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disulfoton (Ref: ENT 23347)
** M 74 ** ethylthiodemeton ** thiodemeton ** dithiodemeton ** dithiosystox ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for disulfoton

Description: An organophosphate aphicide and insecticide used to sucking insects on agricultural crops

Example pests controlled: Aphids; Thrips; Mealybugs; Spider mites; Leaf miners; Leaf hoppers; Beet flies

Example applications: Cotton; Tobacco; Sugarbeet; Cole crops; Peanuts; Corn; Wheat; Ornamentals; Cereals grains; Potatoes

Efficacy & activity: Disulfoton is an organothiophosphate insecticide and acaricide that is not approved for use in the EU. It has a low aqueous solubility, is moderately volatile and, based on its chemical properties it would not normally be expected to leach to groundwater. It can be persistent in some soil systems but would not normally be persistent in water bodies. It is highly toxic to mammals, a cholinesterase inhibitor, a neurotoxicant and there are some concerns regarding its carcinogenity. It is moderately or highly toxic to most fauna.

Availability status: Current

Introduction & key dates: 1956

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C8H19O2PS3
Canonical SMILES CCOP(=S)(OCC)SCCSCC
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) SYJFEGQWDCRVNX-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C8H19O2PS3/c1-4-9-11(12,10-5-2)14-8-7-13-6-3/h4-8H2,1-3H3
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Acaricide
Substance group Organophosphate
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Systemic absorbed via roots. Acetylcholinesterase (AChE) inhibitor.
CAS RN 298-04-4
EC number 206-054-3
CIPAC number 152
US EPA chemical code 032501
PubChem CID 3118
Molecular mass (g mol-1) 274.40
PIN (Preferred Identification Name) O,O-diethyl S-[2-(ethylsulfanyl)ethyl] phosphorodithioate
IUPAC name O,O-diethyl S-2-ethylthioethyl phosphorodithioate
CAS name O,O-diethyl S-[2-(ethylthio)ethyl] phosphorodithioate
Other status information Potential groundwater contaminant; Marine Pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Myzus persicae
Phorodon humuli
Rhizoglyphus robini
Tetranychus kanzawai
Leucoptera coffeella
many others
Physical state Yellow oil
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer
  • Sandoz
  • Mobay
Example products using this active
  • Disyston
  • Frumin AL
  • Solvirex
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available in a variety of formulations includign emulsifiable concentrates, dry seed dressings and granules.


ENVIRONMENTAL FATE

for disulfoton

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 25 F4 Low
Solubility - In organic solvents at 20oC (mg l-1) Miscible L3 - n-Hexane -
Miscible L3 - Dichloromethane -
Miscible L3 - Isopropanol -
Miscible L3 - Toluene -
Melting point (oC) -25 L3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) 133 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 8.91 X 1003 Calculated -
Log P 3.95 H4 High
Bulk density (g ml-1)/Specific gravity 1.14 F4 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 7.2 H4 Moderately volatile
Henry's law constant at 25oC (Pa m3 mol-1) 1.60 X 10-01 H4 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.26 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.29 X 10-04 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 30 M4 Moderately persistent
DT50 (lab at 20oC) 2 M4 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 4 P2 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 300 P3 Persistent
Note -
Water-sediment DT50 (days) 15 Q3 Fast
Water phase only DT50 (days) 15 Q3 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - H3 Slightly mobile
Koc 1345
Notes and range Other sources: 600 mL/g (DW3)
Freundlich Kf 39.5 Q2 -
Kfoc -
1/n 1.09
Notes and range General literature data: Kf range 15.5-24.3 mL/g, mean of 8 values for 2 loam soils.
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
disulfoton sulfoxide Soil   0.05   -


ECOTOXICOLOGY

for disulfoton

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 460 F4 Whole fish Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 2.6 F4 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) 1 -
Birds - Acute LD50 (mg kg-1) 39 L3 Colinus virginianus High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.039 L3 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.22 F3 Oncorhynchus mykiss, 35 day LOEC Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.013 L3 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.00004 P3 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.1 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.036 F2 Unknown species Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.01 Q1 Unknown species Moderate
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 0.96 F4 Apis mellifera High
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 4.1 F3 Apis mellifera Moderate
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) > 1.0 R3 Bombus spp. Moderate
Literature values range 1.0-6.0 ug/bee
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 180 Q3 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for disulfoton

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2.6 F4 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 3.6 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.015 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0003 JMPR 1996 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.003 JMPR 1996 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Routes Public -
Occupational Rapidly absorbed through the skin
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A3; B0; C0; D0; E2

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

-

-

General human health issues No further information available
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Health: H300, H310
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R27/28
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S28, S36/37, S45, S60, S61
WHO Classification Ia - Extremely hazardous
UN Number 3018
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for disulfoton

Language Name
English disulfoton
French disulfoton
German Disulfoton
Danish disulfoton
Italian disulfoton
Spanish disulfoton
Greek disulfoton
Slovenian disulfoton
Polish disulfoton
Swedish -
Hungarian -
Dutch disulfoton

Record last updated: Tuesday 04 June 2019
Contact: aeru@herts.ac.uk