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halauxifen-methyl (Ref: DE-729)
** XDE-729 ** XR-729 ** halauxiphen-methyl ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for halauxifen-methyl

Description: A novel picolinic acid herbicide for use on cereals, rice and other crops the control of broad-leaved weeds

Example pests controlled: Broad-leaved weeds

Example applications: Wheat, barley

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: 2014, Introduction

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur United Kingdom/France
Date inclusion expires 05/08/2025
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Pending Canada & USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H11Cl2FN2O3
Canonical SMILES COC1=C(C=CC(=C1F)C2=NC(=C(C(=C2)N)Cl)C(=O)OC)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) KDHKOPYYWOHESS-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H11Cl2FN2O3/c1-21-13-7(15)4-3-6(11(13)17)9-5-8(18)10(16)12(19-9)14(20)22-2/h3-5H,1-2H3,(H2,18,19)
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Picolinic acid
Minimum active substance purity 930 g/kg
Known relevant impurities -
Substance origin Synthetic
Mode of action Synthetic auxin.
CAS RN 943831-98-9
EC number -
CIPAC number 970.201
US EPA chemical code -
PubChem CID 16656802
Molecular mass (g mol-1) 345.16
PIN (Preferred Identification Name) methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate
IUPAC name methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate
CAS name methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)-2-pyridinecarboxylate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not known
Herbicide Resistance Classification (WSSA) -
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White powdery solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow Agrosciences
Example products using this active
  • Arylex Active
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an emuslifiable concentrate to use as a broadcasted foliar spray.


ENVIRONMENTAL FATE

for halauxifen-methyl

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 1830 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 38.1 A5 - Methanol -
250 A5 - Acetone -
129 A5 - Ethyl acetate -
9.83 A5 - n-Octanol -
Melting point (oC) 145.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 222 A5 -
Flashpoint (oC) Not expected to self-ignite; Not highly flammable. - -
Octanol-water partition coefficient at pH 7, 20oC P 5.75 X 1003 Calculated -
Log P 3.76 A5 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 2.84 A5 -
Note:
Vapour pressure at 20oC (mPa) 1.5 X 10-05 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.11 X 10-06 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.11 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 3.12 X 10-04 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral: 212nm=16401, 249nm=18956
Acidic: 215nm=22496, 256nm=13770
Basic: 212nm=19023, 247nm=21979
A5 -
Surface tension (mN m-1) 72.5 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 1.3 A5 Non-persistent
DT50 (lab at 20oC) 1.3 A5 Non-persistent
DT50 (field) 43 A5 Moderately persistent
DT90 (lab at 20oC) 7.2 A5 -
DT90 (field) 144 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 0.9-2.0, DT90 range 3.0-16.3; Field studies DT50 range 2.1-43 days, DT90 range 49-144 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 0.001 A5 Fast
Note Very rapid - 4-7 minutes
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 155 A5 - @27 DegC, pH 7 Persistent
Note Highly variable with pH and temperature.
Water-sediment DT50 (days) 1.8 A5 Fast
Water phase only DT50 (days) 1.8 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 72.7 A5 Slightly mobile
Koc 1417
Notes and range EU dossier Kd range 13-340 mL/g, Koc range 473-2659 mL/g, soils=7
Freundlich Kf 18 A5 Slightly mobile
Kfoc 995
1/n 0.87
Notes and range EU dossier kf range 8-310 mL/g, Kfoc range 190-1812 mL/g, 1/n range 0.76-0.98, soils=7
pH sensitivity Weak

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
halauxifen (Ref: X11393729) This metabolite may cause environmental pollution, click here for further information Soil   0.727   Major fraction, Relevant
4-amino-3-chloro-6-(4-chloro-2-fluoro-3-hydroxyphenyl)pyridine-2-carboxylic acid (Ref: X11449757) This metabolite may cause environmental pollution, click here for further information Soil   0.174   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-hydroxyphenyl)pyridine-2-carboxylate
(Ref: X11406790)
- Surface water; Soil; Sediment - -


ECOTOXICOLOGY

for halauxifen-methyl

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 217 A5 Threshold for concern
CT50 (days) 1.6 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 2.01 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.0115 A4 Cyprinodon variegates, 28 days Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 2.21 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.144 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) > 1.30 A5 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 1.26 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 89.3 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 2.13 A5 Lemna gibba Moderate
Non-target plants 0.4 A5 Soybean, Carrot
Vegetative vigour, ER50
as g/ha
-
0.417 A5 Soybean, Carrot
Seedling emergence, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) > 0.855 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 98.1 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 108 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 5.0 A5 Eisenia foetida, corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 1814 >
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 1462 A5 Aphidius rhopalosiphi -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.05 mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for halauxifen-methyl

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class Low (class I) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.058 A5 Rabbit, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.058 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.058 A5 Rabbit, SF=100 -
Dermal penetration studies (%) 1-4% A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Possible liver, kideny and bladder toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H317, H319, H335
Environment: H410
EC Risk Classification Click here to view information omn the EU risk phrases -
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for halauxifen-methyl

Language Name
English halauxifen-methyl
French halauxifene-metyl
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish halauxifen-metyl
Hungarian -
Dutch -

Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk