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ipconazole (Ref: KNF 317)
** ipoconazole ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for ipconazole

Description: Used to control a range of soil and seed borne seed diseases in a wide range of crops including root and leafy vegetables, cereals and rice

Example pests controlled: Various fungal pathogens including Zygomycetes, Ascomycetes, Basidiomycetes and Deuteromycetes

Example applications: Root vegetables including beet, carrot, parsnip and radish; Leafy vegetables including celery, fennel, lettuce, spinach and Swiss chard; Brassicas including broccoli, cabbage and kale; Rice; Cereal grains, Cotton; Sunflower

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1994, Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires 31/08/2024
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Ipconazole is a chiral molecule with 3 stereocenters and 4 diastereoisomers, however the commercial material is a mixture of just two (cis-,cis- and cis-, trans) in the ratio 9 :1.
Chemical formula C18H24ClN3O
Canonical SMILES CC(C)C1CCC(C1(CN2C=NC=N2)O)CC3=CC=C(C=C3)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) QTYCMDBMOLSEAM-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H24ClN3O/c1-13(2)17-8-5-15(9-14-3-6-16(19)7-4-14)18(17,23)10-22-12-20-11-21-22/h3-4,6-7,11-13,15,17,23H,5,8-10H2,1-2H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 955 g/kg
Known relevant impurities EU dossier - ipconazole cc 875-930g/kg; ipconazole ct 65-95g/kg
Substance origin Synthetic
Mode of action Systemic, broad-spectrun, inhibits sterol synthesis in fungi.
CAS RN 125225-28-7
EC number -
CIPAC number 789
US EPA chemical code 125628
PubChem CID 86211
Molecular mass (g mol-1) 333.9
PIN (Preferred Identification Name) (1E,2E,5E)-2-[(4-chlorophenyl)methyl]-5-(propan-2-yl)-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentan-1-ol
IUPAC name (1RS,2SR,5RS;1RS,2SR,5SR)-2-(4-chlorobenzyl)-5-isopropyl-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
CAS name 2-[(4-chlorophenyl)methyl]-5-(1-methylethyl)-1-(1H-1,2,4-triazol-1-ylmethyl)cyclopentanol
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state Colourless crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Chemtura Europe
  • Kureha Corp
Example products using this active
  • Crusoe
  • Vortex
  • Rancona
UK LERAP status None (may vary with mixtures)
Formulation and application details Usually available as a microemulsion but also available as emulsifiable concentrates and suspension concentrates. Often used as a seed dressing.


ENVIRONMENTAL FATE

for ipconazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 9.34 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 570000 A5 - Acetone -
425000 A5 - 1,2-Dichloroethane -
428000 A5 - Ethyl acetate -
679000 A5 - Methanol -
Melting point (oC) 86 A5 -
Boiling point (oC) 400 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1004 Calculated -
Log P 4.3 A5 High
Bulk density (g ml-1)/Specific gravity 1.2 F3 -
Dissociation constant (pKa) at 25oC -5.43 A5 -
Note:
Vapour pressure at 20oC (mPa) 0.003 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.0 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.43 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.77 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral: 276nm=315
Acidic: 276nm=304
Basic: 276nm=312
A5 -
Surface tension (mN m-1) 56.5 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 50 L3 Moderately persistent
DT50 (lab at 20oC) 213 A5 Persistent
DT50 (field) 131 A5 Persistent
DT90 (lab at 20oC) 709 A5 -
DT90 (field) 390 A5 -
DT50 modelling endpoint - - -
Note EU dossier Lab studies DT50 range 170-294 days, DT90 range 564-977 days, Field studies DT50 range 66-228 days, DT90 range 219-757 days; Other sources: DT50 range 330 - 1386 days anaerobic, 136 to 210 days in aerobic soils & 89 to 121 days in paddy fields (F4); Other literature values DT50 range 45-54 days for upland soils and 76-80 days submerged soils (F4)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 495 F4 Stable
Note pH sensitive: pH5 = 330 days, pH7 = 495 days, pH9 = 257 days, all at 25 C
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 64 F3 - (natural sunlight) Moderately persistent
Note No degradation in the dark
Water-sediment DT50 (days) 344 A5 Slow
Water phase only DT50 (days) 2.4 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 67 A5 Slightly mobile
Kfoc 2431
1/n 0.81
Notes and range Kf range 5.2-108 mL/g, Kfoc range 1724-3124 mL/g, 1/n range 0.78-0.86, Soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
1,2,4-triazole (Ref: CGA 71019) This metabolite may cause environmental pollution, click here for further information Soil   0.237   Relevant, Major fraction

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- triazole alanine Plants - -
(Ref: KNF-317-M-21) triazole acetic acid Plants - -


ECOTOXICOLOGY

for ipconazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 350 F4 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 888 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 962 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) > 300 mg kg-1 BW/day A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 1.5 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) > 0.76 F3 Oncorhynchus mykiss, LOAEC Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 1.7 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.13 F4 Daphnia magna, LOAEC Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 3.25 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.62 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 597 A5 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 17.4 7-day
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 35.1 48 hours
A5 Aphidius rhopalosphophi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.88mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for ipconazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 888 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 3.53 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.015 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.015 A5 Rat, SF=200 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.015 A5 Rat, SF=200 -
Dermal penetration studies (%) 5% A5 Undiluted & co-applied with water -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Low for proposed uses
Occupational Calculated risks for seed treatment handlers are low
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A2; B0; C3; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible stomach toxicant
May cause eye damage
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H302, H361d, H373
Environment: H410
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R63
Xn - Harmful: R22
Xi - Irritant: R48
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for ipconazole

Language Name
English ipconazole
French -
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish ipkonazol
Swedish -
Hungarian -
Dutch -

Record last updated: Tuesday 25 June 2019
Contact: aeru@herts.ac.uk