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epichlorohydrin
** 1-epichlorohydrin ** glycerol epichlorohydrin ** chloromethyleneoxirane ** oxirane ** ECH ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Epichlorohydrin is an obsolete pesticide additive. It is highly soluble in water and highly volatile. Environmental fate data is scarce. It is very toxic to mammals and might be expected to bioaccumulate. Epichlorohydrin is also a neurotoxin and irritant. It is moderately toxic to fish and aquatic invertebrates.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information

Description: A liquid with a variety of uses as a pesticide adjuvant, solvent, stabiliser and during the maufacturer of of various synthetic materials.

Availability status: Unknown

Introduction & key dates: 1848, first described

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database No

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C3H5ClO
Canonical SMILES C1C(O1)CCl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) BRLQWZUYTZBJKN-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C3H5ClO/c4-1-3-2-5-3/h3H,1-2H2
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Other susbtance
Other constituent type Adjuvant, Stabiliser, Wood preservative
Substance group Organochlorine
Minimum active substance purity >98%
Known relevant impurities May contain chlorinated ethers, 1,4-dichlorhexane and various chlorinated propenes
Substance origin Synthetic
Mode of action Unclear but thought to damage genetic material
CAS RN 106-89-8
EC number 203-439-8
CIPAC number -
US EPA chemical code 097201
PubChem CID -
Molecular mass (g mol-1) 92.52
PIN (Preferred Identification Name) -
IUPAC name 2-(chloromethyl)oxirane
CAS name (Chloromethyl) ethylene oxide
Other status information VOC; Marine Pollutant; PAN Bad Actor chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Colourless liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically -
Example products using this active -
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


ENVIRONMENTAL FATE

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 66000 V3 High
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) -25 F3 -
Boiling point (oC) 118 F3 -
Degradation point (oC) 217 V3 -
Flashpoint (oC) 31 F3 - (closed cup) -
Octanol-water partition coefficient at pH 7, 20oC P 2.82 X 1000 Calculated -
Log P 0.45 V3 Low
Bulk density (g ml-1)/Specific gravity 1.175 F3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 1.7 X 1006 V3 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 2.4 E3 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value - - -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - - -
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) 0.035 V3 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) - - -
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note: -
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - V3 Moderately mobile
Koc 123
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
1-chloropropan-2,3-diol - Seawater - -
glycidol - Water - -
N-acetyl-S-(3-chloro-2-hydroxypropyl)-L-cysteine - Rat (urinary) - -
1-chloropropan-2,3-diol - Water - -
1,3-dichloro-2-propanol - Seawater - -


ECOTOXICOLOGY

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk F3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 40 E3 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) - - -
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 9.1 F4 Pimephales promelas Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 20.4 F4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 6.0 F3 Microcystis aeruginosa, LOEC Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 40 E3 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 515 V3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) > 250 E3 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I - -
Exposure Limits [UK LT TWA 8 HR: 0.5 ppm (1.9 mg/m3)], [STEL 15 mins: 1.5 ppm (5.8 mg/m3)] UK EA QS database, 2018 -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards UK statutory standard for drinking water quality: 0.1 ug/L
EU Directive for drinking water quality: 0.1 ug/L
Non-statutory WHO drinking water guideline 0.0004 mg/L
UK EA QS database, 2018 -
Drinking Water MAC (μg l-1) 0.1 UK EA QS database, 2018 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Poinsoning symptoms include fatigue, headache, respiratory problems
Blood, lung and liver toxicant
IARC group 2A carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is 6.1
Flammable and highly reactive
Highly volatile and vapours are toxic
Corrosive
Risk of explosion
Incompatible with strong acids, oxidising agents and many otehr chemicals
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 2: R45
T - Toxic: R23/24/25
Xn - Harmful: R43
H - Handling risks: R10, R34
EC Safety Classification Click here to view information omn the EU safety phrases S9, S44, S53
WHO Classification NL - Not listed
US EPA Classification (formulation) - -
UN Number 2996; 2023
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group II (medium danger)


TRANSLATIONS

Language Name
English epichlorohydrin
French epichlorohydrine
German Epichlorhydrin
Danish -
Italian epichloidrina
Spanish epichlorhidrina
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch epichloorhydrine

Record last updated: Monday 28 May 2018
Contact: aeru@herts.ac.uk