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chlordimeform (Ref: ENT 27335)
** chlorfenamidine ** HSDB 1537 ** chlorophenamidin ** chlorophedine ** chlorophenamidine ** Schering 36 268 ** C 851 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Chlordimeform in an insectiicde and acaricide that is not approved for use in the EU. It is moderately soluble in water and highly soluble in many organic solvents. It is volatile. Under normal conditions is would not be expected to leach to groundwater. It is moderately persistent in soil systems but would not be expected to persist in water systems. It is moderately toxic to mammals, a neurotoxin and has a high potential for bio-concentration. It is moderately toxic to birds and fish but less so to honeybees.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chlordimeform

Description: An obsolete substance once used on a wide variety of crops to control mites and other insects. It has also been used to control livestock external parasites and stem borers in irrigated rice.,

Example pests controlled: Mites; Ticks; Some Lepidoptera insects

Example applications: Fruit; Vegetables; Cotton

Efficacy & activity: -

Availability status: Obsolete

Introduction & key dates: circa 1966

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database No

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C10H13ClN2
Canonical SMILES CC1=C(C=CC(=C1)Cl)N=CN(C)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) STUSTWKEFDQFFZ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H13ClN2/c1-8-6-9(11)4-5-10(8)12-7-13(2)3/h4-7H,1-3H3
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Chlordimeform - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Acaricide, Insecticide, Ovicide
Substance group Formamidine
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Broad spectrum acaricide that appears to interfere with the amine-mediated control of nervous and endocrine systems
CAS RN 6164-98-3
EC number 228-200-5
CIPAC number 277
US EPA chemical code 059701
PubChem CID 22544
Molecular mass (g mol-1) 196.68
PIN (Preferred Identification Name) (E)-N'-(4-chloro-2-methylphenyl)-N,N-dimethylmethanimidamide
IUPAC name N2-(4-chloro-o-tolyl)-N1,N1-dimethylformamidine
CAS name N'-(4-chloro-2-methylphenyl)-N,N-dimethylmethanimidamide
Other status information Chemical subject to PIC regulations; PAN Listed as Highly Hazardous Chemical; Rotterdam Convention (Class O)
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not known
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Boophilus microplus
Panonychus ulmi
Tetranychus urticae
Physical state Colourless crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Ciba-Geigy
  • Schering
  • Quimica Estrelle
Example products using this active
  • Ovatoxion
  • Spanone
  • Galecron
  • Fundal
  • Bermat
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually formulated as an emulsifiable concentrate of water-soluble powder.


ENVIRONMENTAL FATE

for chlordimeform

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 270 V3 - @ 25 DegC Moderate
Solubility - In organic solvents at 20oC (mg l-1) 200000 V3 - Acetone -
200000 V3 - Ethyl acetate -
200000 V3 - Chloroform -
200000 V3 - Benzene -
Melting point (oC) 35 F4 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable CA3 -
Octanol-water partition coefficient at pH 7, 20oC P 7.76 X 1002 Calculated -
Log P 2.89 V3 Moderate
Bulk density (g ml-1)/Specific gravity 1.10 V3 -
Dissociation constant (pKa) at 25oC 6.8 V3 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 48.0 V3 - @ 25 degC Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 0.896 F3 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.55 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 4.01 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 30 V3 Moderately persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note General sources: DT50 20-40 days (R3)
Dissipation rate RL50 on plant matrix Value 0.4 R4 -
Note Published literature RL50 range 0.1-0.95 days, cotton leaves, n=3
Dissipation rate RL50 on and in plant matrix Value 3.6 R3 -
Note Green tea leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 2.0 V3 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - CA2 Slightly mobile
Koc 890
Notes and range Estimated
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for chlordimeform

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk Q3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 160 V3 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - R3 Rat -
(ppm diet) 2.0 -
Birds - Acute LD50 (mg kg-1) > 1749 R3 Coturnix japonica Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 11.7 V3 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) - - -
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 120 V3 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chlordimeform

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 160 V3 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 263 V3 Rat -
Mammals - Inhalation LC50 (mg l-1) > 17.4 R3 Mammal -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public -
Occupational May be absorbed through the skin
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Observed links with bladder cancer and urinary bladder irritation
May act as blood toxicant
IARC Group 3 carcinogen; USEPA - probable human carcinogen
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of dust
May emit toxic fumes in a fire
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Xn - Harmful: R21, R22
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S22, S36/36, S60, S61
WHO Classification O - Obsolete substance
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for chlordimeform

Language Name
English chlordimeform
French chlordimeforme
German Chlordimeform
Danish -
Italian -
Spanish clordimeform
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk