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Chlorothalonil (Ref: DS 2787)
Last updated: 18/08/2021
(Also known as: TPN; tetrachloroisophthalonitrile; m-TCPN; HSR002825)

SUMMARY
Chlorothalonil is a broad spectrum fungicide. It has a low aqueous solubility, is volatile and would not be expected to leach to groundwater. It is slightly mobile. It tends not to be persistent in soil systems but may be persistent in water. It has a low mammalian toxicity but there is some concern regarding its bioaccumulation potential. It is a recognised irritant. Chlorothalonil is moderately toxic to birds, honeybees and earthworms but considered to be more toxic to aquatic organisms.
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
Drainflow: Slightly mobile; Potential for particle bound transport: Medium
Ecotoxicity
High alert:
Fish acute ecotoxicity: High; Fish chronic ecotoxicity: High; Daphnia acute ecotoxicity: High; Daphnia chronic ecotoxicity: High
Human health
High alert:
Carcinogen; Reproduction/development effects
GENERAL INFORMATION
Description
A fungicide used to control a wide range of diseases on a broad range of crops. Also used as a wood preservative.
Example pests controlled
Rust; purple spot; Leaf blight; Anthracnose; Downy mildew; Ring spot; Stalk rot; Botrytis rot; Pod & stem blight
Example applications
Cereals; Vegetables including asparagus, beans, cabbage, cauliflower, broccoli, carrot, onions, celery, curcubits; Corn for seed; Fruit including cranberries, melon; Mushrooms; Peanuts; Potatoes
Efficacy & activity
Can be product specific but generally - Wheat/Mildew=Low; Wheat/Septori tritici=High; Barley/Rhynchosporium=Low; Barley/Ramularia=Moderate
Availability status
Current
Introduction & key dates
1964, first first reported
UK regulatory status
UK COPR regulatory status
Not approved
Date COPR inclusion expires
Expired
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Netherlands/Belgium
Date EC 1107/2009 inclusion expires
Expired
EU Candidate for substitution (CfS)
No
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
         
