Nornicotine
Last updated: 24/01/2023
(Also known as: dimethylnicotine)
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Plant alkaloid related to nicotine (metabolite) that can be used to control various soft-bodied insect pests
Aphids including Green peach aphid; Thrips; Mealy bugs
Beans; Spinach; Turnips; Apples
-
Current
-
Not approved
Not applicable
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Not applicable
Not applicable
No
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
ISIceland
NONorway
 
 
 
 
 
 
 
 
 
Nornicotine is a chiral molecule with Absolute stereochemistry
C₉H₁₂N₂
C1CC(NC1)C2=CN=CC=C2
C1C[C@H](NC1)C2=CN=CC=C2
MYKUKUCHPMASKF-VIFPVBQESA-N
InChI=1S/C9H12N2/c1-3-8(7-10-5-1)9-4-2-6-11-9/h1,3,5,7,9,11H,2,4,6H2/t9-/m0/s1
Yes
Insecticide, Metabolite
Soil
Plant derived substance substance
-
-
Natural
Broad spectrum and fast acting. Mainly respiratory action but some contact and stomach activity
494-97-3
621-530-4
None allocated
-
412
No data found
148.20
3-[(2S)-pyrrolidin-2-yl]pyridine
3-[(2S)-pyrrolidin-2-yl]pyridine
3-(2S)-2-pyrrolidinylpyridine
-
-
Not applicable
Not applicable
4B
Not applicable
-
Yellow coloured viscous liquid with amine type odour
nicotine
Soil
-
Minor fraction
50
Moderate
-
-
-
-
-
-
270
-
-
-
-
213.8
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
-
1.48 X 1000
Calculated
-
0.17
Low
-
-
-
-
-
-
1.074
-
5.25
-
-
-
-
-
-
-
-
Does not absort at wavelengths >290nm
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
4.2
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Mustard leaves, n=1
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Soil adsorption and mobility
-
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Moderately mobile
250
Literature estimates of Koc range 14-500 mL g⁻¹
-
-
-
-
-
-
-
-
-
-
Cannot be calculated
-
-
-
-
-
-
-
-
-
Low risk
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Based on LogP < 3
Low risk
-
-
None
Terrestrial ecotoxicology
> 21.7
Mouse
High
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
> 10
Eisenia foetida
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
> 21.7
Mouse
High
-
-
-
-
-
-
Intravenous LD₅₀ = 3.41 mg kg⁻¹
Mouse
-
Intraperitoneal LD₅₀ = 14.66 mg kg⁻¹
Mouse
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
EU MRL pesticide database 
-
-
-
-
-
-
-
-
-
-
Carcinogen
Endocrine disruptor
?Possibly, status not identified
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
XNo, known not to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Very toxic by inhalation and ingestion - may be fatal Nicotinic exposure may cause various adverse health effects
Hygroscopic IMDG Transport Code is usually 6.1
-
Not listed
3140
Packaging Group III (minor danger)
nornicotine
nornicotine
-
-
-
-
-
-
-
-
-
-
Record last updated:
24/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242