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GET ADDITIONAL DATA HERE!

2,4,5-trichlorophenoxyacetic acid
** 2,4,5-T ** trioxone ** 2,4,5-T acid ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for 2,4,5-trichlorophenoxyacetic acid

Description: An obsolete herbicide used as a foliar spray to defoliate broad-leaved plants

Example pests controlled: Deciduous brush; Total vegetation; Scrub control

Example applications: Non-crop areas including rough grass pastures, farmyards, ditchbanks, industrial sites, rights of way, roadways; railways

Efficacy & activity: -

Availability status: Obsolete

Introduction & key dates: circa 1947

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database No

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C8H5Cl3O3
Canonical SMILES C1=C(C(=CC(=C1Cl)Cl)Cl)OCC(=O)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) SMYMJHWAQXWPDB-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C8H5Cl3O3/c9-4-1-6(11)7(2-5(4)10)14-3-8(12)13/h1-2H,3H2,(H,12,13)
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
2,4,5-trichlorophenoxyacetic acid - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide, Plant growth regulator
Substance group Chlorophenoxy acid
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Synthetic auxin, readily absorbed by foliage and roots and translocated throughout the plant.
CAS RN 93-76-5
EC number 202-273-3
CIPAC number -
US EPA chemical code 082001
PubChem CID 1480
Molecular mass (g mol-1) 255.48
PIN (Preferred Identification Name) -
IUPAC name (2,4,5-trichlorophenoxy)acetic acid
CAS name 2,4,5-trichlorophenoxyacetic acid
Other status information Chemical subject to PIC regulations; POP; PAN Dirty Dozen; OSPAR soc; Potential marine pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not known
Herbicide Resistance Classification (WSSA) -
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Pale yellow crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow
  • Boehringer
  • ICI Plant Protection
Example products using this active
  • BCF-Bushkiller
  • Super D Weedone
  • Esterone 245
  • Transamine
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually formulated as an emulsifiable concentrate or ULV.


ENVIRONMENTAL FATE

for 2,4,5-trichlorophenoxyacetic acid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 268 CA3 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 400 F3 - Heptane -
5000 F3 - Ethanol -
5000 F3 - Methanol -
5000 F3 - Toluene -
Melting point (oC) 156 Q3 -
Boiling point (oC) Decomposes before boiling E3 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.00 X 1004 Calculated -
Log P 4.0 CA3 - Other data Log P=0.60-3.46 (USDA) High
Bulk density (g ml-1)/Specific gravity 1.8 Q3 -
Dissociation constant (pKa) at 25oC 2.88 V3 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 0.01 CA3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.2 X 10-06 F3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 7.63 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.21 X 10+02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 350 Q3 Persistent
DT50 (lab at 20oC) 350 Q5 Persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note General literature gives DT50 around 48 weeks
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 2.48 F4 Very mobile
Koc 10
Notes and range USDA database Kd range 0.30-6.20 mL/g; Kioc range 39-186 mL/g, n=5; Other data Koc range 39-92,123 mL/g
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2,4,5-trichlorophenol Water   -   -


ECOTOXICOLOGY

for 2,4,5-trichlorophenoxyacetic acid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 500 Q3 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) - - -
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 1.3 F4 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 5.0 F4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 2.0 F3 Green algae Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for 2,4,5-trichlorophenoxyacetic acid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 500 Q3 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) - - -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational The most probable route of exposure is via inhalation and dermal exposure
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards Non-statutory WHO drinking water guideline 0.009 mg/L UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Toxic by ingestion and inhalation
May cause contact dermatitis

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
Xi - Irritant: R36/37/38
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases S24, S60, S61
WHO Classification O - Obsolete substance
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for 2,4,5-trichlorophenoxyacetic acid

Language Name
English 2,4,5-trichlorophenoxyacetic acid
French acide 2,4,5-trichloro phenoxyacetique
German (2,4,5-Trichlor-phenoxy)-essigsaeure
Danish -
Italian acido (2,4,5-tricloro-fenossi)-acetico
Spanish -
Greek -
Slovenian -
Polish kwas 2,4,5-trojchlorofenoksyoctowy
Swedish -
Hungarian -
Dutch 2,4,5-trichloor-fenoxy)-azijnzuur

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk