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GET ADDITIONAL DATA HERE!
clofentezine (Ref: NC 21314)
** bisclofentazin ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for clofentezine

Description: A selective ovicidal tetrazine acaricide for use in a range of crops including fruit and ornamentals

Example pests controlled: Spidermites (eggs and adults) including the two-spotted spider mite, European red mite, McDaniel spider mite

Example applications: Fruit including apples, pears, peaches, nectarines, raspberries, strawberries, citrus; Tomatoes; Eggplant; Ornamentals including nursery stock

Efficacy & activity: Efficacy has been established via development trials and commercial use over a number of years,

Availability status: Current

Introduction & key dates: 2001

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Spain/Netherlands
Date inclusion expires 31/12/2020
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H8Cl2N4
Canonical SMILES C1=CC=C(C(=C1)C2=NN=C(N=N2)C3=CC=CC=C3Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) UXADOQPNKNTIHB-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H8Cl2N4/c15-11-7-3-1-5-9(11)13-17-19-14(20-18-13)10-6-2-4-8-12(10)16/h1-8H
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Clofentezine - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Acaricide
Substance group Tetrazine
Minimum active substance purity 780 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Specific with contact action and long residual activity
CAS RN 74115-24-5
EC number 277-728-2
CIPAC number 418
US EPA chemical code 125501
PubChem CID 73670
Molecular mass (g mol-1) 303.15
PIN (Preferred Identification Name) 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine
IUPAC name 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine
CAS name 3,6-bis(2-chlorophenyl)-1,2,4,5-tetrazine
Other status information Has been detected in Swedish air monitoring programmes.
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 10A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Panonychus ulmi
Tetranychus urticae
Physical state Magenta crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Makhteshim-Agan
  • Ypsilon SA
  • Scotts
  • FBC
Example products using this active
  • Apollo 50 SC
  • Vivaro
  • Panatac
UK LERAP status None
Formulation and application details Usually supplied as a soluble concentrate or wettable powder.


ENVIRONMENTAL FATE

for clofentezine

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.0342 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 9300 A5 - Acetone -
5670 A5 - Ethyl acetate -
490 A5 - Ethanol -
5000 A5 - Xylene -
Melting point (oC) 183 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 190 A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.23 X 1004 Calculated -
Log P 4.09 A5 High
Bulk density (g ml-1)/Specific gravity 1.52 A5 -
Dissociation constant (pKa) at 25oC - A1 -
Note: Unstable- cannot be determined
Vapour pressure at 20oC (mPa) 6.0 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 0.00536 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.36 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 8.41 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution 534.5nm = 465; [Acidic solution: 526.3nm=636; [Basic solution: 536.2=220 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability Not readily biodegradable
Soil degradation (days) (aerobic) DT50 (typical) 69.8 A5 Moderately persistent
DT50 (lab at 20oC) 69.8 A5 Moderately persistent
DT50 (field) 63.0 A5 Moderately persistent
DT90 (lab at 20oC) 426 A5 -
DT90 (field) 209.7 A5 -
DT50 modelling endpoint 67.2 A5 nomalised geometric mean -
Note EU 2018 dossier (not normalised) lab studies DT50 range 16.9-133 days, DT90 range 56->1000 days, field studies DT50 range 52.9-71.3 days, DT90 range 176-237 days, Soils=3
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 5.88 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 3.1 A5 Non-persistent
Note -
Water-sediment DT50 (days) 9.6 A5 Fast
Water phase only DT50 (days) 2.1 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 75.7 A5 Non-mobile
Kfoc 6303
1/n 0.87
Notes and range EU 2018 dossier Kf range 40.2-245.9 mL/g. Kfoc range 3753.7-17318.6 mL/g, 1/n range 079-0.97, Soils=4
pH sensitivity None

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-chlorobenzoic acid (Ref: AE-C500233) This metabolite may cause environmental pollution, click here for further information Soil   0.109   Major fraction, Relevant
hydrazide-hydrazone (Ref: AE C593600) This metabolite may cause environmental pollution, click here for further information Soil   0.130   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
di-hydro-clofentazine NC 22505 Plant - -
2-chlorobenzyl alcohol - Plant - -
4-hydroxy-clofentazine - Animal - -
3-hydroxy-clofentazine - Animal - -
5-hydroxy-clofentazine - Animal - -
2-chlorobenzonitrile
(Ref: AE F023666)
- Plants - -
2-chlorobenzamide
(Ref: AE F092117)
- Plants - -


ECOTOXICOLOGY

for clofentezine

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 248 A5 Threshold for concern
CT50 (days) 3 -
Mammals - Acute oral LD50 (mg kg-1) > 5200 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) 40 -
Birds - Acute LD50 (mg kg-1) > 6501 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 4000 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 0.01 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.007 A3 Oncorhynchus mykiss, 97 day High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 71.6 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.05 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.003 A4 Americamysis bahia as 28d NOEC High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) > 76.4 A4 Chironomus riparius, 48 hr Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.37 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 0.5 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 34.0 A5 Selenastrum capricornutum Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 84.5 A5 Apis mellifera Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 252.6 A5 Apis mellifera Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 215 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) 2.0 A5 Eisenia foetida Moderate
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) > 80 A5 Folsomia candida, 28d corr -
Other arthropod (1) LR50 g ha-1 36.2 A5 Aphidius rhopalosiphi -
% Effect 25 Mortality
Dose: 0.3 g ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 300 > Mortality
A5 Typhlodromus pyri
-
% Effect 0 Mortality
Dose: 0.3 g ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.39 mg kg-1, 28days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for clofentezine

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5200 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2100 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.2 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) None allocated A5 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.01 A5 Rat, SF=100 -
Dermal penetration studies (%) 2.1-19.9 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public No unacceptable risks to bystanders determined
Occupational Potential risk to operators and other farm workers - PPE advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.01 EU Dir 89/778/EC limit; A5 Calc MAC=0.06 μg l-1 -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D3; E0

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues May reduce blood haemoglobin levels
Possible thyroid and liver toxicant
USEPA - possible human carcinogen
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H312
Environment: H400, H412
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R52, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification III - Slightly hazardous
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for clofentezine

Language Name
English clofentezine
French clofentezine
German Clofentezin
Danish clofentezin
Italian clofentezine
Spanish clofentezin
Greek -
Slovenian klofentezin
Polish chlofentezyna
Swedish klofentezin
Hungarian klofentezin
Dutch clofentezin

Record last updated: Tuesday 03 March 2020
Contact: aeru@herts.ac.uk