(Also known as: naramycin; U-4527; isocycloheximide )
SUMMARY
Cycloheximide is an obsolete antibiotic fungicide. It is highly soluble in water and is quite mobile so there may be some risk to groundwaters depending on local conditions. It is highly toxic to birds but other ecotoxicological data is missing. It is highly toxic if ingested and may be fatal. It is also genotoxic and a reproduction/developmental toxin.
Data alerts
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate High alert: Drainflow: Mobile
Warning: Significant data are missing
Ecotoxicity High alert: Birds acute ecotoxicity: High
Warning: Significant data are missing
Human health High alert: Genotoxic
Warning: Significant data are missing
GENERAL INFORMATION
Description
An obsolete antibiotic fungicide used in horticultural mainly in combination with other fungicides
Example pests controlled
Powdery mildew; Rusts; Leafspot; Petal blight
Example applications
Ornamentals including roses, azaleas, lawn grass; Citrus; Olives
Efficacy & activity
-
Availability status
Considered obsolete but may be available in some countries
Introduction & key dates
1946, first reported
UK regulatory status
UK COPR regulatory status
Not approved
Date COPR inclusion expires
Not applicable
UK LERAP status
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Not applicable
Date EC 1107/2009 inclusion expires
Not applicable
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
No
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
Additional information
Also used in
-
Chemical structure
Isomerism
A chiral molecule; Absolute stereochemistry with 4 defined stereocentres
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242