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chlorpropham (Ref: ENT 18060)
** chlorproham ** chlor-IFC ** chlorprophame ** chlor-IPC ** CIPC ** chloropropham ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Chlorpropham is a residual herbicide and potato sprout suppressant that has EU approval for use. It is moderately soluble in water, highly volatile and moderately mobile. It is not persistent in soil but may be persistent in water systems. Chlorpropham has a low mammalian toxicity but it may bioaccumulate. It is a recognised irritant. It is moderately toxic to birds, honeybees and most aquatic organisms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chlorpropham

Description: A residual herbicide and potato sprout suppressant

Example pests controlled: Sprouting; Suckering; Annual and perennial broad-leaved weeds

Example applications: Alfalfa; Potatoes; Sugarbeet; Sweet potatoes; Tomatoes; Lettuce; Garlic; Cranberries; Blueberries; Tobacco

Efficacy & activity: Efficacy proven in field through extensive use in the EU and from field studies.

Availability status: Current

Introduction & key dates: 1951

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Netherlands/Spain
Date inclusion expires 31/07/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C10H12ClNO2
Canonical SMILES CC(C)OC(=O)NC1=CC(=CC=C1)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) CWJSHJJYOPWUGX-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H12ClNO2/c1-7(2)14-10(13)12-9-5-3-4-8(11)6-9/h3-7H,1-2H3,(H,12,13)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide, Plant growth regulator
Substance group Carbamate
Minimum active substance purity 975 g/kg
Known relevant impurities EU dossier - 3-chloroaniline @ max 0.25 g/kg
Substance origin Synthetic
Mode of action Mitosis inhibitor, absorbed predominately by roots
CAS RN 101-21-3
EC number 202-925-7
CIPAC number 43
US EPA chemical code 018301
PubChem CID 2728
Molecular mass (g mol-1) 213.66
PIN (Preferred Identification Name) propan-2-yl (3-chlorophenyl)carbamate
IUPAC name isopropyl 3-chlorocarbanilate
CAS name 1-methylethyl (3-chlorophenyl)carbamate
Other status information PAN Listed as Highly Hazardous Chemical
Relevant Environmental Water Quality Standards UK Environment Agency non-statutory standard for the protection of aquatic life: freshwater and saltwater annual average 10 ug/L, max acceptable conc 40 ug/L
Herbicide Resistance Classification (HRAC) K2
Herbicide Resistance Classification (WSSA) 23
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Lolium rigidum
Physical state White/brown crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Certis
  • Whyte Agrochemicals
  • United Phosphorus
  • Chipman
  • Universal Crop Protection
Example products using this active
  • Croptex Pewter
  • Gro-Stop 100
  • BL500
  • Warefog 25
  • Preweed
  • Furloe
UK LERAP status None
Formulation and application details Usually supplied as concentrates, diluted and applied as spray in the field or as thermal fogging formulations for application in stores.


ENVIRONMENTAL FATE

for chlorpropham

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 110 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 1000000 A5 - Heptane -
1000000 A5 - Acetone -
1000000 A5 - Xylene -
1000000 A5 - Dichloromethane -
Melting point (oC) 36 A3 -
Boiling point (oC) 256 A5 -
Degradation point (oC) 150 L2 -
Flashpoint (oC) 435 A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.75 X 1003 Calculated -
Log P 3.76 A5 High
Bulk density (g ml-1)/Specific gravity 1.18 L3 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 24 A5 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 0.047 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.54 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.96 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) 63.5 A5 at 20 degC, 98% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Considered to be readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 13.1 A5 Non-persistent
DT50 (lab at 20oC) 13.1 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 53.2 A5 -
DT90 (field) - - -
DT50 modelling endpoint 42.8 A5 worse case lab study -
Note EU 2017 dossier Lab studies DT50 range 2.8-42.8 days, DT90 range 18.8-142 days, Soils=8; EU 2003 dossier Lab studies: 2 tests DT50 22 and 27 days, DT90 73 and 90 days; Other sources: DT50 30 days (DW4)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Stable pH 4 to pH 9 at 20 degC
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable K4 -
Note Stable pH 4 to pH 9 at 20 degC
Water-sediment DT50 (days) 35.4 A5 Moderately fast
Water phase only DT50 (days) 60 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 6.79 A5 Moderately mobile
Koc 470
Notes and range EU 2016 dossier Kd range 4.31-9.99 mL/g, Koc range 244-862 mL/g, Soils=7
Freundlich Kf 6.41 A5 Moderately mobile
Kfoc 418
1/n 0.81
Notes and range EU 2017 dossier Kf range 4.0-8.7 mL/g, Kfoc range 260-774 mL/g, 1/n range 0.71-0.87, Soils=7
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-chloroaniline This metabolite may cause environmental pollution, click here for further information Soil   0.186   Major fraction; Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-chloroaniline - - - -


ECOTOXICOLOGY

for chlorpropham

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 144 A5 Threshold for concern
CT50 (days) 0.6 -
Mammals - Acute oral LD50 (mg kg-1) 4200 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) > 2000 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 5170 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 7.8 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.32 A5 Brachydanio rerio Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 3.7 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 1 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1.07 A4 Lemna minor, 7 day Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 1.65 A5 Navicula pelliculosa Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.32 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) 96.1 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) 505 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 132 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 4.8 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 4.8 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: Field rate, 100 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chlorpropham

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 4200 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 0.47 A5 Rat, 4 hr (nose only, aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.05 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.5 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) 0.5 A5 Dog, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.05 A5 -
Dermal penetration studies (%) 19-54 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Minimal risk from dietary exposure
Risk assessment indicates ARfD would not normally be execeeded
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues IARC Group 3 carcinogen
Possible spleen, bone-marrow & red blood cell toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is usually 6.1
Not explosive or oxidising
CLP classification 2013 Health: H351, H373
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
Xn - Harmful: R48/R22
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Variable with product, usually 2902 or 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for chlorpropham

Language Name
English chlorpropham
French chlorprophame
German Chlorpropham
Danish chlorpropham
Italian clorprofam
Spanish clororofam
Greek -
Slovenian klorprofam
Polish chloroprofam
Swedish klorprofam
Hungarian chlorpropham
Dutch chloorprofam

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk