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2-naphthyloxyacetic acid
** NOA ** BNOA ** Beta-NOA ** 2-NOA ** Beta-naphthyloxyacetic acid ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for 2-naphthyloxyacetic acid

Description: Used as plant hormone to promote the growth of roots, to encourage fruit set and to prevent fruit from falling prematurely

Example pests controlled: Growth processes; Fruit setting

Example applications: Fruit including apples, pears, plums, cherries

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1940

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur France
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C12H10O3
Canonical SMILES -
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RZCJYMOBWVJQGV-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H10O3/c13-12(14)8-15-11-6-5-9-3-1-2-4-10(9)7-11/h1-7H,8H2,(H,13,14)
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
2-naphthyloxyacetic acid - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Plant growth regulator, Herbicide
Substance group Synthetic auxin
Minimum active substance purity 995 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Absorbed by leaves and roots
CAS RN 120-23-0
EC number 204-380-0
CIPAC number 664
US EPA chemical code 055601
PubChem CID 8422
Molecular mass (g mol-1) 202.21
PIN (Preferred Identification Name) -
IUPAC name 2-naphthoxyacetic acid
CAS name (2-naphthyloxy)acetic acid
Other status information Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Synchemicals Ltd
  • Unicrop
Example products using this active
  • Alligante 36c
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a liquid concentrate.


ENVIRONMENTAL FATE

for 2-naphthyloxyacetic acid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 203 A3 - @ pH >3 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 6.1 A5 - n-Hexane -
790 A5 - Toluene -
140 A5 - Methanol -
160000 A5 - Acetone -
Melting point (oC) 155 A5 -
Boiling point (oC) 363.5 A5 -
Degradation point (oC) No decomposition A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.16 X 1002 Calculated -
Log P 2.50 A4 Low
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 3.55 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 2.89 X 10-03 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.06 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.78 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 8.40 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 227nm = 40560-48600 A3 -
Surface tension (mN m-1) 54.4 A5 100 mg l-1 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 3.5 A3 Non-persistent
DT50 (lab at 20oC) 53.4 A5 Moderately persistent
DT50 (field) - - -
DT90 (lab at 20oC) 195 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier DT50 lab studies range 18.1-100.5 days, DT90 range 10-443 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 0.37 A4 Fast
Note 0.86 days sunlight at 40degN
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) 53.3 A5 Moderately fast
Water phase only DT50 (days) 28.9 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 1.12 A5 Mobile
Koc 72.0
Notes and range EU dossier Kd range 0.33-2.43 mL/g, Koc range 37.5-113.0 mL/g, Soils=4
Freundlich Kf 1.03 A5 Mobile
Kfoc 65.0
1/n 0.78
Notes and range EU dossier Kf range 0.287-2.37, kfoc range 32.6-1100 mL/g, 1/n range 0.74-0.83, Soils=4
pH sensitivity No

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
[(6-hydroxy-2-naphthyl)oxy]acetic acid - Rat (Urinary) - -


ECOTOXICOLOGY

for 2-naphthyloxyacetic acid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 1417 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Coturnix japonica Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 2.39 A4 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 10 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 4.52 A4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 6.7 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.19 A4 Lemna gibba Moderate
Non-target plants 50.5 A5 Carrot
Vegetative vigour, ER50
as g product/ha (Product Conc 4.5% a.s.)
-
117.8 A5 Carrot
Seeling emergence, ER50
as g product/ha (Product Conc 4.5% a.s.)
-
Algae - Acute 72 hour EC50, growth (mg l-1) 29 A5 Desmodesmus subspicatus Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 200 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A4 as formulation (product conc 4.5% a.s.) Low
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 50.4 >, Mortality as g product ha-1 (Product Conc 4.5% a.s.)
A3 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 50.4 >, Mortality as g product ha-1 (Product Conc 4.5% a.s.)
A3 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for 2-naphthyloxyacetic acid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1417 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 4.87 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A5 Rat, SF=1000 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.6 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.03 A5 Rat, SF=300 -
Dermal penetration studies (%) 3.52-10.54 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Acceptable for approved use
Occupational Acceptable for approved use
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

A3; B0; C0; D0; E0

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues May cause convulsions, coma, ecephalopathy and kernicterus
Kidney & liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
Xi - Irritant: R36/37/38
EC Safety Classification Click here to view information omn the EU safety phrases S24/25, S36/37/39
WHO Classification II - Moderately hazardous
UN Number Not regulated
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for 2-naphthyloxyacetic acid

Language Name
English 2-naphthyloxyacetic acid
French acide naphthyloxyacetique
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk