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cyanamide (Ref: LH 21,810A)
** amidocyanogen ** carbanonitrile ** aminoformonitrile ** cyanogenamide ** hydrogen cyanamide ** carbodiimide ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Cynanamide, sometimes referred to as hydrogen cyanamide, is a plant growth regulator than no longer has approval for use in the EU. It is highly soluble in water, is volatile and would not normally be expected to leach to groundwater. It is not persistent in soil systems but could be persistent in water under certain conditions. Cyanamide is moderately toxic to mammals, is an irritant and has a high potential for bio-concentration. It is moderately toxic to birds, fish, aquatic invertebrates, aquatic fauna, honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for cyanamide

Description: A plant growth regulator to promote bud break

Example pests controlled: Growth

Example applications: Fruit including blueberries, grapevines, apples, cherries, kiwi, peaches, nectarines; Onions, leeks, shallots, garlic & chives

Efficacy & activity: -

Availability status: Current

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Germany
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism Isomeric - the most stable cyanamide isomer is carbodiimide (HNCNH)
Chemical formula CH2N2
Canonical SMILES C(#N)N
Isomeric SMILES N#CN
International Chemical Identifier key (InChIKey) XZMCDFZZKTWFGF-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/CH2N2/c2-1-3/h2H2
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
Cyanamide - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Plant growth regulator
Substance group Unclassified
Minimum active substance purity 488 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Contact. Inhibits photosynthesis.
CAS RN 420-04-2
EC number 206-992-3
CIPAC number 685
US EPA chemical code 014002
PubChem CID 9864
Molecular mass (g mol-1) 42.04
PIN (Preferred Identification Name) cyanamide
IUPAC name cyanamide
CAS name hydrogen cyanamide
Other status information Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not known
Herbicide Resistance Classification (WSSA) -
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Colourless solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Degussa AG
  • SKW Trostberg
Example products using this active
  • Alzodef
  • Dormex
  • Hi-Cane
  • Pudpro
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a soluble concentrate that is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for cyanamide

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 560000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 210000 A5 - Acetone -
210000 A5 - Methanol -
2.4 A5 - n-Hexane -
670 A5 - Toluene -
Melting point (oC) 46.1 A5 -
Boiling point (oC) Decomposed before boiling A5 -
Degradation point (oC) 141 A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.91 X 10-01 Calculated -
Log P -0.72 A5 Low
Bulk density (g ml-1)/Specific gravity 1.23 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 510 A5 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 2.68 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.49 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.16 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 No maxima above 290nm A5 -
Surface tension (mN m-1) 72.86 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 1 A4 Non-persistent
DT50 (lab at 20oC) 1.4 A4 Non-persistent
DT50 (field) 0.9 A5 Non-persistent
DT90 (lab at 20oC) 7.0 A2 -
DT90 (field) 14 A3 -
DT50 modelling endpoint - - -
Note Lab studies DT50 range 0.7-4.56 days, DT90 range 1.94-17.7 days; field studies DT50 range 0.29-1.63 days, 2 locations, DT90 ~ 2 weeks
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 38.5 A5 Stable
Note Quicker in sunlight and under acidic conditions
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 2300 A5 Very persistent
Note pH and temperature sensitive: DT50 1200 days at pH 5 and 22 degC, 2.5 days at pH 5 and 80 degC, 810 days at pH 9 and 22 degC, 7.2 hours at pH 9 and 80 degC
Water-sediment DT50 (days) 3.7 A5 Fast
Water phase only DT50 (days) 3.3 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 0.05 A5 Very mobile
Koc 4.4
Notes and range EU dossier Kd range 0-0.092 mL.g, Koc range 0-6.81 mL/g, Soils=4
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
N-acetylcyanamide - Rat (Urinary) - -
urea - Water; Soil (Anaerobic); Sediment - -
dicyandiamide - Soil (Anaerobic) - -
guanylurea - Soil (Anaerobic) - -
guanidine - Soil (Anaerobic) - -


ECOTOXICOLOGY

for cyanamide

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 142 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 1.5 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 350 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 43.1 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 3.7 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 3.2 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.10 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 6.3 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 18.4 A5 Chironomus riparius, emergence Low
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 2.4 A5 Lemna gibba Moderate
Non-target plants 671 A5 Allium cepa
Seedling emergence, ER50
as g/ha
-
3540 A5 Lycopersicum lycopersicum
Vegetative vigour, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 6.7 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 10 A4 Moderate
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 111.6 A5 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 432.1 14 day (Other data: NOER, 14 day = 158.4 g ha-1)
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 445.6 14 day, (Other data: NOER, 14 day = 100 g ha-1)
A5 Typhlodromus pyri, protonymph
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect [Dose: 98 kg ha-1, 42 days]
Carbon mineralisation: No significant adverse effect [Dose: 100 kg ha-1, 28 days]
A5 -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for cyanamide

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 142 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 848 A5 Rabbit -
Mammals - Inhalation LC50 (mg l-1) > 1.0 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.002 A3 Dog, SF=300 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.002 A5 -
Dermal penetration studies (%) 5-100 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public Minimal risk from dietary exposure
Occupational Exposure possible via ingestion or inhalation
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E0

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Toxic if swallowed or in contact with skin
Potential for vomiting, parasympathetic hyperactivity, dyspnea, hypotension and tachycardia
USEPA - possible human carcinogen
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of dust
Avoid all contact
Reacts with acids to produce very toxic gas
Not explosive
Hygroscopic,IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H301, H312, H315, H317, H319
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R25
Xn - Harmful: R21, R43
Xi - Irritant: R36/38
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S3, S22, S36/37, S45
WHO Classification NL - Not listed
UN Number Usually 2811
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for cyanamide

Language Name
English cyanamide
French cyanamide calcique
German Cyanamid
Danish cyanamid
Italian cianamide
Spanish cyanamida; cianamida
Greek carbanonitril
Slovenian cianamid
Polish cyjanamid
Swedish -
Hungarian -
Dutch cyaanamide

Record last updated: Tuesday 30 October 2018
Contact: aeru@herts.ac.uk