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diethofencarb (Ref: S 1605)
** isopropyl-3,4-diethoxycarbanilate ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Diethofencarb is a carbamate fungicide that is approved for use in the EU. It has a low aqueous solubility and is volatile. Based on its chemical properties, it is not expected to leach to groundwater. It is not persistent in soils but can be in water in some circumstances. It has a low mammalian toxicity. However, exposure may damage reproduction and/or development. Diethofencarb is also a recognised irritant. It is moderately toxic to most aquatic organisms, honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for diethofencarb

Description: A carbamate fungicide with strong activity against botrytis.

Example pests controlled: Botrytis cinerea and benzimidazole-resistant strains of Botryis spp.

Example applications: Apples; Pears; Ornamentals

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1986

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur France
Date inclusion expires 31/05/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C14H21NO4
Canonical SMILES CCOC1=C(C=C(C=C1)NC(=O)OC(C)C)OCC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) LNJNFVJKDJYTEU-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H21NO4/c1-5-17-12-8-7-11(9-13(12)18-6-2)15-14(16)19-10(3)4/h7-10H,5-6H2,1-4H3,(H,15,16)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Carbamate
Minimum active substance purity 970 g/kg
Known relevant impurities EU dossier - toluene <1 g/kg
Substance origin Synthetic
Mode of action Systemic with protective and curative action. Inhibition of mitosis and cell division (Beta-tubulin assembly in mitosis).
CAS RN 87130-20-9
EC number 403-870-3
CIPAC number 513
US EPA chemical code -
PubChem CID 91742
Molecular mass (g mol-1) 267.32
PIN (Preferred Identification Name) propan-2-yl (3,4-diethoxyphenyl)carbamate
IUPAC name isopropyl 3,4-diethoxycarbanilate
CAS name 1-methylethyl (3,4-diethoxyphenyl)carbamate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 10
Examples of recorded resistance -
Physical state White to pale pink crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically -
Example products using this active
  • Sumico
  • Powmyl 25WP
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually as a wettable powder that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for diethofencarb

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 27.64 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 207400 A5 - Acetone -
106100 A5 - Methanol -
29900 A5 - Xylene -
140400 A5 - Ethyl acetate -
Melting point (oC) 98.3 A5 -
Boiling point (oC) 272 A5 -
Degradation point (oC) Not highly flammable A5 -
Flashpoint (oC) 140 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 7.76 X 1002 Calculated -
Log P 2.89 A5 Moderate
Bulk density (g ml-1)/Specific gravity 1.19 L3 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 9.94 X 10-03 A5 - at 25 degC Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 9.12 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.09 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.49 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Acid media: 207.7nm = 39000, 243.1nm = 16000, 286.8nm = 3600; [Neutral media: 207.1nm = 39000, 243.3nm = 15000, 287nm = 3500; [Basic media: 207.3nm = 39000, 243.1nm = 16000, 286.8nm = 3600 A5 -
Surface tension (mN m-1) 68.8 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 5.4 K4 Non-persistent
DT50 (lab at 20oC) 4.6 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 32.8 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 1.0-121.3 days; General literature DT50: 1.5-9.2 days (R3)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 3.1 R3 -
Note Spring onion, whole plant, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 17 A5 Slow
Note Natural summer sunlight
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable at pH 3-9 at 25 degC
Water-sediment DT50 (days) 24.9 A5 Fast
Water phase only DT50 (days) 9.8 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 5.7 A5 Moderately mobile
Kfoc 224
1/n 0.84
Notes and range EU dossier Kf 0.02-15.98 mL/g, Kfoc range 33-505 mL/g, 1/n range 0.410-0.953, Soils=14
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
isopropyl 4,5-diethoxy-2-nitrocarbanilate This metabolite may cause environmental pollution, click here for further information Soil   0.289   Major fraction; Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
isopropyl 3-ethoxy-4-hydroxycarbanilate 4-OH-DFC Animal; Soil; Surface water; Sediment; Groundwater - -
isopropylcarbamate IPC Surface water; Sediment - -


ECOTOXICOLOGY

for diethofencarb

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 330 F4 Whole fish Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 1629 mg kg-1 BW/day A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) > 10 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.072 A5 Oncorhynchus mykiss, Growth Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 23 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.032 A5 Daphnia magna, Reproduction Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 3.8 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 9.1 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 100 A5 Low
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 1500 >, Mortality
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 7.2 Mortality
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 7 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for diethofencarb

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.05 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.43 A4 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.50 A4 Dog, SF=100 -
Dermal penetration studies (%) 0.7-6.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public No unacceptable risks identified
Occupational No unacceptable risks identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B3; C3; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Liver, kidney and bladder toxicant
Causes serious eye irritation
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H319
EC Risk Classification Click here to view information omn the EU risk phrases Xi - Irritant: R36
EC Safety Classification Click here to view information omn the EU safety phrases S26
WHO Classification U - Unlikely to present an acute hazard
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for diethofencarb

Language Name
English diethofencarb
French diethofencarbe
German Diethofencarb
Danish diethofencarb
Italian dietofencarb
Spanish dietofencarb
Greek -
Slovenian dietofenkarb
Polish dietofenkarb
Swedish -
Hungarian -
Dutch diethofencarb

Record last updated: Friday 28 June 2019
Contact: aeru@herts.ac.uk