Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

ethaboxam (Ref: LGC 30473)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Ethaboxam is a fungicide without EU regulatory approval for use. It has a low aqueous solubility and is volatile. Although it has a low mammalian toxicity it has a high potential to bioaccumulate. It is moderately toxic to birds, most aquatic species, honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for ethaboxam

Description: A systemic, thiazole fungicide used to control soil-borne pathogens

Example pests controlled: Blight; Damping-off; Root rot; Seed rot

Example applications: Vines; Potatoes; Corn; Soybeans; Cereals; vegetables including peas, lentils, chickpeas, beans

Efficacy & activity: -

Availability status: Obsolete

Introduction & key dates: 1999 Korea first registered

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule
Chemical formula C14H16N4OS2
Canonical SMILES CCC1=C(SC(=N1)NCC)C(=O)NC(C#N)C2=CC=CS2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) NQRFDNJEBWAUBL-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H16N4OS2/c1-3-9-12(21-14(18-9)16-4-2)13(19)17-10(8-15)11-6-5-7-20-11/h5-7,10H,3-4H2,1-2H3,(H,16,18)(H,17,19)/f/h16-17H
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Thiazole
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Systemic with protective and curative action. Inhibition of mitosis and cell division (Beta-tubulin assembly in mitosis).
CAS RN 162650-77-3
EC number -
CIPAC number 769
US EPA chemical code 090205
PubChem CID 11174640
Molecular mass (g mol-1) 320.43
PIN (Preferred Identification Name) rac-N-[(R)-cyano(thiophen-2-yl)methyl]-4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide
IUPAC name (RS)-N-(α-cyano-2-thenyl)-4-ethyl-2-(ethylamino)-1,3-thiazole-5-carboxamide
CAS name N-(cyano-2-thienylmethyl)-4-ethyl-2-(ethylamino)-5-thiazolecarboxamide
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 22
Examples of recorded resistance -
Physical state White to pale yellow crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • LG Life Sciences
  • Valent
  • Sumitomo
Example products using this active
  • LGC-30473 10% SC
  • Guardian
  • Intego Solo
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an aqueous solution or suspension concentrate. Often used as a seed dressing.


ENVIRONMENTAL FATE

for ethaboxam

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 12.4 F4 Low
Solubility - In organic solvents at 20oC (mg l-1) 0.39 E4 - n-Heptane -
140 E4 - Xylene -
11000 E4 - Ethyl acetate -
40000 E4 - Acetone -
Melting point (oC) 185 F4 - Decomposes -
Boiling point (oC) Decomposes before boiling F4 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable F4 -
Octanol-water partition coefficient at pH 7, 20oC P 7.76 X 1002 Calculated -
Log P 2.89 F4 Moderate
Bulk density (g ml-1)/Specific gravity 1.28 F4 -
Dissociation constant (pKa) at 25oC 3.6 F4 -
Note: Weak acid
Vapour pressure at 20oC (mPa) 8.10 X 10-02 F4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) - - -
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.43 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.95 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 17 R4 Non-persistent
DT50 (lab at 20oC) 17 R4 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note: -
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - Q2 Slightly mobile
Koc 693
Notes and range Estimated
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
N-[(Z)-amino(2-thienyl)methylidene]-4-ethyl-2-(ethylamino)-l,3-thiazole-5-carboxamide AMETC Soil - -
4-ethyl -2-(ethylamino)-l,3-thiazole-5-carboxamide ETTC Soil - -
4-ethyl-2-(ethylamino)-N-(2-thienylcarbonyl)-l,3-thiazole-5-carboxamide ETC Soil - -
4-ethyl-2-(ethylamino)-l,3-thiazole-5-carboxylic acid ETCA Soil - -


ECOTOXICOLOGY

for ethaboxam

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk Q3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 4.2 L2 Rat, 2 year High
(ppm diet) 100 -
Birds - Acute LD50 (mg kg-1) 2000 L3 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.102 L3 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.365 L3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.009 L3 Raphidocelis subcapitata High
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees (Apis spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) 51 L3 Moderate
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Unknown mode acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Bumblebees (Bombus spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
-
Mason bees (Osmia spp.) Contact acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Oral acute LD50 (worst case from 24 , 48 and 72 hour values - μg bee-1) - - -
Other pollinators (1) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Other pollinators (2) Acute LD50 (worst case from 24 , 48 and 72 hour values - μg insect-1) - - -
Mode of exposure -
Earthworms - Acute 14 day LC50 (mg kg-1) 1000 L3 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for ethaboxam

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 E4 Rat -
Mammals - Inhalation LC50 (mg l-1) 4.89 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Genotoxic Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

A0; B0; C0; D0; E0

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

-

-

General human health issues May damage male reproduction system
USEPA - some evidence to suggest possible human carcinogen
Key: Genotoxicity
A: Chromosome aberration (EFSA database)
B: DNA damage/repair (EFSA database)
C: Gene mutation (EFSA database)
D: Genome mutation (EFSA database)
E: Unspecified genotoxicity type (miscellaneous data source)
0: No data
1: Positive
2: Mixed/ambiguous results
3: Negative
Key: Other
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Not classified: Obsolete
EC Safety Classification Click here to view information omn the EU safety phrases Not classified: Obsolete
WHO Classification NL/O - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for ethaboxam

Language Name
English ethaboxam
French ethaboxam
German Ethaboxam
Danish ethaboxam
Italian ethaboxam
Spanish etaboxam
Greek -
Slovenian etaboksam
Polish etaboksam
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 28 June 2019
Contact: aeru@herts.ac.uk