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fluxapyroxad (Ref: BAS 700F)
** BAS 700 000 F ** Xemium ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fluxapyroxad

Description: A new pesticide active substance that effective controls a broad spectrum of fungal pathogens in cereals and other food crops

Example pests controlled: Botrytis mould; Powdery mildew; Early blight; Rust

Example applications: Cereals; Legumes; Oilseeds including OSR, sunflowers; Top and stone fruit; Tuber and root vegetables; Peanuts

Efficacy & activity: Wheat/Septoria=High; Wheat/Rust=Moderate; Barley/Rhynchosporium=High; Barley/Mildew=Low; Barley/Rust=Moderate, Barley/Net blotch=High

Availability status: Current

Introduction & key dates: 2011, First introduced UK; 2012, European market

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK/France
Date inclusion expires 31/12/2022
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C18H12F5N3O
Canonical SMILES CN1C=C(C(=N1)C(F)F)C(=O)NC2=CC=CC=C2C3=CC(=C(C(=C3)F)F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) SXSGXWCSHSVPGB-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H12F5N3O/c1-26-8-11(16(25-26)17(22)23)18(27)24-14-5-3-2-4-10(14)9-6-12(19)15(21)13(20)7-9/h2-8,17H,1H3,(H,24,27)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Pyrazolium
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - toluene max 1g/kg
Substance origin -
Mode of action Has proventative and curative properties and works by preventing spore gemination and infection development. Succinate DeHydrogenase Inhibitor.
CAS RN 907204-31-3
EC number -
CIPAC number 828
US EPA chemical code 138009
PubChem CID 16095400
Molecular mass (g mol-1) 381.31
PIN (Preferred Identification Name) 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)-1H-pyrazole-4-carboxamide
IUPAC name 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluorobiphenyl-2-yl)pyrazole-4-carboxamide
CAS name 3-(difluoromethyl)-1-methyl-N-(3',4',5'-trifluoro[1,1'-biphenyl]-2-yl)-1H-pyrazole-4-carboxamide
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 7
Examples of recorded resistance -
Physical state Crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF Corp
Example products using this active
  • Imbrex
  • Sercadis
  • Acceleron
  • Priaxor
  • Merivon
UK LERAP status Normally Category B
Formulation and application details Supplied as an emulsifiable concentrate and applied as a foliar spray also often used as a seed dressing.


ENVIRONMENTAL FATE

for fluxapyroxad

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 3.44 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 250000 A5 - Acetone -
123300 A5 - Ethyl acetate -
53400 A5 - Methanol -
20000 A5 - Toluene -
Melting point (oC) 156.8 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 230 A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable - -
Octanol-water partition coefficient at pH 7, 20oC P 1.35 X 1003 Calculated -
Log P 3.13 A5 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 12.58 A5 -
Note:
Vapour pressure at 20oC (mPa) 2.7 X 10-06 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.03 X 10-07 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.57 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.85 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Acidic soln: 199nm = 35913, 230nm = 24137; [Neutral soln: 203nm = 31582, 229nm = 23928; [Basic soln: 229 nm = 23473, 215nm = 23227 A5 -
Surface tension (mN m-1) 73.3 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 183 A5 Persistent
DT50 (lab at 20oC) 183 A5 Persistent
DT50 (field) - - -
DT90 (lab at 20oC) 650 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 53.0-424 days, DT90 range 229 - >1000 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) >847 A5 -
Water phase only DT50 (days) 4.4 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 8.3 A5 Slightly mobile
Kfoc 728
1/n 0.914
Notes and range EU dossier Kf range 2.5-17.9, Kfoc range 320-1101 mL/g, 1/n range 0.875-0.942, Soils=8
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (Ref: M700F001) This metabolite may cause environmental pollution, click here for further information Soil   0.139   Major fraction, Relevant
3-(difluoromethyl)-1H-pyrazole-4-carboxylic acid (Ref: M700F002) This metabolite may cause environmental pollution, click here for further information Soil   0.389   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-(difluoromethyl)-1-methyl-N-(4-hydroxy-3,4,5-trifluoro[1,1-biphenyl]-2-yl)-1H-pyrazole-4-carboxamide
(Ref: M700F005)
- Animal, Plant - -
3-(difluoromethyl)-1-methyl-N-(hydroxy-3,4,5-trifluoro[1,1-biphenyl]-2-yl)-1H-pyrazole-4-carboxamide
(Ref: M700F006)
- Animal, Plant - -
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
(Ref: M700F007)
- Surface water - -
3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide
(Ref: M700F007)
- Plant - -
3-(difluoromethyl)-N-(3,4,5-trifluoro[1,1-biphenyl]-2-yl)-1H-pyrazole4-carboxamide
(Ref: M700F008)
- Animal - -
3-(difluoromethyl)-N-(hydroxy-3,4,5-trifluoro[1,1-biphenyl]-2-yl)-1H-pyrazole-4-carboxamide
(Ref: M700F008)
- Animal, Plant - -
3-(difluoromethyl)-1-(beta-D-glucopyranosyl)-N-(3,4,5-trifluoro[1,1-biphenyl]-2-yl)-1H-pyrazole-4-carboxamide
(Ref: M700F048)
- Plant - -


ECOTOXICOLOGY

for fluxapyroxad

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 36 A5 Low potential
CT50 (days) 0.73 -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 912 mg kg-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.546 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.036 A5 Pimephales promelas Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 6.78 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.5 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 3.43 A5 Lemna gibba Moderate
Non-target plants > 2.0 A4 Unknown species
Vegetative vigour, ER50
as L product/ha (BAS 700 00 F: Conc 62.5 g/L)
-
> 2.0 A4 Unknown species
Seedling emergence, ER50
as L product/ha (BAS 700 00 F: Conc 62.5 g/L)
-
Algae - Acute 72 hour EC50, growth (mg l-1) 0.70 A5 Pseudokirchnella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 110.9 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 0.128 Mortality, as L product ha-1 (BAS 700 00 F: Conc 62.5 g/L)
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 4.70 Mortality, as L product ha-1 (BAS 700 00 F: Conc 62.5 g/L)
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.01 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fluxapyroxad

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.31 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.25 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.04 A5 Rat, SF=100 -
Dermal penetration studies (%) 0.16-8 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Moderate to low risk for bystanders suggested
Occupational PPE/PPC advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Possible liver, prostrate and thyroid toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Non-oxidising and non-explosive
CLP classification 2013 Health: H317, H319, H332, H351, H361d
Environment: H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S13, S20/21, S36/37, S46, S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) III or IV - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for fluxapyroxad

Language Name
English fluxapyroxad
French fluxapyroxade
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk