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GET ADDITIONAL DATA HERE!
chlorfenvinphos (Ref: OMS 166)
** clofenvinfos ** CVP ** OMS 1328 ** ENT 24969 ** CGA 26351 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the VSDB

SUMMARY

Chlorfenvinphos is an insecticide that is not approved for use in the EU. It has a moderate aqueous solubility and is miscible with many organic solvents. It is relatively volatile and there is some risk that it may leach to groundwater. It is moderately persistent in soil systems. It is highly toxic to mammals, an endocrine distruper, a neurotoxin and an inhibitor of cholinesterase. In addition there is some concern that it may bio-concentrate. Chlorfenvinphos is highly toxic to birds, honeybees and aquatic invertebrates. It is moderately toxic to fish and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chlorfenvinphos

Description: A soil applied insecticide used to control root-flies, rootworms and other soil pests. Also used as a sheep dip.

Example pests controlled: Ticks; Livestock flies; Mites; Root flies; Rootworms; Colorado beetle; Leafhoppers

Example applications: Potatoes; Rice; Vegetables including brassicas, swedes, turnips, carrots, onions; Citrus; Sugarcane; Sweetcorn

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1962

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Germany
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, S. Africa, South & Central America, kenya

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Exists in two geometric isomeric forms: alpha (cis) isomer and beta (trans) isomer.
Chemical formula C12H14Cl3O4P
Canonical SMILES CCOP(=O)(OCC)OC(=CCl)C1=C(C=C(C=C1)Cl)Cl
Isomeric SMILES CCOP(=O)(OCC)O/C(=C\Cl)/C1=C(C=C(C=C1)Cl)Cl
International Chemical Identifier key (InChIKey) FSAVDKDHPDSCTO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H14Cl3O4P/c1-3-17-20(16,18-4-2)19-12(8-13)10-6-5-9(14)7-11(10)15/h5-8H,3-4H2,1-2H3/b12-8-
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Acaricide, Veterinary substance
Substance group Organophosphate
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 470-90-6
EC number 207-432-0
CIPAC number 88
US EPA chemical code 084101
PubChem CID 5377784
Molecular mass (g mol-1) 359.6
PIN (Preferred Identification Name) (1E)-2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate
IUPAC name (EZ)-2-chloro-1-(2,4-dichlorophenyl)vinyl diethyl phosphate
CAS name 2-chloro-1-(2,4-dichlorophenyl)ethenyl diethyl phosphate
Other status information WFD priority substance; Marine, Surface and Groundwater Pollutant; Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards EU Directive 2008/105/EC EQS surface waters: annual average 0.1 ug/L; max measured 0.3 ug/L
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Ceutorhynchus assimilis
Culex pipiens pipiens
Meligethes aeneus
Rhizoglyphus robini
Spodoptera litura
plus others
Physical state Colourless to amber liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
  • Agro-Care
  • Zagro Singapore Pte. Ltd.
  • Kenogard
Example products using this active
  • Vinylphate
  • Birlane
  • Steladone
  • Supona
  • Apachlor
  • Haptarax
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available in a variety of formulations including emulsifiable concentrates, granules, seed treatments and wettable powders.


ENVIRONMENTAL FATE

for chlorfenvinphos

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 145 B5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) Miscible F4 - Acetone -
Miscible F4 - Ethanol -
Miscible F4 - Xylene -
Miscible F4 - Dichloromethane -
Melting point (oC) -20 F4 -
Boiling point (oC) 167 L3 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable L3 -
Octanol-water partition coefficient at pH 7, 20oC P 6.31 X 1003 Calculated -
Log P 3.8 B5 High
Bulk density (g ml-1)/Specific gravity 1.36 F4 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 0.53 B5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) - - -
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.72 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.04 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 40 B5 Moderately persistent
DT50 (lab at 20oC) 37 B4 Moderately persistent
DT50 (field) 30 B4 Moderately persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Lab studies DT50 range 6-98 days, field study range 12-45 days; FAO state DT50 10-45 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 20.2 R3 -
Note Lemon fruit, n=1
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 125 B4 Persistent
Note pH and temperature sensitive: DT50 29 days at pH 1 and 38 degC, 17 days at pH 9 and 38 degC, 1.3 hours at pH 13 and 20 degC, (L3)
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) 7 K4 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - B5 Slightly mobile
Koc 680
Notes and range Other literature data Koc 295 mL/g (R4)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for chlorfenvinphos

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 250 R3 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 12 B5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - B5 Rat -
(ppm diet) 3 -
Birds - Acute LD50 (mg kg-1) 80 B5 Colinus virginianus High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 1.1 B3 Salmonidae Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.03 Q2 Unknown species Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.00025 B4 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0001 P3 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 1.36 B5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 1 Q2 Unknown species Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.55 B5 High
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 130 Q3 Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmful AA2 Typhlodromus pyri -
Other arthropod (2) LR50 g ha-1 - - -
% Effect Harmless AA2 Chrysoperla carnea -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chlorfenvinphos

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 12 B5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 31 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 0.05 L3 Rat -
Other Mammal toxicity endpoints Intraperitoneal LD50 = 87.0 mg kg-1 V3 Mouse -
Intravenous LD50 = 87.0 mg kg-1 V3 Mouse -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0005 JMPR 1994 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Routes Public -
Occupational Dermal and inhalation during pesticide handling
Source: US EPA
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

A3; B0; C0; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

-

-

General human health issues May cause bradycardia or tachycardia
May cause Loss of muscle coordination, slurring of speech
May cause mental confusion, disorientation and drowsiness
Endocrine issues - Weak estrogen effect
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of mists
CLP classification 2013 Health: H300, H311
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R28
T - Toxic: R24
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S28, S36/37, S45, S60, S61
WHO Classification Ib - Highly hazardous
UN Number 3018
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for chlorfenvinphos

Language Name
English chlorfenvinphos
French chlorfenviphos
German Chlorfenvinphos
Danish chlorfenvinphos
Italian clorfenvinfos
Spanish clorfenvinfos
Greek chlorfenvinphos
Slovenian klorfenvinfos
Polish chlorfenwinfos
Swedish klorfenvinfos
Hungarian -
Dutch chloorfenvinfos

Record last updated: Tuesday 22 May 2018
Contact: aeru@herts.ac.uk