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
             
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
       
Additional information
Also used in
Australia, USA
Chemical structure
Isomerism
None
Chemical formula
C₈Cl₄N₂
Canonical SMILES
C(#N)C1=C(C(=C(C(=C1Cl)Cl)Cl)C#N)Cl
Isomeric SMILES
No data
International Chemical Identifier key (InChIKey)
CRQQGFGUEAVUIL-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C8Cl4N2/c9-5-3(1-13)6(10)8(12)7(11)4(5)2-14
2D structure diagram/image available?
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name Relationship Link
chlorothalonil -
General status
Pesticide type
Fungicide
Substance group
Chloronitrile
Minimum active substance purity
985 g kg⁻¹
Known relevant impurities
EU dossier - Hexachlorobenzene 0.04 g kg⁻¹; Decachlorobiphenyl 0.03 g kg⁻¹
Substance origin
Synthetic
Mode of action
Non-systemic, broad-spectrum, foliar action with some protectant properties. Acts by preventing spore germination and zoospore motility. Multi-site activity.
CAS RN
1897-45-6
EC number
217-588-1
CIPAC number
288
US EPA chemical code
081901
PubChem CID
15910
Molecular mass
265.91
PIN (Preferred Identification Name)
2,4,5,6-tetrachlorobenzene-1,3-dicarbonitrile
IUPAC name
tetrachloroisophthalonitrile
CAS name
2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile
Other status information
Currently being phased out in EU; PAN Bad Actor Chemical
Relevant Environmental Water Quality Standards
UK Environment Agency non-statutory standard for the protection of aquatic life: freshwater and saltwater annual average 0.1 µg l⁻¹, max acceptable conc 1.0 µg l⁻¹
Herbicide Resistance Classification (HRAC)
Not applicable
Herbicide Resistance Classification (WSSA)
Not applicable
Insecticide Resistance Classification (IRAC)
Not applicable
Fungicide Resistance Classification (FRAC)
M5
Examples of recorded resistance
-
Physical state
White crystalline solid at 99.6% purity
Related substances & organisms
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Certis
  • DuPont
  • Nufarm
  • Scotts
  • Syngenta
  • Teliton
  • Walabi
Example products using this active
  • Alto Elite
  • Amistar Opti
  • Bravo 500
  • Cherokee
  • Credo
  • Folio
  • Joules
  • Merlin
  • Midas
  • Repulse
Formulation and application details
Usually supplied as a soluble concentrate that is mixed with water and applied as a foliar spray
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
0.81
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
at 25°C
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
13800
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Ethyl acetate
-
18000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Acetone at 25°C
-
1700
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Methanol at 25°C
-
74400
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Xylene
-
Melting point (°C)
252.1
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
347
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Degradation point (°C)
347
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
8.71 X 1002 Calculated -
Log P
2.94
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderate
Bulk density (g ml⁻¹)
1.74
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Dissociation constant pKa) at 25 °C
Not applicable
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
No dissociation
Vapour pressure at 20 °C (mPa)
0.076
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
2.50 X 10-02
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
232nm = 62390, 312nm = 1116, 324nm = 1507
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Surface tension (mN m⁻¹)
71.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
at 21.5 °C 99.8%
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
Not readily biodegradable
Soil degradation (days) (aerobic)
DT₅₀ (typical)
3.53
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₅₀ (lab at 20 °C)
3.53
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₅₀ (field)
17.9
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₉₀ (lab at 20 °C)
24.7
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₉₀ (field)
59.5 - -
DT₅₀ modelling endpoint
4.29
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
geometric mean of lab studies
-
Note
EU dossier 2018: lab studies DT₅₀ range 0.256-19.0 days, DT₉₀ range 1.46-68.2 days, Soils=18; field studies DT₅₀ range 7.44-28.4 days, DT₉₀ range 24.7-94.2 days; Other sources: 30 days (DW3)
Dissipation rate RL₅₀ on plant matrix
Value
5.5
R4 R = Peer reviewed scientific publications
4 = Verified data
-
Note
Published literature RL₅₀ range 3.0-12.5 days, 8 field & undercover grown crops, various matrices, n=11
Dissipation rate RL₅₀ on and in plant matrix
Value
5.0
R4 R = Peer reviewed scientific publications
4 = Verified data
-
Note
Published literature RL₅₀ range 1.7-12.7 days, 11 field & undercover grown crops, various matrices, n=21
Aqueous photolysis DT₅₀ (days) at pH 7
Value
0.72
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Fast
Note
In sterile buffer
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
29.6
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
at 50 °C
Non-persistent
Note
Stable pH 4 to pH 7
Water-sediment DT₅₀ (days)
0.57
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Fast
Water phase only DT₅₀ (days)
0.82
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Fast
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
42.99
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Slightly mobile
Koc
2632
Notes and range
EU dossier RAR 2016; Kd range 7.7-153 mL g⁻¹, Koc range 300-6154 mL g⁻¹, Soils=9
Freundlich
Kf
27,2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Slightly mobile
Kfoc
1288
1/n
0.90
Notes and range
EU RAR 2016: Kf range 3.0-74.1 mL g⁻¹, Kfoc range 330-7000 mL g⁻¹, 1/n range 0.83-0.95, Soils=12; Literature data: Kf range 96.3-1357 mL g⁻¹, Kfoc range 13462-52585 mL g⁻¹, 1/n range 0.48-0.69, Soils=8
pH sensitivity
None
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
1.12 Calculated Low leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
2.05 X 10-02 Calculated -
Note
-
Potential for particle bound transport index
Medium Calculated -
Potential for loss via drain flow
Slightly mobile Calculated -
Key metabolites
Metabolite
Formation medium
Estimated maximum occurrence fraction
1107/2009 relevancy
4-hydroxy-2,5,6-trichloroisophtalonitrile (Ref: R182281)
Soil 0.322 Major fraction, Relevant
2-amido-3,5,6-trichlo-4-cyanobenzenesulphonic acid (Ref: R417888)
Soil 0.152 Major fraction, Relevant
3-carbamyl-2,4,5-trichlorobenzoic acid (Ref: R611965)
Soil 0.132 Major fraction, Relevant
4-amido-2,5-dichloro-6-cyano benzene-1,3-disulfonic acid (Ref: R419492)
Soil 0.124 Major fraction, Relevant
Other known metabolites
Metabolite name and reference
Aliases
Formation medium / Rate
Estimated maximum occurrence fraction
Metabolising enzymes
2,5 dichloro-4,6 dicyano-benzene-1,3 disulfonic acid (Ref: R418503) - Soil; Crop Soil=0.06 -
2-acetamido-3-[3,5-bis[(2-acetamido-3-hydroxy-3-oxo-propyl)sulfanyl]-4-chloro-2,6-dicyano-phenyl] sulfanylpropanoic acid (Ref: R613825) - Rat - -
,4-bis-amido-3,5,6-trichlorobenzenesulfonate (Ref: R471811) - Soil; Crop Soil=0.119 -
2,4,5-trichloro-3-cyano-6-hydroxy-benxamide (Ref: SYN507900) SDS66882 Soil 0.058 -
2,4,5-trichloro-3-cyano benzamid (Ref: R611966) Compound 5 Soil; Rat Soil=0.081 -
Ref: R611967 - Soil; Rat Soil=0.132 -
Ref: R611968 - Soil 0.065 -
Ref: R613636 - Soil 0.104 -
2-acetamido-3-[3-(2-acetamido-3-hydroxy-3-oxopropyl)sulfanyl-2,5-dichloro-4,6-dicyano-phenyl]sulfanylpropanoic acid (Ref: R613823) - Rat - -
ECOTOXICOLOGY
Property
Value
Source; quality score; and other information
Interpretation
Bio-concentration factor
BCF (l kg⁻¹)
100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Threshold for concern
CT₅₀ (days)
5 -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 5000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
3
B4 B = UK CRD and ACP evaluation documents / and other Defra (UK) documents (click here )
4 = Verified data
High
(ppm diet)
10 -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat Reproductive NOAEL
Moderate
Birds - Acute LD₅₀ (mg kg⁻¹)
> 2000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Coturnix japonica
Low
Birds - Short term dietary (LC₅₀/LD₅₀)
> 5200 mg kg feed⁻¹
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Coturnix japonica
-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
58.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Colinius virginianus NOAEL
Moderate
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
0.017
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Oncorhynchus mykiss
High
Fish - Chronic 21 day NOEC (mg l⁻¹)
0.0014
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Pimephales promelas
High
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
0.054
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna
High
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
0.009
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna
High
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
0.061
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Chironomus riparius
High
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
0.04
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Chironomus riparius
Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
0.29
C4 C = AGRITOX (click here )
4 = Verified data
Lemna gibba
Moderate
Non-target plants
> 4.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Avena sativa Allium cepa
Vegetative vigour, ER₅₀
as kg product ha⁻¹, product chlorothalonil 75 WG
-
> 8000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
maize onion oat radish
Seedling emergence, ER₅₀
as mL/product ha⁻¹, product chlorothalonil 500 SC
-
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
0.013
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Navicula pelliculosa
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
0.033
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Selenastrum capricornutum
Moderate
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 40
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
Moderate
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 40
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
Moderate
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Bombus terrestris
Low
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 94
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Bombus terrestris
Moderate
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other pollinators (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other pollinators (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
268.5
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Eisenia foetida
Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
50.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Eisenia foetida
Moderate
Other soil macro-organisms
Acute LC₅₀ (mg kg⁻¹)
9.1
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Folsomia candida 28d as EC20 corr
-
Chronic NOEC (mg kg⁻¹)
- - -
Other arthropod (1)
LR₅₀ g ha⁻¹
18750 48 hour
L3 L = Pesticide manuals and hard copy reference books / other sources
3 = Unverified data of known source
Aphidius rhopalosiphi
-
% Effect
- - -
Other arthropod (2)
LR₅₀ g ha⁻¹
Harmful [Dose: 900 g ha⁻¹]
AA3 AA = IOBC Database on classification of side effects to beneficial organisms, 2005
3 = Unverified data of known source
Typhlodromus pyri
-
% Effect
- - -
Soil micro-organisms
Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes

