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chlorsulfuron (Ref: DPX 4189)
** W 4189 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chlorsulfuron

Description: A herbicide used to control most broad-leaved and some grass weeds

Example pests controlled: Velvetleaf; Shepherd's purse; Paradoxa grass; Canada thistle; Pidgweed; Henbit; Plantain; Docks; Cocklebur; Hogweed; Rough poppy

Example applications: Cereals including wheat, barley, triticale, oats; Flax

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1982

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Greece
Date inclusion expires 31/12/2019
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C12H12ClN5O4S
Canonical SMILES CC1=NC(=NC(=N1)OC)NC(=O)NS(=O)(=O)C2=CC=CC=C2Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) VJYIFXVZLXQVHO-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H12ClN5O4S/c1-7-14-10(17-12(15-7)22-2)16-11(19)18-23(20,21)9-6-4-3-5-8(9)13/h3-6H,1-2H3,(H2,14,15,16,17,18,19)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Sulfonylurea
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - 2-chlorobenzenesulfonamide, 4-methoxy-6-methyl-1,3,5-triazin-2-amine
Substance origin Synthetic
Mode of action Selective, systemic, absorbed by roots and foliage, acts by inhibiting cell division. Inhibits plant amino acid synthesis - acetohydroxyacid synthase AHAS
CAS RN 64902-72-3
EC number 265-268-5
CIPAC number 391
US EPA chemical code 118601
PubChem CID 47491
Molecular mass (g mol-1) 357.77
PIN (Preferred Identification Name) 2-chloro-N-[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzene-1-sulfonamide
IUPAC name 1-(2-chlorophenylsulfonyl)-3-(4-methoxy-6-methyl-1,3,5-triazin-2-yl)urea
CAS name 2-chloro-N-(((4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino)carbonyl)benzenesulfonamide
Other status information Potential groundwater contaminant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) B
Herbicide Resistance Classification (WSSA) 2
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Lolium perenne
Lolium rigidum
Alopecurus myosuroides
Kochia scoparia
Physical state White crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
  • King Tech
  • Pacific Agriscience Pte. Ltd
  • Nufarm
Example products using this active
  • Master
  • Trisufron
  • Lasher
  • Pilargreen
  • Glean
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a dry flowable concentrate.


ENVIRONMENTAL FATE

for chlorsulfuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 12500 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 37000 A5 - Acetone -
140000 A5 - Dichloromethane -
15000 A5 - Methanol -
2800 A5 - Toluene -
Melting point (oC) 173 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 150 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.02 X 10-01 Calculated -
Log P -0.99 A5 Low
Bulk density (g ml-1)/Specific gravity 1.48 L3 -
Dissociation constant (pKa) at 25oC 3.4 A5 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 3.07 X 10-06 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.50 X 10-11 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 4.17 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.36 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 236nm = 26399, 204nm = 31320, 236nm = 26284; [Acidic solution pH2: 202nm = 42552, 205nm = 32941, 222nm = 23968; [Basic solution pH10: 203nm = 33752, 236nm = 26399 A5 -
Surface tension (mN m-1) 73.1 A5 at 20.5oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 160 M4 Persistent
DT50 (lab at 20oC) 51.4 A5 Moderately persistent
DT50 (field) 36.2 A5 Moderately persistent
DT90 (lab at 20oC) - - -
DT90 (field) 120.3 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 10.4-187.4 days, field studies DT50 range 11.2-70.1 days, DT90 range 8.3-232.9 days; Other sources: field studies DT50 range 10-185 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 0.4 R4 -
Note Published literature RL50 range 0.2-0.5 days, ryegrass, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 18.8 A3 Slow
Note Not a major degradation route. DT50 18.8 days at pH 5 in light, 100 days discounting hydrolytic degradation
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note pH sensitive: DT50 2.23 days at pH 5, stable pH 7 to pH 9, all at 25 degC
Water-sediment DT50 (days) 26 A3 Fast
Water phase only DT50 (days) 21 A3 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 0.42 A5 Mobile
Kfoc 36.3
1/n 0.89
Notes and range EU dossier kf range 0.09-0.91 mL/g, Kfoc range 14.1-60.2 mL/g, 1/n range 0.85-0.91, Soils=4; Literature mean: Kf = 1.6 mL/g, Kfoc = 456 mL/g, 1.n = 0.78, Soils = 4
pH sensitivity Greater adsoption at lower pH. Organic Carbon content also increases adsoprtion.

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-chlorobenzenesulfonamide (Ref: IN-A4097) This metabolite may cause environmental pollution, click here for further information Soil   0.775   Major fraction, Relevant
2-amino-4-methoxy-6-methyl-1,3,5-triazine (Ref: IN-A4098) This metabolite may cause environmental pollution, click here for further information Soil   0.659   Major fraction, Relevant
N-((N-carbamoylcarbamimidoyl)carbamoyl)-2-chlorobenzenesulfonamide (Ref: IN-JJ998) This metabolite may cause environmental pollution, click here for further information Soil   0.267   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-chloro-5-(-D-glucopyranosyloxy)-benzenesulfonamide chlorsulfuron metabolite B Plant - -
2-chloro-5-(beta-D-glucopyranosyloxy)-N-[[(4-methoxy-6-methyl-1,3,5-trazi-2-yl)amino]-carbonyl]benzenesulfonamide
(Ref: IN-69182)
- Plant - -
2-chloro-5-hydroxybenzenesulfonamide
(Ref: IN-A5760)
- Animal - -
4-amino-6-methyl-1,3,5-triazin-2-ol
(Ref: IN-B5528)
Note: Highly mobile
- Soil - -
2-chlorophenylsulfonylurea
(Ref: IN-D5293)
- Soil (Anaerobic) - -
2-chloro-N-[(4-hydroxy-6-methyl-1,3,5-triazin-2-yl)carbamoyl]benzenesulfonamide
(Ref: IN-M6957)
Note: Highly mobile
- Soil; Plant - -
2-chloro-5-hydroxy-N-[[(4-methoxy-6-methyl-1,3,5-trazi-2yl)amino]-carbonyl]benzenesulfonamide
(Ref: IN-N5754)
- Plant - -
1-(4-methoxy-6-methyl-1,3,5-triazine-2-yl)urea
(Ref: IN-V7160)
Note: Highly mobile
- Soil (Photolysis) - -


ECOTOXICOLOGY

for chlorsulfuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 20 R3 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) > 100 -
Birds - Acute LD50 (mg kg-1) > 5000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 634 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 122 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 32 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 112 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 12 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 71.0 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.00035 A5 Lemna gibba High
Non-target plants 0.09 A5 Sugarbeet
Vegetative vigour, ER50
as g/ha
-
1.09 A5 Pea
Seedling emergence, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.068 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 130 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 750 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 187.5 A5 Eisenia foetida Low
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 56.25 >
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 56.25 >
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.025 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chlorsulfuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 3400 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) > 5.5 A5 Rat, 4 hr (nose or head only, aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.2 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.43 A5 Dog, SF=100 -
Dermal penetration studies (%) 100 A3 default -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible risk to bystanders
Occupational Acceptable risks for operators and other workers
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for chlorsulfuron

Language Name
English chlorsulfuron
French chlorsulfuron
German Chlorsulfuron
Danish chlorsulfuron
Italian clorsulfuron
Spanish clorsulfuron
Greek -
Slovenian klorsulfuron
Polish chlorosulfuron
Swedish klorsulfuron
Hungarian klorszulfuron
Dutch -

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk