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spinetoram (Ref: XDE 175)
** X574175 ** DE-175 ** GF-1587 ** GF-1640 ** spinotoram J ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for spinetoram

Description: A mixture of two natural fermentation-derived components with activity against a wide range of common insect pests

Example pests controlled: Apple moth; Grapevine moth; Codling moth; Oriental fruit moth; Western flower thrip; Pear & cherry slug;

Example applications: Fruit including grapes, apples, pears, apricots, cherries, plums, peaches

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2007, first registered USA

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires 30/06/2024
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA (pending)

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Spinetoram technical material is a mixture of XDE-175-J and XDE-175-L in the approximate ratio 3:1 but these substances are not isomers. XDE-175-J contains an extra methyl group. However both substances are complex molecules with multiple chiral centers.
Chemical formula C42H69NO10 / C43H69NO10
Canonical SMILES CCC1CCCC(C(C(=O)C2=CC3C(C2CC(=O)O1)CCC4C3CC(C4)OC5C(C(C(C(O5)C)OC)OCC)OC)C)OC6CCC(C(O6)C)N(C)C
Isomeric SMILES CC[C@H]1CCC[C@@H]([C@H](C(=O)C2=C[C@@H]3[C@H]([C@@H]2CC(=O)O1)CC[C@H]4[C@H]3C[C@@H](C4)O[C@H]5[C@@H]([C@@H]([C@H]([C@@H](O5)C)OC)OCC)OC)C)O[C@H]6CC[C@@H]([C@H](O6)C)N(C)C
International Chemical Identifier key (InChIKey) GOENIMGKWNZVDA-RWGFPKGXSA-N
International Chemical Identifier (InChI) InChI=1S/C42H69NO10/c1-10-27-13-12-14-35(53-37-18-17-34(43(6)7)24(4)49-37)23(3)38(45)33-21-31-29(32(33)22-36(44)51-27)16-15-26-19-28(20-30(26)31)52-42-41(47-9)40(48-11-2)39(46-8)25(5)50-42/h21,23-32,34-35,37,39-42H,10-20,22H2,1-9H3/t23-,24-,25+,26-,27+,28-,29-,30-,31-,32+,34+,35+,37+,39+,40-,41-,42+/m1/s1
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Spinosym
Minimum active substance purity 830 g/Kg
Known relevant impurities EU dossier - none declared
Substance origin Synthetic
Mode of action Acts through a novel site in the nicotinic receptor. Shows high residual, contact and ingestion activity
CAS RN 935545-74-7
Alternative/old CAS RN 187166-40-1 [J] / 187166-15-0 [L]
EC number -
CIPAC number 802
US EPA chemical code 110008 / 110009
PubChem CID 53297414
Molecular mass (g mol-1) 754.0 (mean)
PIN (Preferred Identification Name) Mixture of 50-90% (2R,3aR,5aR,5bS,9S,13S,14R,16aS,16bR)-2-(6-deoxy-3-O-ethyl-2,4-di-O-methyl-?-L-mannopyranosyloxy)-13-[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione
IUPAC name Mixture of 50-90% (2R,3aR,5aR,5bS,9S,13S,14R,16aS,16bR)-2-(6-deoxy-3-O-ethyl-2,4-di-O-methyl-?-L-mannopyranosyloxy)-13-[(2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methylpyran-2-yloxy]-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione
CAS name Mixture of 50-90% (2R,3aR,5aR,5bS,9S,13S,14R,16aS,16bR)-2-((6-deoxy-3-O-ethyl-2,4-di-O-methyl-?-L-mannopyranosyl)oxy)-13-(((2R,5S,6R)-5-(dimethylamino)tetrahydro-6-methyl-2H-pyran-2-yl)oxy)-9-ethyl-2,3,3a,4,5,5a,5b,6,9,10,11,12,13,14,16a,16b-hexadecahydro-14-methyl-1H-as-indaceno(3,2-d)oxacyclododecin-7,15-dione
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 5
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Off-white solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
Example products using this active
  • Delegate
  • Radiant
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


ENVIRONMENTAL FATE

for spinetoram

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 29.0 A4 - (component mean) Low
Solubility - In organic solvents at 20oC (mg l-1) 250000 A5 - Methanol -
250000 A5 - Acetone -
250000 A5 - Xylene -
61000 A5 - n-Heptane -
Melting point (oC) 107.1 A4 - 143.4 / 70.8 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 293 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.58 X 1004 Calculated -
Log P 4.2 A5 - 4.09 / 4.49 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 7.7 A5 -
Note: 7.86 / 7.59 Weak acid
Vapour pressure at 20oC (mPa) 5.7 X 10-02 A4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.0 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.72 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.22 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 DE-175-J [Neutral soln.: 245nm=12200
Acidic soln.: 247nm=12400
Basic soln.: 247nm=12400; XDE-175-L [Neutral soln.: 243nm=11100
Acidic soln.: 203nm=9800, 245nm=11400
Basic soln.: 244nm=11200
A5 -
Surface tension (mN m-1) 54.0 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 16.1 A5 Non-persistent
DT50 (lab at 20oC) 16.1 A5 Non-persistent
DT50 (field) 2.8 A5 Non-persistent
DT90 (lab at 20oC) 87.0 A4 -
DT90 (field) 31.1 A5 -
DT50 modelling endpoint - - -
Note EU dossier Lab studies DT50 range 5-86.9 days, DT90 range 27.1-420.0 days, additional study 72881 days; Field studies XDE-175-J: DT50 range 0.03-2.49 days, DT90 1.6-25.7, XDE-175-L: DT50 range 0.07-2.0, DT90 range 0.51-7.91 days; Manufacturer published data gives field studies DT50 3-5 days, lab studies DT50 13-21 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 2.62 R3 -
Note Tomato fruit, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 0.4 A5 Fast
Note DT50 0.3-0.5 days summer sunlight 40 Deg N
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9 at 25 degC
Water-sediment DT50 (days) 273 A5 Slow
Water phase only DT50 (days) 5.1 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 37.3 E4 Non-mobile
Koc 22836
Notes and range EU dossier Kd range 12-61 mL/g, Koc range 1470-5490, soils=10; Manufacturer published data Koc = 1800-43873 mL/g
Freundlich Kf 32 A5 Slightly mobile
Kfoc 2544
1/n 0.949
Notes and range EU dossier Kf range 8.6-43.8 mL/g, Kfoc range 1263-6257 mL/g, 1/n range 0.83-1.11, Soils=10
pH sensitivity None

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N-demethyl-spinetoram-J This metabolite may cause environmental pollution, click here for further information Soil   0.697   Major fraction; Relevant
N-demethyl-N-nitroso-spinetoram-J This metabolite may cause environmental pollution, click here for further information Soil   0.196   Major fraction; Relevant
N-demethyl-spinetoram-L This metabolite may cause environmental pollution, click here for further information Soil   0.438   Major fraction; Relevant
N-demethyl-N-nitroso-spinetoram-L This metabolite may cause environmental pollution, click here for further information Soil   0.136   Major fraction; Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- N-succinyl-spinetoram-J Soil 0.089 -
- N-succinyl-spinetoram-L Soil 0.163 -
- cysteine-XDE-175--J Rat - -
- cysteine-XDE-175-spinetoram-L Rat - -
- GSH-hydroxy-XDE-175-J Rat - -
- cysteine-hydroxy-XDE-175-J Rat - -
- GSH-N-demethyl-175-J Rat - -
- GSH-N-demethyl-175-J Rat - -
- N-formyl-175-J Plants - -
- N-formyl-175-L Plants - -
- 2-O-demethyl-175-J Sediment; Animals - -
- 2-O-demethyl-175-L Sediment; Animals - -
- 3-O-deethyl-175-J Plants; Rats; Animals - -
- 3-O-deethyl-175-L Plants; Rats; Animals - -
- GSH-3-O-deethyl-175-J Rat - -
- cysteine-3-O-deethyl-175-J Rat - -
- cysteine-3-O-deethyl-175-L Rat - -
- 4-O-demethyl-175-J Sediment; Hens - -
- 4-O-demethyl-175-L Hens - -
- C9-pseudoaglycone-175-J Plants - -
- C17-pseudoaglycone-175-J Plants - -
- C17-pseudoaglycone-175-L Plants - -
- 13,14-beta-dihydro-C17-pseudoaglycone-175-L Water (photolysis) - -
- sulfate-aglycone-175-J Rat - -
- GSH-hydroxy-C9-pseudoaglycone-175-J Rat - -
- N-acetyl-cysteine-C9-ketospseudoaglycone-175-J Rat - -
- glucuronamide-C9-pseudoaglycone-175-L Rat - -


ECOTOXICOLOGY

for spinetoram

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 114 A5 Threshold for concern
CT50 (days) 4.6 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Anas platyrhynchos, 32day -
Fish - Acute 96 hour LC50 (mg l-1) 2.69 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.182 A5 Pimephales promelas Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.228 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00156 A5 Daphnia magna, growth High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.00075 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 14.2 A5 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0779 A5 Navicula pelliculosa Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.024 A5 High
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.14 A5 High
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 120 R4 Bombus terrestris Low
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 4.97 R4 Bombus terrestris Moderate
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 9.33 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 0.132 Mortality
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 0.0885 Mortality
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 4mg kg-1, 28days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for spinetoram

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class - - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.025 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.0065 A5 -
Dermal penetration studies (%) 5-11 A5 Concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C3; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Potential for slow accumulation in the body
Possible thyroid toxicant
Weak sensitiser
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317
EC Risk Classification Click here to view information omn the EU risk phrases Reproduction risk category 3: R62
T - Toxic: R48/22
Xn - Harmful: R43
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for spinetoram

Language Name
English spinetoram
French -
German -
Danish -
Italian -
Spanish espinetoram
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Saturday 29 June 2019
Contact: aeru@herts.ac.uk