Dose: 4.8 mg kg⁻¹ soil
-
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 5000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
5000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rabbit
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
0.1
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat 4 hr (nose only)
-
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.015
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
0.05
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
0.01
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
0.003
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=100
-
Dermal penetration studies (%)
0.02-1.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
concentration dependent
-
Dangerous Substances Directive 76/464
- - -
Exposure Routes
Public
Low risk for prescribed pattern of use
Occupational
PPE/PPC recommended/advised
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
Yes, known to cause a problem
A3 A = Chromosome aberration (EFSA database)
3 = Negative
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
?Possibly, status not identified
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
Yes, known to cause a problem
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
Yes, known to cause a problem
Yes, known to cause a problem
Yes, known to cause a problem
Eye irritant Phototoxicant  
Yes, known to cause a problem
XNo, known not to cause a problem
 
General human health issues
May cause contact dermatitis
IARC group 2B carcinogen; USEPA - probable human carcinogen, formation of tumours shown to form in mice following ingestion
Endocrine issues - Activation of androgen-sensitive cells proliferation
Handling issues
Property
Value and interpretation
General
Avoid generating spray mists/dust
Not explosive or oxidising
IMDG Transport Code is usually 9
Not expected to autoignite; Not highly flammable
CLP classification 2013
Health: H317, H318, H330, H335, H351
Environment: H400, H410
EC Risk Classification
Carcinogen category 3: R40
T+ - Very toxic: R26
Xn - Harmful: R43, R41
Xi - Irritant: R37
N - Dangerous for the environment: R50, R53
EC Safety Classification
S1/2, S28, S36/37/39, S45, S60, S61
WHO Classification
U (Unlikely to present an acute hazard)
UN Number
Usually 3082
Waste disposal & packaging
Packaging Group III (minor danger)
TRANSLATIONS
Language
Name
English
chlorothalonil
French
chlorothalonil
German
Chlorthalonil
Danish
chlorothalonil
Italian
clorotalonil
Spanish
clorotalonil
Greek
chlorothalonil
Polish
chlorotalonil
Swedish
-
Hungarian
chlotalonil
Dutch
chloorthalonil

Record last updated: 18/08/2021
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242