Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

acetochlor (Ref: CP 55097)
** ICIA-5676 ** acetochlore ** R0 25538 ** MON 097 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Acetochlor is a herbicide that is currently not approved for EU use. It is moderately soluble in water and is quite volatile. Based on its chemical properties it would not be expected to leach to groundwater. It is not persistence in soil systems but may be very persistent in aquatic systems under certain conditions. It has a high mammalian toxicity and it has a low potential for bioaccumulation. It is a known mutagen and may cause undesirable reproduction/development effects. Acetochlor is a recognised irritant and skin sensitizer. Acetochlor is moderately toxic to birds, honeybees, earthworms and most aquatic organisms however it is highly toxic to algae.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for acetochlor

Description: A chloroacetanilide herbicide used mainly pre-emergence or pre-planting to control annual grasses and some broad-leaved weeds

Example pests controlled: Annual grasses including feathertop chloris, goosegrass, sweet buffalo grass and crab grass; Certain broadleaf weeds including morning glory, marigold, pigweed and cocklebur; Yellow nutsedge

Example applications: Vegetables including cabbage, peas and onions; Fruit including citrus, apples, pears, plums, apricots; Coffee; Corn; Sugarbeet; Sugarcane; Potatoes

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1985

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Spain
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism E/Z isomerisation
Chemical formula C14H20ClNO2
Canonical SMILES CCC1=CC=CC(=C1N(COCC)C(=O)CCl)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) VTNQPKFIQCLBDU-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H20ClNO2/c1-4-12-8-6-7-11(3)14(12)16(10-18-5-2)13(17)9-15/h6-8H,4-5,9-10H2,1-3H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Chloroacetamide
Minimum active substance purity 940 g/kg
Known relevant impurities EU DAR dossier - Ethyl chloroacetate 6 g/kg; 2-ethyl-6-methylaniline 3 g/kg
Substance origin Synthetic
Mode of action Selective, absorbed mainly by shoots and roots of germinating weeds. Inhibition of VLCFA (inhibition of cell division)
CAS RN 34256-82-1
EC number 251-899-3
CIPAC number 496
US EPA chemical code 121601
PubChem CID 1988
Molecular mass (g mol-1) 269.77
PIN (Preferred Identification Name) 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide
IUPAC name 2-chloro-N-ethoxymethyl-6'-ethylacet-o-toluidide
CAS name 2-chloro-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide
Other status information Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) K3
Herbicide Resistance Classification (WSSA) 15
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Pale yellow liquid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Monsanto
  • Dow Agrosciences
Example products using this active
  • Harness
  • Trophy
  • Trophee
  • Acenit
  • Guardian
  • Sacemid
  • Surpass
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an emulsifiable concentrate or capsule suspension that is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for acetochlor

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 282 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 5000000 A5 - Acetone -
500000 A5 - Ethyl acetate -
756000 C4 - Toluene -
100000 C4 - Ethanol -
Melting point (oC) 10.6 A5 -
Boiling point (oC) 172 A5 -
Degradation point (oC) 238 A5 -
Flashpoint (oC) 160 A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.38 X 1004 Calculated -
Log P 4.14 A5 High
Bulk density (g ml-1)/Specific gravity 1.12 A5 -
Dissociation constant (pKa) at 25oC Not applicable Q3 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 2.2 X 10-02 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.1 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.58 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.22 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 273nm = 448, 265nm = 538; [Acid solution: 273nm = 466, 265nm = 552 A5 -
Surface tension (mN m-1) 46.3 A5 20 oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 14 C4 Non-persistent
DT50 (lab at 20oC) 10.6 A5 Non-persistent
DT50 (field) 12.1 A5 Non-persistent
DT90 (lab at 20oC) 40.4 A5 -
DT90 (field) 40.2 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 3.4-29 days, DT90 range 11.1-96.3 days; field studies DT50 range 7-17 days, DT90 range 23.3-56.5 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 1.64 R3 -
Note Rice, whole plant, n=1
Aqueous photolysis DT50 (days) at pH 7 Value Stable A3 -
Note Not a major route of degradation
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable between pH 5 and pH 9
Water-sediment DT50 (days) 19.7 A5 Fast
Water phase only DT50 (days) 40.5 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 3.21 A5 Moderately mobile
Koc 156
Notes and range EU dossier Kd range 0.13-17.0 mL/g, Koc range 28-377 mL/g, Soils=10
Freundlich Kf 4.50 A5 Moderately mobile
Kfoc 285
1/n 1.21
Notes and range EU dossier kf range 0.37-20 mL/g, Kfoc range 74.0-600 mL/g, 1/n range 0.79-2.16, Soils=13
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
t-sulfonic acid This metabolite may cause environmental pollution, click here for further information Soil   0.118   Major fraction, Relevant
t-oxanilic acid (Ref: MON 52766) This metabolite may cause environmental pollution, click here for further information Soil   0.171   Major fraction, Relevant
t-sulfinylacetic acid (Ref: MON 52709) This metabolite may cause environmental pollution, click here for further information Soil   0.18   Major fraction, Relevant
acetic acid Soil   -   Not relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-[(2-ethyl-6-methylphenyl)amino]-2-oxoethanesulfonic acid acetochlor M13; s-sulfonic acid Soil; Water; Groundwater - -
N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide acetochlor M06; t-norchloroacetochlor Soil; Water; Groundwater - -
[(6-ethyl-3-hydroxy-2-methylphenyl)amino](oxo)acetic acid acetochlor M68 Plant - -


ECOTOXICOLOGY

for acetochlor

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 20 A5 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 1929 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) > 10 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 928 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) 1057 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 0.36 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.13 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 8.3 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.022 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 1.9 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 1.6 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.0027 A3 Lemna gibba High
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0036 A5 Pseudokirchneriella subcapitata High
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.00059 A5 Selenastrum capricornutum High
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 200 A5 Apis mellifera Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Apis mellifera Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 105.5 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 1.56 A5 Aphidius rhopalosiphi -
% Effect 100 Mortality
Dose: 2.025 g ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 831 A5 Typhlodromus pyri -
% Effect 97 Mortality
Dose: 2.025 g ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: maximum field rate, 100 days
-
Mesocosm study data NOEAEC mg l-1 0.002 A5 lotic systems -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for acetochlor

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1929 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 3.99 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0036 A2 Mouse, SF=300 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 1.5 A2 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.02 A2 Dog, SF=100 -
Dermal penetration studies (%) 0.05-50 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Minimal risk from any route
Source: US EPA
Occupational Dermal absorption possible during handling
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E1

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Slightly toxic
Thyroid, liver and kidney toxicant
USEPA - some evidence to suggest human carcinogen
Endocrine issues - Interaction with uterine estrogen receptors
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Avoid generation of dusts
IMDG Transport Code is usually 9
Not explosive or oxidising
CLP classification 2013 Health: H315, H317, H332, H335
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20, R43
Xi - Irritant: R37/38
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S60, S61
WHO Classification III - Slightly hazardous
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for acetochlor

Language Name
English acetochlor
French acetochlore
German Acetochlor
Danish acetochlor
Italian acetoclor
Spanish acetoclor
Greek -
Slovenian acetoklor
Polish acetochlor
Swedish -
Hungarian acetoklor
Dutch -

Record last updated: Saturday 02 November 2019
Contact: aeru@herts.ac.uk