Disulfoton (Ref: ENT 23347)
Last updated: 19/03/2022
(Also known as: M 74; ethylhiometon; thiodemeton; dithiodemeton; dithiosystox)
Disulfoton is an organothiophosphate insecticide and acaricide that is not approved for use in the EU. It has a low aqueous solubility, is moderately volatile and, based on its chemical properties it would not normally be expected to leach to groundwater. It can be persistent in some soil systems but would not normally be persistent in water bodies. It is highly toxic to mammals, a cholinesterase inhibitor, a neurotoxicant and there are some concerns regarding its carcinogenity. It is moderately or highly toxic to most fauna.
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
An organophosphate aphicide and insecticide used to sucking insects on agricultural crops
Aphids; Thrips; Mealybugs; Spider mites; Leaf miners; Leaf hoppers; Beet flies
Cotton; Tobacco; Sugarbeet; Cole crops; Peanuts; Corn; Wheat; Ornamentals; Cereals grains; Potatoes
Current
1956
Not approved
Expired
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Expired
Not applicable
Yes
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
None
C₈H₁₉O₂PS₃
CCOP(=S)(OCC)SCCSCC
No data
SYJFEGQWDCRVNX-UHFFFAOYSA-N
InChI=1S/C8H19O2PS3/c1-4-9-11(12,10-5-2)14-8-7-13-6-3/h4-8H2,1-3H3
Yes
Insecticide, Acaricide
Organophosphate insecticide; Organophosphate acaricide; Organothiophosphate insecticide; Organothiophosphate acaricide
-
-
Synthetic
Systemic absorbed via roots. Acetylcholinesterase (AChE) inhibitor.
298-04-4
206-054-3
152
032501
3118
274.40
O,O-diethyl S-[2-(ethylsulfanyl)ethyl] phosphorodithioate
O,O-diethyl S-2-ethylthioethyl phosphorodithioate
O,O-diethyl S-[2-(ethylthio)ethyl] phosphorodithioate
Potential groundwater contaminant; Marine Pollutant
-
Not applicable
Not applicable
1B
Not applicable
Myzus persicae , Phorodon humuli , Rhizoglyphus robini , Tetranychus kanzawai , Leucoptera coffeella , many others
Yellow oil
Disyston Frumin AL Solvirex
Available in a variety of formulations includign emulsifiable concentrates, dry seed dressings and granules
25
Low
Miscible
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
n-Hexane
-
Miscible
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Dichloromethane
-
Miscible
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Isopropanol
-
Miscible
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Toluene
-
-25
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
-
-
-
-
-
-
133
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
8.91 X 1003
Calculated
-
3.95
High
1.14
-
-
-
-
-
7.2
Moderately volatile
1.60 X 10-01
Moderately volatile
-
-
-
-
-
-
-
30
Moderately persistent
2
Non-persistent
-
-
-
-
-
-
-
-
-
-
-
-
Best available data
-
-
-
-
-
-
-
-
4
P2 P = Other governments and regulators 2 = Unverified data of unknown source
Moderately fast
-
300
P3 P = Other governments and regulators 3 = Unverified data of known source
Persistent
-
15
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Fast
15
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Slow
Soil adsorption and mobility
-
Slightly mobile
1345
Other sources: 600 mL g⁻¹ (DW3)
39.5
Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source
-
-
1.09
General literature data: Kf range 15.5-24.3 mL g⁻¹, mean of 8 values for 2 loam soils.
-
0.26
Calculated
Low leachability
6.29 X 10-04
Calculated
-
-
Medium
Calculated
-
Slightly mobile
Calculated
-
460
Whole fish
Threshold for concern
Not available
-
Terrestrial ecotoxicology
2.6
Rat
High
-
L2 L = Pesticide manuals and hard copy reference books / other sources 2 = Unverified data of unknown source
Rat 2 year
-
1
-
-
-
-
39
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Colinus virginianus
High
-
-
-
-
-
-
180
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0.96
Apis mellifera
High
4.1
Apis mellifera
Moderate
-
-
-
-
-
-
> 1.0
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Bombus spp.
Moderate
Literature values range 1.0-6.0 µg bee⁻¹
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
0.039
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Lepomis macrochirus
High
0.22
Oncorhynchus mykiss 35 day LOEC
Moderate
0.013
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Daphnia magna
High
0.00004
P3 P = Other governments and regulators 3 = Unverified data of known source
Daphnia magna
High
0.1
Americamysis bahia
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
0.036
Unknown species
Moderate
0.01
Q1 Q = Miscellaneous internet resources 1 = Estimated data with little or no verification
Unknown species
Moderate
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
2.6
Rat
High
3.6
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
0.015
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
-
-
-
0.0003
JMPR 1996
-
0.003
JMPR 1996
-
-
-
-
-
-
-
-
-
-
List I; List II
-
-
-
Rapidly absorbed through the skin
EU MRL pesticide database 
-
-
-
-
-
-
-
-
-
-
Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database) 3 = Negative
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E2 E = Unspecified genotoxicity type (miscellaneous data source) 2 = Mixed/ambiguous results
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
No data found
No data found
Eye irritant
Phototoxicant
 
No data found
No data found
 
No further information available
No information available
Health: H300, H310 Environment: H400, H410
Ia (Extremely hazardous)
3018
-
disulfoton
disulfoton
Disulfoton
disulfoton
disulfoton
disulfoton
disulfoton
disulfoton
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-
disulfoton
Record last updated:
19/03/2022
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242