Toluene 2,4-diisocyanate
Last updated: 17/08/2023
(Also known as: TDI; tolylene diisocyanate)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
 
Substance with no pesticidal activity but sometimes used as a solvent or carrier in product formulations.
-
-
Not applicable
Not applicable
Not applicable
EC Regulation 1107/2009 (repealing 91/414)
Not applicable
Not applicable
Not applicable
Not applicable
No
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
Isomeric mixture
C₉H₆N₂O₂
-
-
-
-
Yes
Other substance
Solvent, Carrier
Aromatic diisocyanate
-
-
Synthetic
Inert
26471-62-5
247-722-4
-
-
-
174.16
-
2,4-diisocyanato-1-methylbenzene
methyl phenylene diisocyanate
-
-
Not applicable
Not applicable
Not applicable
Not applicable
-
Colourless to pale straw coloured liquid
37.6
(reacts)
Low
-
-
-
21.8
-
-
-
-
-
-
-
-
-
-
5.50 X 1003
Calculated
-
3.74
High
-
-
-
-
-
-
1.214
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
-
-
-
-
1300
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Highly volatile
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
General literature states circa 5.5% of the original material remains after 24hr
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Soil adsorption and mobility
-
-
-
Cannot be calculated
-
-
-
-
-
-
-
-
-
-
-
-
-
-
None
Terrestrial ecotoxicology
4130
Rat
Low
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
133
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Oncorhynchus mykiss
Low
-
-
-
12.5
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
3230
E2 E = Manufacturers safety data sheets 2 = Unverified data of unknown source
Unknown species
Low
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
4130
Rat
Low
9400
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
-
0.48
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat 1 hr
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Can be absorbed into the body by inhalation of its vapour and by inhalation of its aerosol and by ingestion
EU MRL pesticide database 
-
-
-
-
-
-
-
-
-
-
Carcinogen
Endocrine disruptor
No data found
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
No data found
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Vapour may cause or exacerbate asthma Vapour may cause chemical bronchitis Cardiovascular and blood toxicant
Combustible Emits irritating or toxic emissions in a fire IMDG Transport Hazard Class 6.1
-
Not listed (Not listed)
UN2078
Packaging Group II (moderate danger)
-
toluene 2,4-diisocyanate
di-isocyanate de toluylene
Tuluylendiisocyanat
-
toluen-disocianato
-
-
toluilenodwuizocyjanian
-
-
tolueen-diisocyanaat
-
Record last updated:
17/08/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242