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propisochlor
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for propisochlor

Description: Pre-emergence or pre-plant herbicide for control of annual grasses and some broad leaved weeds

Example pests controlled: Cockspur grass; goose grass; Green bristlegrass; Goosefoot grass; Black nightshade

Example applications: Maize; Potatoes; Soybean; Corn; Peanuts; Rice; Spring OSR; Sunflower; peas; Wheat; Barley

Efficacy & activity: -

Availability status: Banned in many countries

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Hungary
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Russia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule with two enantiomers - S- and R-. The technical material is an isomeric mixture but it is the R-isomer that exhibits the strongest herbicidal activity.
Chemical formula C15H22ClNO2
Canonical SMILES CCC1=CC=CC(=C1N(COC(C)C)C(=O)CCl)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) KZNDFYDURHAESM-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H22ClNO2/c1-5-13-8-6-7-12(4)15(13)17(14(18)9-16)10-19-11(2)3/h6-8,11H,5,9-10H2,1-4H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Chloroacetanilide
Minimum active substance purity 943 g/kg
Known relevant impurities EU dossier - none declared
Substance origin Synthetic
Mode of action Inhibits protein synthesis and so blocks cell division, selective, absorbed by shoots of germinating plants. Inhibition of VLCFA (inhibition of cell division).
CAS RN 86763-47-5
EC number -
CIPAC number -
US EPA chemical code -
PubChem CID 167454
Molecular mass (g mol-1) 283.80
PIN (Preferred Identification Name) 2-chloro-N-(2-ethyl-6-methylphenyl)-N-[(propan-2-yloxy)methyl]acetamide
IUPAC name 2-chloro-6'-ethyl-N-isopropoxymethylacet-ortho-toluidide
CAS name 2-chloro-N-(2-ethyl-6-methylphenyl)-N-((1-methylethoxy)methyl)acetamide
Other status information Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) K3
Herbicide Resistance Classification (WSSA) 15
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Clear colourless liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Nitrokemia
  • Shandong
  • Arysta LifeSciences
Example products using this active
  • Proponit 720EC
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually applied as an aqueous spray.


ENVIRONMENTAL FATE

for propisochlor

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 90.8 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 483000 A5 - Acetone -
538000 A5 - Dichloromethane -
582000 A5 - Heptane -
598000 A5 - Methanol -
Melting point (oC) 21.8 A5 -
Boiling point (oC) 277 A5 -
Degradation point (oC) 150 A4 -
Flashpoint (oC) 146 A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1003 Calculated -
Log P 3.3 A5 High
Bulk density (g ml-1)/Specific gravity 1.0966 A5 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 3.1 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 9.67 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.36 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.26 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) 50.3 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 13 L3 Non-persistent
DT50 (lab at 20oC) 7.63 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 57.0 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 4.0-13.6 days, DT90 range 27.8-134 days; General literature states typical DT50 10-15 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 2.9 R4 -
Note Published literature RL50 range 1.14-4.73 days, various matrices from field grown maize & rice, n=2
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Stable at all relevant pH's
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 4 to pH 9 50 degC 5 days
Water-sediment DT50 (days) 14.7 A5 Fast
Water phase only DT50 (days) 8.5 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 3.21 A5 Moderately mobile
Kfoc 291
1/n 0.97
Notes and range EU dossier Kf range 4.13-3.047, Kfoc range 142-839 mL/g, 1/n range 0.89-1.17, Soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-((2-ethyl-6-methylphenyl) (isopropoxymethyl)amino)-2-oxoethane sulfonic acid This metabolite may cause environmental pollution, click here for further information Soil   0.210   Relevant, Major fraction
((2-ethyl-6-methylphenyl)(sopropoxymethyl)amino)(oxo)acetic acid This metabolite may cause environmental pollution, click here for further information Soi;   0.200   Relevant, Major fraction

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-[(2-ethyl-6-methylphenyl)amino]-2-oxoethane sulfonic acid Propisochlor M1 Soil 0.093 -
3-({2-[(2-ethyl-6-methylphenyl)amino]-2-oxoethyl}sulfinyl)-2-hydroxypropanoic acid Propisochlor M14; Propisochlor (s-sulfinyl lactic acid Plant up to 0.19 -
N-(2-ethyl-6-methylphenyl)-2-(hexopyranosyloxy)-N-[(propan-2-yloxy)methyl]acetamide Propisochlor M17; Propisochlor t-hydroxy glucoside Plant up tp 0.20 -
N-(2-ethyl-6-methylphenyl)-2-hydroxy-N-(isopropoxymethyl)acetamide Propisochlor M5 Soil 0.075 -
({2-[(2-ethyl-6-methylphenyl)(isopropoxymethyl)amino]-2-oxoethyl}sulfinyl)acetic acid Propisochlor M7 Soil 0.097 -
{(dimeric form of N-(2-ethyl-6-methylphenyl)-N-(isopropoxymethyl)-2-(mercapto)acetamide) Propisochlor M9 Soil 0.121 -


ECOTOXICOLOGY

for propisochlor

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 72.2 A4 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 2290 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 1562 A5 Coturnix japonica Moderate
Birds - Short term dietary (LC50/LD50) > 3905 mg kg diet-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 1.3 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.39 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 14.0 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 3.2 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.012 A5 Lemna gibba Moderate
Non-target plants > 2160 A5 Avena sativa
Seedling emergence, ER50
as g/ha
-
360 A5 Lolium perenne
Vegetative vigour, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.012 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.0042 A5 Scenedesmus subspicatus Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 111 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 248 A5 Eisenia foetida Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 20300 A5 Aphidius rhopalosiphi -
% Effect - - -
Other arthropod (2) LR50 g ha-1 1500 A5 Typhlodromus pyri -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 14.6 mg kg-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for propisochlor

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2290 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) > 5.0 A5 Rat, 4 hr (head only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.025 A4 Dog, SF=200 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A4 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.025 A4 Dog, SF=200 -
Dermal penetration studies (%) 1.5-17.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Risks acceptable for proposed uses - care required
Occupational Risk identified - PPE/PPC essential
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E0

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Ingestion may cause gastro-intestinal tract problems
Possible liver toxicant
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
Flammable
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R21
EC Safety Classification Click here to view information omn the EU safety phrases S36/37
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for propisochlor

Language Name
English propisochlor
French propisochlore
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Thursday 31 May 2018
Contact: aeru@herts.ac.uk