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demeton-S-methyl
** methyl-mercaptophos-teolovy ** methyl demeton ** mercapthphos ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Demeton-S-methyl is an insecticide not approved for use in the EU. It is highly soluble in water, volatile and, based on its physico-chemical data, it is not expected to leach to groundwater. It is not persistent in soil systems. Demeton-S-methyl is highly toxic to mammals, a cholinesterase inhibitor, a neurotoxin and a recognised irritant. It is highly toxic to birds, aquatic invertebrates and honey bees and moderately toxic to most other species including fish and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for demeton-S-methyl

Description: An insecticide used to control aphids and other sucking insects on a range of crops

Example pests controlled: Aphids including woolly aphids, citrus aphids, Russian aphids; Sawflies; Bryobia mites; Lacebugs

Example applications: Vegetables including beans, peas, brassicas, peppers, aubergines, onions; Fruit including olives, peaches, plums, apricots; Tomatoes; Cotton; Peanuts; Wheat; Maize; Sorghum

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: 1957

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism The methyl ester of the S-form of isomeric demeton
Chemical formula C6H15O3PS2
Canonical SMILES CCSCCSP(=O)(OC)OC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) WEBQKRLKWNIYKK-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C6H15O3PS2/c1-4-11-5-6-12-10(7,8-2)9-3/h4-6H2,1-3H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Acaricide
Substance group Organophosphate
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 919-86-8
EC number 213-052-6
CIPAC number 47
US EPA chemical code -
PubChem CID 13526
Molecular mass (g mol-1) 230.29
PIN (Preferred Identification Name) S-[2-(ethylsulfanyl)ethyl] O,O-dimethyl phosphorothioate
IUPAC name S-2-ethylthioethyl O,O-dimethyl phosphorothioate
CAS name S-(2-(ethylthio)ethyl) O,O-dimethyl phosphorothioate
Other status information Pan Bad Actor
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Aphis gossypii
Panonychus ulmi
Tetranychus urticae
Tetranychus viennensis
Aculus cornutus
Aphis craccivora
many others
Physical state Yellow oil
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • Doo Yang Industrial Co. Ltd.
Example products using this active
  • Metasystox
  • Duratox
  • DSM
  • Demeton EC
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an emulsifiable concentrate.


ENVIRONMENTAL FATE

for demeton-S-methyl

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 22000 L3 High
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) - - -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 2.09 X 1001 Calculated -
Log P 1.32 G4 Low
Bulk density (g ml-1)/Specific gravity 1.21 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 40 L3 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 4.19 X 10-04 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.88 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.95 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 2.7 K4 Non-persistent
DT50 (lab at 20oC) 2.7 K4 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note: -
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 3.0 R3 -
Note Mango fruit, n=1
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 56 L3 Moderately persistent
Note pH sensitive: DT50 63 days at pH 4, 8 days at pH 9 all at 22 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - W3 Moderately mobile
Koc 90
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
demeton-S-methyl sulfone Animal   -   -


ECOTOXICOLOGY

for demeton-S-methyl

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 0.5 R3 (LogP < 3) Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 40 F4 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) 1 -
Birds - Acute LD50 (mg kg-1) 44 L3 Coturnix japonica High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 6.4 L3 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 0.023 L3 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 22.1 L3 Scenedemus subspicatus Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) 10 Q2 Unknown species Low
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 2.6 F3 Apis mellifera, 24hr Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 0.19 K4 Apis mellifera High
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 2.68 R4 Bombus terrestris, 48 hr Moderate
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) 0.076 R4 Megachile rotundata High
Mode of exposure Contact
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 250 L3 Eisenia foetida Moderate
Earthworms - Chronic NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms Acute LC50 (mg kg-1) - - -
Chronic NOEC (mg kg-1) - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmless AB1 Typhlodromus pyri -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for demeton-S-methyl

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 40 F4 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 30 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.13 L3 Rat, (aerosol) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0003 L3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E1

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Combustible
CLP classification 2013 Health: H301, H311
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R24/25
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S28, S36/37, S45, S61
WHO Classification Ib - Highly hazardous
UN Number Usually 3018
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for demeton-S-methyl

Language Name
English demeton-S-methyl
French demeton-S-methyle
German Demeton-S-methyl
Danish demeton-S-methyl
Italian demeton-s-metil
Spanish demeton-S-metil
Greek demeton-S-methyl
Slovenian demeton-S-metil
Polish demeton-S-metylowy
Swedish -
Hungarian -
Dutch demeton-S-methyl

Record last updated: Tuesday 26 November 2019
Contact: aeru@herts.ac.uk