Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

sedaxane
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for sedaxane

Description: Novel seed treatment for the control of pathogens in crops such as wheat and cotton

Example pests controlled: Rhizoctonia spp.; Fusarium patch; Head smut; Barley stripe; Ustilago spp.; Common bunt; Phoma; Dwarf bunt

Example applications: Cereals; Soybeans; OSR; Potatoes; Rice; Sugarbeet; Sunflowers; Cotton; Pulses

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2008

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur France
Date inclusion expires 31/01/2024
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: U.S.; Canada; China; Chile; Mexico; Uraguay; Australia; Argentina

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Sedaxane is a chiral molecule. The technical material is an isomeric mixture of the two cis- (0-20%)and two-trans (80-100%) isomers.
Chemical formula C18H19F2N3O
Canonical SMILES CN1C=C(C(=N1)C(F)F)C(=O)NC2=CC=CC=C2C3CC3C4CC4
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) XQJQCBDIXRIYRP-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H19F2N3O/c1-23-9-14(16(22-23)17(19)20)18(24)21-15-5-3-2-4-11(15)13-8-12(13)10-6-7-10/h2-5,9-10,12-13,17H,6-8H2,1H3,(H,21,24)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Pyrazole
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier: none declared
Substance origin Synthetic
Mode of action Broad spectrum, Succinate dehydrogenase inhibitor
CAS RN 874967-67-6
EC number -
CIPAC number 833
US EPA chemical code 129223
PubChem CID 11688533
Molecular mass (g mol-1) 331.4
PIN (Preferred Identification Name) mix of: rac-N-{2-[(1R,2S)-1,1'-bi(cyclopropan)]-2-ylphenyl}-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide and 200% rac-N-{2-[(1R,2R)-1,1'-bi(cyclopropan)]-2-ylphenyl}-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
IUPAC name mix of: trans-isomers 2'-[(1RS,2SR)-1,1'-bicycloprop-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxanilide and 200% 2 cis-isomers 2'-[(1RS,2RS)-1,1'-bicycloprop-2-yl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxanilide
CAS name N-[2-[1,1'-bicyclopropyl]-2-ylphenyl]-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
Other status information Australian APVMA No. 64098; PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 7
Examples of recorded resistance None identified
Physical state -
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta Crop Protection
Example products using this active
  • Vibrance
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Formulated as a treament for seeds.


ENVIRONMENTAL FATE

for sedaxane

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 14.0 A4 Low
Solubility - In organic solvents at 20oC (mg l-1) 410000 A5 - Acetone -
500000 A5 - Dichloromethane -
2000 A5 - Ethyl acetate -
70000 A5 - Toluene -
Melting point (oC) 121.4 A5 -
Boiling point (oC) >270 A5 -
Degradation point (oC) 270 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1003 Calculated -
Log P 3.3 A5 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 6.5 X 10-05 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 4.0 X 10-06 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.59 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.85 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral: 225nm=17233, 265nm=5996, 295nm=874
Acidic: 225nm=17423, 265nm=5683, 295nm=851
Alkaline: 225nm=17393, 265nm=5833, 195nm=955
A5 -
Surface tension (mN m-1) 48.6 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 108 A5 Persistent
DT50 (lab at 20oC) 108 A5 Persistent
DT50 (field) 100 A5 Persistent
DT90 (lab at 20oC) 361 A5 -
DT90 (field) 170 A5 -
DT50 modelling endpoint - - -
Note EU dossier DT50 lab studies range 52.4-1000 days, DT90 range 174-301 days; Field studies DT50 range 54.6-188 day, DT90 range 413->1000 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) 866 A5 Stable
Water phase only DT50 (days) 17.3 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 7.9 A5 Slightly mobile
Kfoc 534
1/n 0.87
Notes and range EU dossier Kf range 2.00-16.7 mL/g, Kfoc range 202-666 mL/g, 1/n range 0.81-0.91, soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-(difluoromethyl)-1H-pyrazole-4-carboxylic acid (Ref: CSCD465008) This metabolite may cause environmental pollution, click here for further information Soil   0.319   Major fraction, Relevant
pyrazole acid (Ref: CSAA798670) This metabolite may cause environmental pollution, click here for further information Soil   0.145   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: CSCD668094) - Water (photolysis) - -
(Ref: CSCD668095) - Water (photolysis) - -
(Ref: CSCD728931) - Soil - -
pyrazole amide
(Ref: SYN 508272)
- Soil; Water (photolysis) - -


ECOTOXICOLOGY

for sedaxane

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 1068 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 1.10 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 6.10 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants > 100 - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 1.90 A5 Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 4.0 A5 Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 27.9 A5 Aphidius rhopalosiphis -
% Effect - - -
Other arthropod (2) LR50 g ha-1 160 >
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for sedaxane

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.25 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.11 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.28 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.3 A5 Rat, SF=100 -
Dermal penetration studies (%) 0.01-0.12 A5 Concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Liver & thyroid toxicant
May cause loss of bodyweight
USEPA - probable human carcinogen
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317, H332, H351
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 2: R45
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for sedaxane

Language Name
English sedaxane
French -
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 26 June 2019
Contact: aeru@herts.ac.uk