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GET ADDITIONAL DATA HERE!
diflufenzopyr (Ref: HSDB 7010)
** BAS 654H ** SAN 835H ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for diflufenzopyr

Description: Used, post-emergence, to control annual broad-leaved and perennial weeds in a variety of crops

Example pests controlled: Knotweed; Lambsquarters; Mallow; Buckweed; Nightshade; Morning glory; Bindweed; Ragweed; Smartweed; Sowthistle; Johnson grass; Milkweed

Example applications: Pasture; No-tlll burndown (Corn; Soybeans); Non-cropped land including rangeland, fallow

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1999, USA and Canada

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric
Chemical formula C15H12F2N4O3
Canonical SMILES CC(=NNC(=O)NC1=CC(=CC(=C1)F)F)C2=C(C=CC=N2)C(=O)O
Isomeric SMILES C/C(=N\NC(=O)NC1=CC(=CC(=C1)F)F)/C2=C(C=CC=N2)C(=O)O
International Chemical Identifier key (InChIKey) IRJQWZWMQCVOLA-DNTJNYDQSA-N
International Chemical Identifier (InChI) InChI=1S/C3H2F4O2.Na/c4-1(5)3(6,7)2(8)9;/h1H,(H,8,9);/q;+1/p-1
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Semicarbazone
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Systemic, works by inhibiting auxin transport
CAS RN 109293-97-2
EC number -
CIPAC number None allocated
US EPA chemical code 005107
PubChem CID 6125184
Molecular mass (g mol-1) 334.28
PIN (Preferred Identification Name) 2-[(1E)-1-{2-[(3,5-difluorophenyl)carbamoyl]hydrazinylidene}ethyl]pyridine-3-carboxylic acid
IUPAC name 2-{(EZ)-1-[4-(3,5-difluorophenyl)semicarbazono]ethyl}nicotinic acid
CAS name 2-[1-[[[(3,5-difluorophenyl)amino]carbonyl]hydrazono]ethyl]-3-pyridinecarboxylic acid
Other status information Marine polluant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) P
Herbicide Resistance Classification (WSSA) 19
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Off-white coloured granular solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
  • Sandoz
Example products using this active
  • Distinct
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as wettable granules for ground application using standard commercial sprayers.


ENVIRONMENTAL FATE

for diflufenzopyr

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 5850 F3 High
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 135.5 F3 -
Boiling point (oC) - - -
Degradation point (oC) 155 F3 -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.23 X 1001 Calculated -
Log P 1.09 F3 Low
Bulk density (g ml-1)/Specific gravity 0.24 F3 -
Dissociation constant (pKa) at 25oC 3.18 L3 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 0.01 F3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 7.0 X 10-05 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.35 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.63 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 14 L3 Non-persistent
DT50 (lab at 20oC) - - -
DT50 (field) 4.5 L3 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note General literature DT50 range 8-18 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 17 L3 Slow
Note pH sensitive: DT50 7 days at pH 5, 13 days at pH 9
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 24 L3 Non-persistent
Note pH sensitive: DT50 13 days at pH 5, 26 days at pH 9
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - Q3 Moderately mobile
Koc 87
Notes and range General literature Koc range 18-156 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
8-methyl-5-hydroxy-pyrido(2,3-d)-pyridazine - - - -
3,5-difluoroaniline - - - -
6-((3,5-difluorophenyl) carbamoyl)-8-methyl-pyrido (2,3-d)-5-pyridazinone carbamoyl phthalazinone - - -
2-acetyl nicotinic acid - - - -
N-(3,5-difluorophenyl)carbamate - - - -
8-methylpyrido[2,3-d]pyridazine-2,5(1H, 6H)-dione - - - -
8-hydroxymethyl-5(6H)pyrido[2,3-d]pyridazinone - - - -
8-hydroxymethylpyrido[2,3-d]pyridazine-2,5(1H,6H)-dione - - - -


ECOTOXICOLOGY

for diflufenzopyr

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk Q3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F3 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 26.0 L3 Dog High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 L3 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 16970 mg/Kg BW F4 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 106 L3 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 15.0 F4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 0.35 F4 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 0.1 F4 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 75.0 F3 Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 F4 Eisenia foetida Low
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for diflufenzopyr

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F3 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 F3 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.93 F3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.26 L3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E0

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible testicular, kidney, lung, spleen and brain toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport code 9
CLP classification 2013 Health: H319, H332
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20
Xi - Irritant: R36
N - Dangerous for the environment: R52
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
UN Number 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for diflufenzopyr

Language Name
English diflufenzopyr
French -
German -
Danish -
Italian -
Spanish diflufenzopir
Greek -
Slovenian -
Polish diflufenzopyr
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 25 May 2018
Contact: aeru@herts.ac.uk