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diphenylamine
** DPA ** anilinobenzene ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for diphenylamine

Description: Used mainly to control post-harvest disease and damage in apples and pears via both pre- and post-harvest treatments

Example pests controlled: Fruit skin scald

Example applications: Fruit including apples, pears

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Ireland
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C12H11N
Canonical SMILES C1=CC=C(C=C1)NC2=CC=CC=C2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) DMBHHRLKUKUOEG-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H11N/c1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h1-10,13H
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Diphenylamine - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Plant growth regulator, Fungicide, Insecticide
Substance group Amine
Minimum active substance purity 987 g/kg
Known relevant impurities EU dossier - Aniline <5 mg/kg, 4-aminobiphenyl <2 mg/kg, 2-aminobiphenyl 6.5 mg/kg
Substance origin Synthetic
Mode of action An inhibitor of polyene and isoprene biosynthesis
CAS RN 122-39-4
EC number 204-539-4
CIPAC number 460
US EPA chemical code 038501
PubChem CID 11487
Molecular mass (g mol-1) 169.23
PIN (Preferred Identification Name) N-phenylaniline
IUPAC name diphenylamine
CAS name N-phenylbenzenamine
Other status information WFD - phs; Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not known
Fungicide Resistance Classification (FRAC) Not known
Examples of recorded resistance -
Physical state White to tan coloured crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Cerexagri SA
Example products using this active
  • No Scald DPA 31
UK LERAP status None
Formulation and application details Usually supplied as an emulsifiable concentrate that is diluted with water and used as a post-harvest drench. .


ENVIRONMENTAL FATE

for diphenylamine

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 25.8 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 37000 A5 - n-Hexane -
450000 A5 - Methanol -
1000000 A5 - Acetone -
1000000 A5 - Ethyl acetate -
Melting point (oC) 53 A5 -
Boiling point (oC) 298.8 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 6.61 X 1003 Calculated -
Log P 3.82 A5 High
Bulk density (g ml-1)/Specific gravity 1.18 R3 -
Dissociation constant (pKa) at 25oC 1.03 A4 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 0.852 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 0.321 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value - - -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - - -
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 204nm = 4.49, 284nm = 4.32; [Acidic solution: 204nm = 4.75, 284nm = 4.57; [Basic solution: 204nm = 4.37, 284nm = 4.37 A5 -
Surface tension (mN m-1) 71.8 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) - - -
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note: -
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 0.2 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 353 A5 Persistent
Note pH variable: 316 days at pH 5, 352 days at pH 7, 359 days at pH 9, all at 25 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - R3 Non-mobile
Koc 4104
Notes and range Literature values range 1212-6590 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
carbazole - Water (Photolysis) - -
hydroxydiphenylamine - Water (Photolysis) - -


ECOTOXICOLOGY

for diphenylamine

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 15000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 2.2 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.71 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 1.2 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) > 0.38 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.30 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.04 A5 Selenastrum capricornutum Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for diphenylamine

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 15000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 7500 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.075 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.1 A5 Dog 90day, SF=100 -
Dermal penetration studies (%) 100 A3 default -
Dangerous Substances Directive 76/464 - - -
Exposure Limits [UK LT TWA 8 hr:10 mg/m3], [UK STEL 15 mins: 20 mg/m3] UK EA QS database, 2018 -
Exposure Routes Public Negligible risk to the public and consumers
Occupational Potential exposure via dermal contact - PPC advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 90 A5 Dog -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Gastrointestinal, cardiovascular, kidney and liver toxicant
May cause methemoglobinemia
Maycause splenic congestion

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of dust
Not explosive or oxidising
IMDG Transport Code is usually 9 or 6.1
CLP classification 2013 Health: H315, H317
Environment: H413
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R23, R24, R25, R33
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S28, S36/37, S45, S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number Usualy 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for diphenylamine

Language Name
English diphenylamine
French -
German -
Danish -
Italian -
Spanish difenilamina
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk