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chromafenozide (Ref: ANS 118)
** CM-001 ** CAL 97I1 18 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Chromafenozide is an insecticide awaiting EU approval for use. It has a very low aqueous solubility and is volatile. It is persistent in soil systems and may also be persistent in aquatic systems under certain conditions. It has a low mammalian toxicity and no significant health effects have been identified. It is moderately toxic to aquatic life but has a low toxicity to honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chromafenozide

Description: A novel insecticide used for control of various Lepidopteran species on top fruit and other crops

Example pests controlled: Rice borer; Leaf roller; Skipper; Caterpillars; Cutworms; Armyworms; Cotton bollworm

Example applications: Fruit including apples, pears, strawberries, cherries; Rice; Cabbage; Lettuce; Tea; Sugarbeet; Ornamentals; Cotton

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1999, first registered Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Hungary
Date inclusion expires 31/03/2025
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C24H30N2O3
Canonical SMILES CC1=CC(=CC(=C1)C(=O)N(C(C)(C)C)NC(=O)C2=C(C3=C(C=C2)OCCC3)C)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) HPNSNYBUADCFDR-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C24H30N2O3/c1-15-12-16(2)14-18(13-15)23(28)26(24(4,5)6)25-22(27)20-9-10-21-19(17(20)3)8-7-11-29-21/h9-10,12-14H,7-8,11H2,1-6H3,(H,25,27)/f/h25H
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Diacylhydrazine
Minimum active substance purity 935 g/kg
Known relevant impurities EU dossier - metabolite M-010
Substance origin Synthetic
Mode of action Ingestion, forces an incomplete and lethal moult. Ecdysone agonist. A moulting hormone agonist.
CAS RN 143807-66-3
EC number -
CIPAC number 775
US EPA chemical code -
PubChem CID 10157484
Molecular mass (g mol-1) 394.51
PIN (Preferred Identification Name) N'-tert-butyl-N'-(3,5-dimethylbenzoyl)-5-methyl-3,4-dihydro-2H-1-benzopyran-6-carbohydrazide
IUPAC name 2'-tert-butyl-5-methyl-2'-(3,5-xyloyl)chromane-6-carbohydrazide
CAS name 3,4-dihydro-5-methyl-2H-1-benzopyran-6-carboxylic acid 2-(3,5-dimethylbenzoyl)-2-(1,1-dimethylethyl)hydrazide
Other status information Possible groundwater contaminant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 18A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance None recorded
Physical state White crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Nippon
  • Sankyo Agro Co.
Example products using this active
  • Cyclone
  • Kanpai
  • Killat
  • Matric
  • Phares
  • Podex
  • CM-001 5%SC
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available as suspension concentrates, emulsifiable concentrates and dustable powders.


ENVIRONMENTAL FATE

for chromafenozide

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.80 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 320 A5 - Toluene -
173000 A5 - Ethanol -
186000 A5 - Acetone -
50600 A5 - Ethyl acetate -
Melting point (oC) 186.4 A5 -
Boiling point (oC) 205 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.01 X 1002 Calculated -
Log P 2.7 A5 Moderate
Bulk density (g ml-1)/Specific gravity 1.173 A5 -
Dissociation constant (pKa) at 25oC 13.24 A5 -
Note:
Vapour pressure at 20oC (mPa) 0.0087 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.973 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.96 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.06 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 248.8nm=10964, 290nm=851 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 132 A5 Persistent
DT50 (lab at 20oC) 132 A5 Persistent
DT50 (field) 105.8 A5 Persistent
DT90 (lab at 20oC) 485.5 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 103.6-172.8 days, DT90 range 367.2-603.8days; Field studies DT50 range 62.6-148.9 days; Literature studies DT50 range from 44-113 days for upland soils and 22-136 days for paddy fields
Dissipation rate RL50 on plant matrix Value 3.5 R3 -
Note Tomato fruit, n=1
Dissipation rate RL50 on and in plant matrix Value 3.8 R3 -
Note Strawberry fruit, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 26 A5 Slow
Note DT50 @ pH5=7 days; @ pH9= 24 days
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable at all environmentally relevant pHs
Water-sediment DT50 (days) 600 A4 - Stable
Water phase only DT50 (days) 81 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 1.67 A5 Moderately mobile
Koc 226
Notes and range EU dossier Kd range 1.594-1.755, Koc range 224-228, soils=2 mL/g
Freundlich Kf 8.88 A5 Moderately mobile
Kfoc 346.8
1/n 0.935
Notes and range EU dossier kf range 2.84-14.48 mL/g, Kfoc range 231-472 mL/g, 1/n range 0.92-0.96, soils=4
pH sensitivity None

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N-tert-butyl-N-(3,5-dimethylbenzoyl)-4-hydroxy-5-methyl-6-chromancarbohydrazide This metabolite may cause environmental pollution, click here for further information Soil   0.139   Major fraction; relevant


ECOTOXICOLOGY

for chromafenozide

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk Q3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Coturnix japonica Low
Birds - Short term dietary (LC50/LD50) > 5620 ppm A5 -
Fish - Acute 96 hour LC50 (mg l-1) > 106 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 516.7 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.84 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.075 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.94 A5 Desmodesmus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 4.76 L3 Selenastrum capricornutum Low
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 133.2 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida corr Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) > 24.5 A5 Eisenia foetida corr Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmless L3 Predatory mites -
Other arthropod (2) LR50 g ha-1 - - -
% Effect Harmless L3 Beneficial wasps -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 150 g ha-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chromafenozide

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.68 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.27 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.26 A5 Dog, SF=100 -
Dermal penetration studies (%) 2.0-63.0 A5 Concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Low risk for proposed uses
Occupational Low risk for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E0

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible mild skin sensitiser
Possible liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Fight fires using carbon dioxide, dry chemicals or foam
Not oxidising or explosive
CLP classification 2013 Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R51/53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for chromafenozide

Language Name
English chromafenozide
French -
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish chromafenozyd
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 03 July 2019
Contact: aeru@herts.ac.uk