Livestock
Efficacy & activity
-
Availability status
Considered obsolete but may be available in some countries; Banned in many countries
Introduction & key dates
1947, first developed
UK regulatory status
UK COPR regulatory status
Not approved
Date COPR inclusion expires
Expired
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Not applicable
Date EC 1107/2009 inclusion expires
Expired
EU Candidate for substitution (CfS)
-
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009; by Mutual Recognition of Authorisation; and/or national regulations in the following EEA countries
A non-systemic contact and stomach insecticide. It acts on the neurons, causing an imbalance in sodium and potassium ions, similar to that of the cyclodiene insecticides.
CAS RN
8001-35-2
EC number
232-283-3
CIPAC number
23
US EPA chemical code
080501
PubChem CID
58167
CLP index number
602-044-00-1
Molecular mass
413.96
PIN (Preferred Identification Name)
-
IUPAC name
reaction mixture of chlorinated camphenes containing 67–69% chlorine
CAS name
2,2,5-endo,6-exo,8,8,9,10-Octachlorobornane
Other status information
Chemical subject to PIC regulations; OSPAR soc; POP - regulated by Stockholm Convention; Severe Marine Pollutant; Rotterdam Convention (Class O); PAN Bad Actor
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Classification (HRAC)
Not applicable
Herbicide Resistance Classification (WSSA)
Not applicable
Insecticide Resistance Classification (IRAC)
Not known
Fungicide Resistance Classification (FRAC)
Not applicable
Examples of recorded resistance
-
Physical state
Yellow to amber waxy solid
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
Hercules
BCF
Example products using this active
Agrones Hepta
Altox
Attac
Toxaphene
Phenacide
Phenatox
Toxakil
101 Brand Cabbage Dust
Formulation and application details
Usually formulated as a wettable power, dust or emulsifiable concentrate
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
-
Data type
Observed in metabolism and farm animal feeding studies
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
6.08 X 10-01
V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source
Moderately volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
-
-
-
Surface tension (mN m⁻¹)
-
-
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
365
L1 L = Pesticide manuals and hard copy reference books / other sources 1 = Estimated data with little or no verification
Very persistent
DT₅₀ (lab at 20 °C)
-
-
-
DT₅₀ (field)
9
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Non-persistent
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
DT₅₀ modelling endpoint
-
-
-
Note
Literature sources highly variable: DT₅₀ 2 months and 14 years; US sources: 9 days (DW3, US3); Field DT₅₀ 9 to 500 days (R3)
Dissipation rate RL₅₀ on plant matrix
Value
3.6
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Note
Published literature RL₅₀ range 1.6-5.0 days, 4 field crops, various matrices, n=4
Dissipation rate RL₅₀ on and in plant matrix
Value
12.6
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Note
Published literature RL₅₀ range 2.3-25.2 days, 4 field crops, various matrices, n=7
Aqueous photolysis DT₅₀ (days) at pH 7
Value
-
-
-
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Stable
Note
-
Water-sediment DT₅₀ (days)
-
-
-
Water phase only DT₅₀ (days)
-
-
-
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source
Moderately mobile
Koc
295
Notes and range
Literature range for log Koc = 2.47-5.00; Other sources: Koc 100000 mL g⁻¹ (US2)
Freundlich
Kf
-
-
-
Kfoc
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
1.46
Calculated
Low leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
1.86 X 10-02
Calculated
-
Note
-
Potential for particle bound transport index
Medium
Calculated
-
Potential for loss via drain flow
Moderately mobile
Calculated
-
Bio-concentration factor
BCF (l kg⁻¹)
76000
R4 R = Peer reviewed scientific publications 4 = Verified data
V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source
Rat
High
Mammals - Short term dietary NOEL
(mg kg⁻¹)
-
-
-
(ppm diet)
-
-
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
-
-
-
Birds - Acute LD₅₀ (mg kg⁻¹)
> 15
V3 V = ChemID Online Databases; Chemspider; PubChem. (ChemID ) 3 = Unverified data of known source
Anas platyrhynchos
High
Birds - Short term dietary (LC₅₀/LD₅₀)
-
-
-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
-
-
-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
-
-
-
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
-
-
-
Soil micro-organisms
-
-
-
Collembola
Acute LC₅₀ (mg kg⁻¹)
-
-
-
Chronic NOEC (mg kg⁻¹)
-
-
-
Non-target plants
-
-
-
-
-
-
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
0.144
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Apis mellifera
High
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 19.1
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Apis mellifera
Moderate
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
-
-
-
Chronic
-
-
-
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
-
-
-
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
-
-
-
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
-
-
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
-
-
-
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
0.216
R4 R = Peer reviewed scientific publications 4 = Verified data
Megachile rotundata
High
Mode of exposure
Contact
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
0.0023
R4 R = Peer reviewed scientific publications 4 = Verified data
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
Absorbed by the intact skin and from the gastrointestinal tract
MRLs
European
EU MRL pesticide database
Great Britain
GB MRL Register
Notes
-
Drinking Water Standards
-
-
-
Drinking Water MAC (μg l⁻¹)
-
-
-
Mammalian dose elimination route and rate
-
-
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
✓Yes, known to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
?Possibly, status not identified
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
?Possibly, status not identified
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
?Possibly, status not identified
No data found
General human health issues
IARC group 2B carcinogen Ingestion may be fatal May cause convulsions Potential kidney toxicant May cause allergic bronchopneumonia Endocrine issues - Increase of estrogen-sensitive cells proliferation
Handling issues
Property
Value and interpretation
General
Corrosive Not compatible with strongly alkaline pesticides
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Environmental fate
Ecotoxicity
