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chlordane (Ref: OMS 1437)
** M140 ** ENT 9932 ** aspon-chlordane ** kypchlor ** chlorodane ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Chlordane is an insecticide that is not approved for use in the EU. It has a low aqueous solubility, is quite volatile and is not normally expected to leach to groundwater. It can be very persistent in both soil and water systems. It is moderately toxic to mammals and has a high potential for bio-concentration. It is also neurotoxic and a skin and eye irritant. It is highly toxic to birds, fish and moderately toxic to honeybees.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chlordane

Description: An organochlorine insecticide once commonly used to control a range of pests but now obsolete and banned

Example pests controlled: Termites; Ants; Wasps; Cockroaches

Example applications: Corn; Citrus; Vegetables; Turf & laens

Efficacy & activity: -

Availability status: Obsolete

Introduction & key dates: circa 1950

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Expired/Banned
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule. Chlordane is a a complex mixture of isomers, other chlorinated hydrocarbons, and a range of by-products
Chemical formula C10H6Cl8
Canonical SMILES C1C2C(C(C1Cl)Cl)C3(C(=C(C2(C3(Cl)Cl)Cl)Cl)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) BIWJNBZANLAXMG-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H6Cl8/c11-3-1-2-4(5(3)12)9(16)7(14)6(13)8(2,15)10(9,17)18/h2-5H,1H2
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Organochlorine
Minimum active substance purity -
Known relevant impurities Technical chlordane may contain a large number of different compounds including chlordane isomers
Substance origin Synthetic
Mode of action Non systemic with contact, stomach and respiratory action. GABA-gated chloride channel antagonist.
CAS RN 57-74-9
EC number 200-349-0
CIPAC number 13
US EPA chemical code 058201
PubChem CID 5993
Molecular mass (g mol-1) 409.78
PIN (Preferred Identification Name) (1E,2E,3aE,4E,7E,7aE)-1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
IUPAC name 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methanoindene
CAS name 1,2,4,5,6,7,8,8-octachloro-2,3,3a,4,7,7a-hexahydro-4,7-methano-1H-indene
Other status information Chemical subject to PIC regulations; POP - regulated by Stockholm Convention; PAN Dirty Dozen; LRTAP Annex I; OSPAR soc; Marine Pollutant; Rotterdam Convention (Class II)
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 2A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Blattella germanica
Conoderus falli
Ctenocephalides felis
Epitrix tuberis
Psilia rosae
plus others
Physical state Straw coloured viscous liquid in raw state but powder in product form
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Velsicol
  • Dow
Example products using this active
  • Toxichlor
  • Kypchlor
  • Dowchlor
  • Octachlor
  • Belt
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available in a variety of different formulations including enulsifiable concentrates, granules, dusts, wettable powders and oils.


ENVIRONMENTAL FATE

for chlordane

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.1 G4 Low
Solubility - In organic solvents at 20oC (mg l-1) Miscible L3 - Acetone -
Miscible L3 - Ethanol -
Miscible L3 - Cyclohexanone -
Miscible L3 - Isopropanol -
Melting point (oC) 106 F4 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 6.03 X 1002 Calculated -
Log P 2.78 G4 Moderate
Bulk density (g ml-1)/Specific gravity 1.61 F4 -
Dissociation constant (pKa) at 25oC Not applicable Q3 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 1.3 G4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 0.00039 Q3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.77 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 365 L3 Very persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Other sources: DT50 approx 1 year - persistent (R2); 283 days to 3.8 years (R3); FAO state DT50 = 4 years
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 26.6 R4 -
Note Published literature RL50 range 2.3-76.0 days, 4 field crops, various matrices, n=4
Aqueous photolysis DT50 (days) at pH 7 Value Stable P2 -
Note Not significant degradation route but rate increases in presence of other chemicals such as acetone
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable P2 -
Note Not significant degradation route
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - G3 Non-mobile
Koc 20000
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
oxychlordane Soil   -   Not assessed under 91/414 or 1107/2009


ECOTOXICOLOGY

for chlordane

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 8460 F3 (Whole body, Literature values log BCF range 4.3-4.4 (R3)) High potential
CT50 (days) 1 -
Mammals - Acute oral LD50 (mg kg-1) 460 F4 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 5 G3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 83 L3 Colinus virginianus High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.09 L3 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.59 L3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.07 J3 Daphnia magna, LOEC Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) 0.01 R3 Chironomus plumosus High
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 6.0 F3 Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chlordane

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 460 F4 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 200 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 0.56 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0005 JMPR 1994 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Routes Public Via inhalation and dermal absorption but exposure unlikely as substance obsolete
Source: US EPA
Occupational May be absorbed from the gastrointestinal tract, by inhalation and through the intact skin
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards Non-statutory WHO drinking water guideline 0.0002 mg/L UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E3

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues May cause mental confusion and convulsions
IARC Group 2B carcinogen
Possible liver & kidney toxicant
Endocrine issues - Competitive binding to androgen receptors
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of mists
Flammable
Corrosive to some metals
CLP classification 2013 Health: H302, H312, H351
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Xn - Harmful: R21/22
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S60, S61
WHO Classification II - Moderately hazardous
UN Number 2996
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for chlordane

Language Name
English chlordane
French chlordane
German Chlordan
Danish chlordane
Italian clordano
Spanish clordano
Greek chlordane
Slovenian klordan
Polish chlordan
Swedish -
Hungarian -
Dutch chloordaan

Record last updated: Tuesday 26 November 2019
Contact: aeru@herts.ac.uk