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diafenthiuron (Ref: CGA 106630)
** CG 167 ** CGA 106630 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Diafenthiuron is an insecticide and acaricide without regulatory approval for use in the EU. It has a low aqueous solubility but is readily soluble in many organic solvents. It is volatile and, based on its chemical properties, it is unlikely to leach to groundwater. It is not persistent in most soil systems but may be very persistent in aquatic systems. It has a low mammalian toxicity but is moderate to highly toxic for most biodiversity including aquatic life, bees and worms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for diafenthiuron

Description: An insecticide and acaricide effective against phytophagous mites and other sucking pests

Example pests controlled: Aphids; Whiteflies; Spidermites; Diamondback moth; thrips; Jassids

Example applications: Cotton; Fruit trees; Ornamentals; Soybeans

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1988, first reported; 1990, first marketed

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Asia Pacific, Latin America

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C23H32N2OS
Canonical SMILES CC(C)C1=CC(=CC(=C1NC(=S)NC(C)(C)C)C(C)C)OC2=CC=CC=C2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) WOWBFOBYOAGEEA-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C23H32N2OS/c1-15(2)19-13-18(26-17-11-9-8-10-12-17)14-20(16(3)4)21(19)24-22(27)25-23(5,6)7/h8-16H,1-7H3,(H2,24,25,27)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Acaricide, Miticide
Substance group Thiourea
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Broad spectrum, contact and stomach action with some ovicidal activity, acts by inhibiting oxidative phosphorylation
CAS RN 80060-09-9
EC number -
CIPAC number 8097
US EPA chemical code -
PubChem CID 3034380
Molecular mass (g mol-1) 384.58
PIN (Preferred Identification Name) N-tert-butyl-N'-[2,6-di(propan-2-yl)-4-phenoxyphenyl]carbonothioic diamide
IUPAC name 1-tert-butyl-3-(2,6-diisopropyl-4-phenoxyphenyl)thiourea
CAS name N-(2,6-bis(1-methylethyl)-4-phenoxyphenyl)-N'-(1,1-dimethylethyl)thiourea
Other status information PAN Listed as Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 12A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance None recorded
Physical state White powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta
  • Nanjing Essence Fine-Chemicals Co. Ltd
Example products using this active
  • Ferna
  • Pegasus
  • Polo
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often supplied as suspension concentrates or wettable powders.


ENVIRONMENTAL FATE

for diafenthiuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.06 L3 Low
Solubility - In organic solvents at 20oC (mg l-1) 43000 L3 - Ethanol -
320000 L3 - Acetone -
33000 L3 - Toluene -
9600 L3 - n-Hexane -
Melting point (oC) 146 F4 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable - -
Octanol-water partition coefficient at pH 7, 20oC P 5.75 X 1005 Calculated -
Log P 5.76 Z3 High
Bulk density (g ml-1)/Specific gravity 1.09 Z3 -
Dissociation constant (pKa) at 25oC Not applicable Z3 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.002 F4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.28 X 10-02 F4 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.19 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 0.5 Click here to see a warning relating to modelling and this active substance L3 Non-persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data suggests DT50 1 hour to 1.5 days (Z3)
Dissipation rate RL50 on plant matrix Value 3.1 R3 -
Note Chinese cabbage leaves, undercover, n=1
Dissipation rate RL50 on and in plant matrix Value 3.0 R4 -
Note Published literature RL50 range 2.4-4.3 days, 3.0 field & undercover grown crops, various matrices, n=3
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note Stable to UV light
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable L3 -
Note pH variable: 4 years at pH 5, 451 days at pH 7, 796 days at pH 9, all at 20 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - Q2 Non-mobile
Koc 43546
Notes and range Estimated
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for diafenthiuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 2068 L3 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - L3 Rat -
(ppm diet) 4 -
Birds - Acute LD50 (mg kg-1) 1500 L3 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.0007 L3 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 0.5 L3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 1.5 L3 Moderate
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 1000 Z2 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Moderately harmful Dose: 500 g ha-1
AA3 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect Harmless Dose: 500 g ha-1
AA3 Typhlodromus pyri
-
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for diafenthiuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2068 L3 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.558 L3 Rat, 4 hr -
Other Mammal toxicity endpoints Acute percutaneous LD50 > 2000 mg kg-1 E4 Rat -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.003 L3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational PPC/PPE required to mitigate exposure risks
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Toxic if swallowed or inhaled
Probable kidney toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Non-corrosive
CLP classification 2013 Health: H373, H370, H330, H319, H302
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R23
Xn - Harmful: R48/21/22
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for diafenthiuron

Language Name
English diafenthiuron
French diafenthiuron
German Diafenthiuron
Danish diafenthiuron
Italian diafentiuron
Spanish diafentiuron
Greek -
Slovenian diafentiuron
Polish diafentiuron
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 22 February 2019
Contact: aeru@herts.ac.uk